<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0187-893X</journal-id>
<journal-title><![CDATA[Educación química]]></journal-title>
<abbrev-journal-title><![CDATA[Educ. quím]]></abbrev-journal-title>
<issn>0187-893X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Química]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0187-893X2021000300003</article-id>
<article-id pub-id-type="doi">10.22201/fq.18708404e.2021.3.79714</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[El sistema CRISPR/Cas, crónica de un premio Nobel anunciado]]></article-title>
<article-title xml:lang="en"><![CDATA[The CRISPR / Cas&#8217;s system, chronicle of an announced Nobel prize]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zurita]]></surname>
<given-names><![CDATA[Mario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Instituto de Biotecnología Departamento de Genética del Desarrollo y Fisiología Molecular]]></institution>
<addr-line><![CDATA[Cuernavaca Morelos]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>32</volume>
<numero>3</numero>
<fpage>3</fpage>
<lpage>13</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0187-893X2021000300003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0187-893X2021000300003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0187-893X2021000300003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Desde principios de la década pasada en la que se creó como herramienta para editar genomas el sistema CRISPR/Cas, la comunidad científica se dio cuenta de los alcances que podría tener esta poderosa metodología. Con el paso de los años ésta se ha hecho mucho más robusta y se han generado una serie de herramientas colaterales, en muchos casos adaptadas para cada organismo, de tal forma que su uso se está volviendo rutinario en cualquier laboratorio de Biología Molecular. Por lo tanto, el premio Nobel a Emmanuelle Charpentier y a Jennifer Doudna, que participaron de manera importante en el desarrollo de esta metodología, era esperado. En este artículo se describe cuáles fueron los descubrimientos clave que se dieron para poder usar este conocimiento en el desarrollo de la que es, probablemente, la herramienta molecular más importante desde el desarrollo de la Ingeniería Genética, y también, cómo es que funciona para editar genomas y algunas otras aplicaciones.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Since the beginning of the last decade, when the CRISPR / Cas system was created as a tool to edit genomes, the scientific community realized the importance of this powerful methodology. Over the years it has become much more robust and a series of collateral tools have been generated, in many cases adapted for each organism, in such a way that it is becoming routinely used in any Molecular Biology laboratory. Therefore, the Nobel Prize to Emmanuelle Charpentier and Jennifer Doudna, who participated in an important way in the development of this methodology was expected. This article describes the key discoveries that were made in order to use this knowledge in the development of what is probably the most important molecular tool since the development of Genetic Engineering and also how it works to edit genomes as well as some other applications.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Sistema CRISPR/Cas]]></kwd>
<kwd lng="es"><![CDATA[crónica]]></kwd>
<kwd lng="es"><![CDATA[Nobel]]></kwd>
<kwd lng="es"><![CDATA[herramienta molecular]]></kwd>
<kwd lng="es"><![CDATA[Ingeniería Genética]]></kwd>
<kwd lng="en"><![CDATA[CRISPR / Cas&#8217;s system]]></kwd>
<kwd lng="en"><![CDATA[chronicle]]></kwd>
<kwd lng="en"><![CDATA[Nobel]]></kwd>
<kwd lng="en"><![CDATA[molecular tool]]></kwd>
<kwd lng="en"><![CDATA[Genetic engineering]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Anzalone]]></surname>
<given-names><![CDATA[A.V.]]></given-names>
</name>
<name>
<surname><![CDATA[Randolph]]></surname>
<given-names><![CDATA[P.B.]]></given-names>
</name>
<name>
<surname><![CDATA[Davis]]></surname>
<given-names><![CDATA[J.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[A.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Koblan]]></surname>
<given-names><![CDATA[L.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Levy]]></surname>
<given-names><![CDATA[J.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[P.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Wilson]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Newby]]></surname>
<given-names><![CDATA[G.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Raguram]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[D.R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Search-and-replace genome editing without double-strand breaks or donor DNA]]></article-title>
<source><![CDATA[Nature]]></source>
<year>2019</year>
<volume>576</volume>
<numero>7785</numero>
<issue>7785</issue>
<page-range>149-57</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bolotin]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Quinquis]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Sorokin]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ehrlich]]></surname>
<given-names><![CDATA[S.D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin]]></article-title>
<source><![CDATA[Microbiology]]></source>
<year>2005</year>
<volume>151</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>2551-61</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brouns]]></surname>
<given-names><![CDATA[S.J]]></given-names>
</name>
<name>
<surname><![CDATA[Jore]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Lundgren]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Westra]]></surname>
<given-names><![CDATA[E.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Slijkhuis]]></surname>
<given-names><![CDATA[R.J.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Snijders]]></surname>
<given-names><![CDATA[A.P.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Dickman]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Makarova]]></surname>
<given-names><![CDATA[K.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Koonin]]></surname>
<given-names><![CDATA[E.V.]]></given-names>
</name>
<name>
<surname><![CDATA[van der Oost]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Small CRISPR RNAs guide antiviral defense in prokaryotes]]></article-title>
<source><![CDATA[Science]]></source>
<year>2008</year>
<volume>321</volume>
<numero>5891</numero>
<issue>5891</issue>
<page-range>960-4</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cong]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Ran]]></surname>
<given-names><![CDATA[F.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Cox]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Barretto]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Habib]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Hsu]]></surname>
<given-names><![CDATA[P.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Jiang]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Marraffini]]></surname>
<given-names><![CDATA[L.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Multiplex genome engineering using CRISPR/Cas&#8217;s systems]]></article-title>
<source><![CDATA[Science]]></source>
<year>2013</year>
<volume>339</volume>
<numero>6121</numero>
<issue>6121</issue>
<page-range>819-23</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cox]]></surname>
<given-names><![CDATA[D. B. T.]]></given-names>
</name>
<name>
<surname><![CDATA[Gootenberg]]></surname>
<given-names><![CDATA[J.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Abudayyeh]]></surname>
<given-names><![CDATA[O.O.]]></given-names>
</name>
<name>
<surname><![CDATA[Franklin]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Kellner]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[RNA editing with CRISPR-Cas13]]></article-title>
<source><![CDATA[Science]]></source>
<year>2017</year>
<volume>358</volume>
<numero>6299</numero>
<issue>6299</issue>
<page-range>1019-27</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Deltcheva]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Chylinski]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[C.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Gonzales]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Chao]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Pirzada]]></surname>
<given-names><![CDATA[Z.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Eckert]]></surname>
<given-names><![CDATA[M.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Vogel]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Charpentier]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III]]></article-title>
<source><![CDATA[Nature]]></source>
<year>2011</year>
<volume>471</volume>
<numero>7340</numero>
<issue>7340</issue>
<page-range>602-7</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dominguez]]></surname>
<given-names><![CDATA[A.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Lim]]></surname>
<given-names><![CDATA[W.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Qi]]></surname>
<given-names><![CDATA[L.S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation]]></article-title>
<source><![CDATA[Nat. Rev. Mol. Cell Biol.]]></source>
<year>2016</year>
<volume>17</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>5-15</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Garneau]]></surname>
<given-names><![CDATA[J.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Dupuis]]></surname>
<given-names><![CDATA[M.È.]]></given-names>
</name>
<name>
<surname><![CDATA[Villion]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Romero]]></surname>
<given-names><![CDATA[D.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Barrangou]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Boyaval]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Fremaux]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Horvath]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Magadán]]></surname>
<given-names><![CDATA[A.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Moineau]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA]]></article-title>
<source><![CDATA[Nature]]></source>
<year>2010</year>
<volume>468</volume>
<numero>7320</numero>
<issue>7320</issue>
<page-range>67-71</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gasiunas]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Barrangou]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Horvath]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Siksnys]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria]]></article-title>
<source><![CDATA[Proc. Natl. Acad.y Sci.]]></source>
<year>2012</year>
<volume>109</volume>
<numero>39</numero>
<issue>39</issue>
<page-range>2579-86</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gootenberg]]></surname>
<given-names><![CDATA[J.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Abudayyeh]]></surname>
<given-names><![CDATA[O.O.]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[J.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Essletzbichler]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Dy]]></surname>
<given-names><![CDATA[A.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nucleic Acid Detection with CRISPR-Cas13a/C2c2]]></article-title>
<source><![CDATA[Science]]></source>
<year>2017</year>
<volume>356</volume>
<numero>6336</numero>
<issue>6336</issue>
<page-range>438-42</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Grünewald]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Lareau]]></surname>
<given-names><![CDATA[C.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Garcia]]></surname>
<given-names><![CDATA[S.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Iyer]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[B.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Langner]]></surname>
<given-names><![CDATA[L.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Hsu]]></surname>
<given-names><![CDATA[J.Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Aryee]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Joung]]></surname>
<given-names><![CDATA[J.K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing]]></article-title>
<source><![CDATA[Nat Biotechnol.]]></source>
<year>2020</year>
<volume>38</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>861-4</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Haft]]></surname>
<given-names><![CDATA[D.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Selengut]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Mongodin]]></surname>
<given-names><![CDATA[E.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Nelson]]></surname>
<given-names><![CDATA[K. E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes]]></article-title>
<source><![CDATA[PLoS Comput Biol.]]></source>
<year>2005</year>
<volume>1</volume>
<numero>6</numero>
<issue>6</issue>
</nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jinek]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Chylinski]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Fonfara]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Hauer]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Doudna]]></surname>
<given-names><![CDATA[J.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Charpentier]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity]]></article-title>
<source><![CDATA[Science]]></source>
<year>2012</year>
<volume>337</volume>
<numero>6096</numero>
<issue>6096</issue>
<page-range>816-21</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mali]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Esvelt]]></surname>
<given-names><![CDATA[K.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Aach]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Guell]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[DiCarlo]]></surname>
<given-names><![CDATA[J.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Norville]]></surname>
<given-names><![CDATA[J.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Church]]></surname>
<given-names><![CDATA[G.M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[RNA-guided human genome engineering via Cas9]]></article-title>
<source><![CDATA[Science]]></source>
<year>2013</year>
<volume>339</volume>
<numero>6121</numero>
<issue>6121</issue>
<page-range>823-6</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marraffini]]></surname>
<given-names><![CDATA[L.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Sontheimer]]></surname>
<given-names><![CDATA[E.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA]]></article-title>
<source><![CDATA[Science]]></source>
<year>2008</year>
<volume>322</volume>
<numero>5909</numero>
<issue>5909</issue>
<page-range>1843-5</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mitsunobu]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Teramoto]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Nishida]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Kondo]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Beyond Native Cas9: Manipulating Genomic Information and Function]]></article-title>
<source><![CDATA[Trends Biotechnol]]></source>
<year>2017</year>
<volume>35</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>983-96</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mojica]]></surname>
<given-names><![CDATA[F.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Díez-Villaseñor]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Soria]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Juez]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria]]></article-title>
<source><![CDATA[Mol. Microbio.]]></source>
<year>2000</year>
<volume>36</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>244-6</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mojica]]></surname>
<given-names><![CDATA[F.J.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Dez-Villaseñor]]></surname>
<given-names><![CDATA[C.S.]]></given-names>
</name>
<name>
<surname><![CDATA[García-Martínez]]></surname>
<given-names><![CDATA[J.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Soria]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements]]></article-title>
<source><![CDATA[J. Mol. Evol.]]></source>
<year>2005</year>
<volume>60</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>174-82</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sapranauskas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Gasiunas]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Fremaux]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Barrangou]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Horvath]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Siksnys]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Streptococcus thermophilus CRISPR/Cas&#8217;s system provides immunity in Escherichia coli]]></article-title>
<source><![CDATA[Nucl. Acids Res.]]></source>
<year>2011</year>
<volume>39</volume>
<numero>21</numero>
<issue>21</issue>
<page-range>9275-82</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
