<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0187-893X</journal-id>
<journal-title><![CDATA[Educación química]]></journal-title>
<abbrev-journal-title><![CDATA[Educ. quím]]></abbrev-journal-title>
<issn>0187-893X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Química]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0187-893X2023000200017</article-id>
<article-id pub-id-type="doi">10.22201/fq.18708404e.2023.2.83233</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Inteligencia artificial en el diseño de fármacos: hacia la inteligencia aumentada]]></article-title>
<article-title xml:lang="en"><![CDATA[Artificial intelligence in drug design: towards augmented intelligence]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Saldivar-González]]></surname>
<given-names><![CDATA[Fernanda I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-de Gortari]]></surname>
<given-names><![CDATA[Eli]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medina-Franco]]></surname>
<given-names><![CDATA[José L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Química Departamento de Farmacia]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Laboratorio Internacional Ibérico de Nanotecnología  ]]></institution>
<addr-line><![CDATA[Braga ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Química Departamento de Farmacia]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>34</volume>
<numero>2</numero>
<fpage>17</fpage>
<lpage>25</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0187-893X2023000200017&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0187-893X2023000200017&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0187-893X2023000200017&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El desarrollo e investigación de fármacos es un proceso complejo que a menudo se percibe más como un arte que como una ciencia. Las muchas incógnitas de las enfermedades humanas, su complejidad, y el gran tamaño del espacio químico para encontrar fármacos potenciales, hacen que la toma de decisiones en Química Farmacéutica sea excepcionalmente exigente. Por tal motivo, durante décadas y especialmente en años recientes, se han integrado al proceso de diseño de fármacos modelos computacionales, y en particular, modelos de inteligencia artificial (IA) en combinación con su uso racional (inteligencia e intuición humana basada en la experiencia). Aquí se proporciona una descripción general y crítica de ejemplos recientes de aplicaciones de IA en el diseño y desarrollo de fármacos. Se hace una discusión de los conceptos y enfoques computacionales involucrados, y se analizan las posibilidades y limitaciones del diseño de fármacos utilizando IA en conjunto con su uso racional (o &#8220;el razonamiento humano&#8221;): inteligencia aumentada.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Drug development and research is a complex process that is often perceived as more of an art than a science. The many unknowns of human diseases, their complexity, the patient-to-patient response, and the huge size of the chemical space for finding potential drugs make decision-making in Medicinal Chemistry exceptionally demanding. For this reason, for decades and especially in recent years, computational models, and in particular artificial intelligence (AI) models in combination with their rational use (human intelligence and intuition based on experience), have been integrated into the drug design process. An overview and critique of recent examples of AI applications in drug design and development are provided here. A discussion of the concepts and computational approaches involved is given, and the possibilities and limitations of drug design using AI coupled with human reasoning are analyzed: augmented intelligence.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Química Farmacéutica]]></kwd>
<kwd lng="es"><![CDATA[diseño de fármacos asistido por computadora]]></kwd>
<kwd lng="es"><![CDATA[inteligencia artificial]]></kwd>
<kwd lng="es"><![CDATA[inteligencia aumentada]]></kwd>
<kwd lng="es"><![CDATA[medicinal personalizada]]></kwd>
<kwd lng="en"><![CDATA[Medicinal Chemistry]]></kwd>
<kwd lng="en"><![CDATA[Computer-Aided Drug Design]]></kwd>
<kwd lng="en"><![CDATA[artificial intelligence]]></kwd>
<kwd lng="en"><![CDATA[augmented intelligence]]></kwd>
<kwd lng="en"><![CDATA[precision medicine]]></kwd>
</kwd-group>
</article-meta>
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