<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0187-893X</journal-id>
<journal-title><![CDATA[Educación química]]></journal-title>
<abbrev-journal-title><![CDATA[Educ. quím]]></abbrev-journal-title>
<issn>0187-893X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Química]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0187-893X2019000200054</article-id>
<article-id pub-id-type="doi">10.22201/fq.18708404e.2019.2.67393</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Avaliação e otimização das condições de obtenção do ácido acetilsalicílico para fins didáticos]]></article-title>
<article-title xml:lang="en"><![CDATA[Evaluation and optimization of the conditions for obtaining acetilsalicylic acid for didactic purposes]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Luz]]></surname>
<given-names><![CDATA[Leslie Tauany Schneider da]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gomes]]></surname>
<given-names><![CDATA[Sandra Inês Adams Angnes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sandri]]></surname>
<given-names><![CDATA[Marilei Casturina Mendes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mello]]></surname>
<given-names><![CDATA[Flávia de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bolzan]]></surname>
<given-names><![CDATA[Juliana Aparecida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Federal do Paraná  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Federal do Paraná  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade Estadual de Ponta Grossa  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade Regional de Blumenau  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto Federal do Paraná  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<volume>30</volume>
<numero>2</numero>
<fpage>54</fpage>
<lpage>69</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0187-893X2019000200054&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0187-893X2019000200054&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0187-893X2019000200054&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A síntese do ácido acetilsalicílico (AAS) é muito empregada em aulas experimentais de Química para explorar o ensino de reações nucleofílicas e o processo de purificação por recristalização. Considerando a diversidade de protocolos disponíveis na literatura, com divergências nas condições experimentais, este trabalho teve como objetivo otimizar as condições de tempo e temperatura da síntese do AAS e, concomitante, melhorar a verdura química do processo visando maior eficiência mássica e energética, de acordo com os princípios 1, 2 e 6 da Química Verde (QV). Para isso, propôs-se a síntese de AAS a temperaturas de 40 °C, 50 °C, 60 °C, 70 °C, 80 e 90 °C durante 10, 20, 30 e 40 minutos de reação. Os resultados apontam que o AAS obtido em 20 minutos a 80°C apresentou os melhores resultados: um bom rendimento, 77,70 ± 0,01 %, com ponto de fusão 133 °C-134 °C, com Eficiência de Massa 24 % e Fator E 3,10; as melhores métricas de energia, Throughput 0,101 g min-1, Intensidade de Tempo 9,869 min g-1, Intensidade de Energia 0,073 Kw h g-1 e o menor consumo de energia, 0,1485 KWh, um ganho de eficiência energética de aproximadamente 200 %, contribuindo principalmente com melhorias no P6 da QV.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The synthesis of acetylsalicylic acid (ASA) is widely used in experimental chemistry classes for the teaching of nucleophilic reactions and the process of purification by recrystallization. Considering the diversity of protocols available in the literature, with divergences in the experimental conditions, this work had as objective to optimize the time and temperature conditions of the ASA synthesis and, at the same time, to improve the chemical greenery of the process aiming at greater mass and energetic efficiency, according to with principles 1, 2 and 6 of Green Chemistry (GC). For this, the synthesis of ASA was proposed at temperatures of 40 ° C, 50 °C, 60 °C, 70 °C, 80 and 90 °C for 10, 20, 30 and 40 minutes of reaction. The results indicate that the ASA obtained in 20 minutes at 80 °C presented the best results: a good yield, 77.70 ± 0.01%, with melting point 133 °C -134 °C, with Experimental Mass Efficiency 24% and Environmental Factor E 3,10; the best energy metrics, Throughput 0,101 g min-1, Time Intensity 9.869 min g-1, Energy Intensity 0.073 Kw h g-1 and the lowest power consumption, 0.1485 KWh, an efficiency gain approximately 200 %, contributing mainly to improvements in P6 of GC.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Ácido acetilsalicílico]]></kwd>
<kwd lng="pt"><![CDATA[Eficiência Energética]]></kwd>
<kwd lng="pt"><![CDATA[Métricas de Massa, Ensino]]></kwd>
<kwd lng="en"><![CDATA[Acetylsalicylic acid]]></kwd>
<kwd lng="en"><![CDATA[Energy Efficiency]]></kwd>
<kwd lng="en"><![CDATA[Mass Metrics, Teaching]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Andraos]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Dicks]]></surname>
<given-names><![CDATA[A.P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Green chemistry teaching in higher education: a review of effective practices]]></article-title>
<source><![CDATA[Chemistry Education Research and Practice]]></source>
<year>2012</year>
<volume>2</volume>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Anastas]]></surname>
<given-names><![CDATA[P.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Warner]]></surname>
<given-names><![CDATA[J.C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Green Chemistry: theory and Pratice]]></source>
<year>1998</year>
<publisher-loc><![CDATA[New York ]]></publisher-loc>
<publisher-name><![CDATA[Oxford University Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="">
<collab>Anvisa</collab>
<source><![CDATA[Agencia Nacional de Vigilância Sanitária, Farmacopeia Brasileira]]></source>
<year>2010</year>
<edition>2</edition>
</nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carron]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
</person-group>
<source><![CDATA[Física Eletrodinâmica, 2016]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gaspar]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Compreendendo a Física. Eletromagnetismo e Física Moderna]]></source>
<year>2017</year>
<volume>3</volume>
<publisher-name><![CDATA[Editora ática]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
<name>
<surname><![CDATA[Cesteros]]></surname>
<given-names><![CDATA[Y .]]></given-names>
</name>
<name>
<surname><![CDATA[Salagre]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estabelecendo o papel da acidez e porosidade de Brønsted para a eterificação catalítica de glicerol com tert-butanol, modificando zeólitas]]></article-title>
<source><![CDATA[Catálise Aplicada A: Geral]]></source>
<year>2013</year>
<numero>450</numero>
<issue>450</issue>
<page-range>178-88</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lenardão]]></surname>
<given-names><![CDATA[E.J]]></given-names>
</name>
<name>
<surname><![CDATA[Freitag]]></surname>
<given-names><![CDATA[R.A]]></given-names>
</name>
<name>
<surname><![CDATA[Dabdoub]]></surname>
<given-names><![CDATA[M.J]]></given-names>
</name>
<name>
<surname><![CDATA[Bastista]]></surname>
<given-names><![CDATA[A.C.F]]></given-names>
</name>
<name>
<surname><![CDATA[Silveira]]></surname>
<given-names><![CDATA[C.C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Green Chemistry&#8221;- Os 12 Princípios da Química Verde e sua inserção nas atividades de ensino e pesquisa]]></article-title>
<source><![CDATA[Química Nova]]></source>
<year>2003</year>
<volume>26</volume>
<page-range>123-9</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Luengo]]></surname>
<given-names><![CDATA[M. B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A historical revision of the main immunological events and pharmacology in the search of the understanding and treatment of inflammatory diseases]]></article-title>
<source><![CDATA[Revista Eletrônica de Farmácia. São Paulo]]></source>
<year>2005</year>
<volume>2</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>64-72</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Machado]]></surname>
<given-names><![CDATA[A. A. S. C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bateria de métricas para avaliação de verdura material de reações de síntese]]></article-title>
<source><![CDATA[Química Nova]]></source>
<year>2014</year>
<volume>37</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1094-109</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Machado]]></surname>
<given-names><![CDATA[A. A. S. C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Introdução às Métricas da Química Verde: uma visão sistêmica]]></source>
<year>2014</year>
<publisher-loc><![CDATA[Florianópolis, BR ]]></publisher-loc>
<publisher-name><![CDATA[Editora UFSC]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Massabni]]></surname>
<given-names><![CDATA[A. C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Aspirina. Química viva]]></source>
<year>2006</year>
<publisher-name><![CDATA[Instituto de Química]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Medeiros]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Estudo das Reações entre Hidroxilamina e Aspirinas substituídas]]></source>
<year>2006</year>
<publisher-loc><![CDATA[Florianópolis ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mendes]]></surname>
<given-names><![CDATA[A. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Peruch]]></surname>
<given-names><![CDATA[M. G. B.]]></given-names>
</name>
<name>
<surname><![CDATA[Fritzen]]></surname>
<given-names><![CDATA[M. F.]]></given-names>
</name>
</person-group>
<source><![CDATA[Síntese e purificação do ácido acetilsalicílico através da recristalização utilizando diferentes tipos de solventes]]></source>
<year>2012</year>
</nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Menegatti]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Fraga]]></surname>
<given-names><![CDATA[C. A. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Barreiro]]></surname>
<given-names><![CDATA[E. K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A Importância da Síntese de Fármacos]]></article-title>
<source><![CDATA[Cadernos Temáticos de Química Nova na Escola]]></source>
<year>2011</year>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Neto]]></surname>
<given-names><![CDATA[A. P. S]]></given-names>
</name>
<name>
<surname><![CDATA[Filho]]></surname>
<given-names><![CDATA[J. G. R]]></given-names>
</name>
<name>
<surname><![CDATA[Alves]]></surname>
<given-names><![CDATA[A. J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Síntese do Ácido Acetilsalicílico (AAS)]]></source>
<year>2012</year>
<publisher-name><![CDATA[Escola Técnica Estadual Professor Agamêmnon Magalhães]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ortiz]]></surname>
<given-names><![CDATA[M. A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Monografia de Conclusão de Curso]]></source>
<year>2007</year>
<publisher-loc><![CDATA[Brasil ]]></publisher-loc>
<publisher-name><![CDATA[Universidade Federal De Pelotas]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pavia]]></surname>
<given-names><![CDATA[D.L]]></given-names>
</name>
<name>
<surname><![CDATA[Lapman]]></surname>
<given-names><![CDATA[G.M]]></given-names>
</name>
<name>
<surname><![CDATA[Kriz]]></surname>
<given-names><![CDATA[G. Z.]]></given-names>
</name>
</person-group>
<source><![CDATA[Química orgânica experimental]]></source>
<year>2009</year>
<edition>Segunda</edition>
<page-range>59-67</page-range><publisher-loc><![CDATA[Porto Alegre ]]></publisher-loc>
<publisher-name><![CDATA[Bookmam]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pires]]></surname>
<given-names><![CDATA[T. C. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[M.G. T. C]]></given-names>
</name>
<name>
<surname><![CDATA[Machado]]></surname>
<given-names><![CDATA[A. A. S. C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Extração do R-(+)-limoneno a partir das cascas de laranja: avaliação e otimização da verdura dos processos de extração tradicionais]]></article-title>
<source><![CDATA[Portugal. Quimica Nova]]></source>
<year>2018</year>
<volume>41</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>355-65</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pinto]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<source><![CDATA[Síntese do Ácido Acetilsalicílico]]></source>
<year>2004</year>
<publisher-name><![CDATA[Escola Secundária do Padre António Martins Oliveira de Lagoa]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="">
<source><![CDATA[Química Orgânica I. Pontos de fusão- Trabalho prático nº1, 1º Ciclo enologia]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ramos]]></surname>
<given-names><![CDATA[M. A. F. A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Química Verde - Potencialidades e dificuldades da sua introdução no ensino básico e secundário. Mestrado em química para o ensino]]></source>
<year>2009</year>
</nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="confpro">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Santiago]]></surname>
<given-names><![CDATA[J. C. C]]></given-names>
</name>
<name>
<surname><![CDATA[Gomes]]></surname>
<given-names><![CDATA[P.W.P]]></given-names>
</name>
<name>
<surname><![CDATA[Muribeca]]></surname>
<given-names><![CDATA[A.J.B]]></given-names>
</name>
<name>
<surname><![CDATA[Azevedo]]></surname>
<given-names><![CDATA[W.H.C]]></given-names>
</name>
</person-group>
<source><![CDATA[Síntese e determinação do Ponto de Fusão de Aspirina]]></source>
<year>2017</year>
<conf-name><![CDATA[ ° congresso Brasileiro de Química]]></conf-name>
<conf-loc>Gramado, RS </conf-loc>
</nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[A.C.Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Marins]]></surname>
<given-names><![CDATA[F.A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Síntese e Caracterização do Ácido Acetilsalicílico]]></source>
<year>2010</year>
</nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Recristalização e Ponto de fusão]]></source>
<year>2012</year>
<publisher-name><![CDATA[LQO]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vogel]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Química Analítica Quantitativa]]></source>
<year>1978</year>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
