<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0187-893X</journal-id>
<journal-title><![CDATA[Educación química]]></journal-title>
<abbrev-journal-title><![CDATA[Educ. quím]]></abbrev-journal-title>
<issn>0187-893X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Química]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0187-893X2023000100060</article-id>
<article-id pub-id-type="doi">10.22201/fq.18708404e.2023.1.84649</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Versátil como ninguna, la química clic y su trascendencia en áreas diversas: de la ciencia de materiales a la investigación farmacéutica]]></article-title>
<article-title xml:lang="en"><![CDATA[Versatile as no other, click chemistry and its relevance in multiple areas: From materials science to pharmaceutical research]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guadarrama]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Méndez]]></surname>
<given-names><![CDATA[Luis José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cabrera-Quiñones]]></surname>
<given-names><![CDATA[Neyra Citlali]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz-Hernández]]></surname>
<given-names><![CDATA[Carlos Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Instituto de Investigaciones en Materiales ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>34</volume>
<numero>1</numero>
<fpage>60</fpage>
<lpage>69</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0187-893X2023000100060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0187-893X2023000100060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0187-893X2023000100060&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen En el año 2022 se otorgó el premio Nobel de química a Carolyn R. Bertozzi, Morten Meldal y K. Barry Sharpless por sus aportaciones en el desarrollo de la química clic y la química bioortogonal. La trascendencia de este tipo de reacciones radica en que, por su sencillez, selectividad, eficiencia y tolerancia a diferentes medios, incluido el acuoso, ha impactado no sólo en la química sintética de moléculas complejas y materiales, sino también en el área farmacéutica ,ya que, aplicando este tipo de reacciones es posible formar conjugados con biomoléculas como proteínas, abriendo la puerta a la exploración y comprensión de diversos procesos biológicos en los organismos vivos para acceder así a terapias dirigidas más eficientes. En el Instituto de Investigaciones en Materiales de la UNAM hemos aplicado esta reacción de manera exitosa para modificar directamente algunas moléculas bioactivas como la curcumina (antioxidante natural), mejorando sus propiedades fisicoquímicas como solubilidad y estabilidad química. Asimismo, aplicando reacciones clic se sintetizaron derivados de &#946;-ciclodextrina como nuevos acarreadores de fármacos, incorporando sustituyentes altamente ramificados llamados dendrones que confieren un adecuado balance hidrofílico/hidrofóbico. Estas modificaciones nos permitieron optimizar su paso a través de las membranas celulares por difusión, y su capacidad para encapsular fármacos hidrofóbicos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract In 2022, the Nobel Prize in Chemistry was awarded to Carolyn R. Bertozzi, Morten Meldal, and K. Barry Sharpless for their contributions to the development of click chemistry and bioorthogonal chemistry. The significance of this type of reaction lies in the fact that, due to its simplicity, selectivity, efficiency, and tolerance to different media, including aqueous, it has impacted not only on the synthetic chemistry of complex molecules and materials, but also in the pharmaceutical area, since the application of this type of reaction allows the formation of conjugates with biomolecules such as proteins, opening the door to the exploration and understanding of various biological processes in living organisms to access more efficient targeted therapies. At UNAM&#8217;s Materials Research Institute, we have successfully applied this reaction to directly modify some bioactive molecules like curcumin (a natural antioxidant), improving their physicochemical properties such as solubility and chemical stability. Also, applying click reactions were synthesized &#946;-cyclodextrin derivatives as new drug carriers, incorporating highly branched substituents called dendrons that confer an adequate hydrophilic/hydrophobic balance. These modifications allowed us to optimize their passage through cell membranes by diffusion and their ability to encapsulate hydrophobic drugs.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Química clic]]></kwd>
<kwd lng="es"><![CDATA[química bioortogonal]]></kwd>
<kwd lng="es"><![CDATA[acarreadores de fármacos]]></kwd>
<kwd lng="es"><![CDATA[conjugación]]></kwd>
<kwd lng="es"><![CDATA[dendronización]]></kwd>
<kwd lng="en"><![CDATA[Click chemistry]]></kwd>
<kwd lng="en"><![CDATA[bioorthogonal chemistry]]></kwd>
<kwd lng="en"><![CDATA[drug carriers]]></kwd>
<kwd lng="en"><![CDATA[conjugation]]></kwd>
<kwd lng="en"><![CDATA[dendronization]]></kwd>
</kwd-group>
</article-meta>
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