<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0187-5337</journal-id>
<journal-title><![CDATA[Perinatología y reproducción humana]]></journal-title>
<abbrev-journal-title><![CDATA[Perinatol. Reprod. Hum.]]></abbrev-journal-title>
<issn>0187-5337</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Perinatología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0187-53372022000100025</article-id>
<article-id pub-id-type="doi">10.24875/per.20000024</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Exencefalia: diagnóstico prenatal y reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Exencephaly: prenatal diagnosis and case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ostia-Garza]]></surname>
<given-names><![CDATA[Patricia J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Luna-Ríos]]></surname>
<given-names><![CDATA[Erika]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Plaza-Benhumea]]></surname>
<given-names><![CDATA[Lautaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Materno Perinatal Mónica Pretelini Sáenz Servicio de Neonatología ]]></institution>
<addr-line><![CDATA[ Estado de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Materno Perinatal Mónica Pretelini Sáenz Servicio de Genética ]]></institution>
<addr-line><![CDATA[ Estado de México]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>36</volume>
<numero>1</numero>
<fpage>25</fpage>
<lpage>29</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0187-53372022000100025&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0187-53372022000100025&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0187-53372022000100025&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La exencefalia es una malformación fetal, donde restos de materia encefálica se encuentran afuera de la bóveda craneal. Las malformaciones congénitas constituyen un problema de salud en nuestro país, la tasa de malformaciones es del orden del 2 al 6% de los recién nacidos. Las malformaciones del sistema nervioso central ocupan el segundo lugar en población de México. Al igual que la mayoría de las malformaciones congénitas, las del sistema nervioso central son un grupo de afecciones de etiología multifactorial, producto de una interacción de factores genéticos, infecciosos, ambientales, raciales, agentes físicos y químicos, y la deficiencia o alteración en el metabolismo del ácido fólico. Se presenta un caso de exencefalia, así como una revisión de la embriología de esta entidad, con énfasis en la importancia del uso del ácido fólico en la etapa de embriogénesis del sistema nervioso central, así como la importancia del abordaje prenatal.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Exencephaly is a type of cephalic disorder, where the brain is located outside of the skull. Congenital malformations constitute a public health problem in Mexico, affecting approximately 2-6% of newborns. Central nervous system malformations are the second most frequent malformations in the population of Mexico. As with most congenital malformations, the etiology of central nervous system anomalies is multifactorial, resulting from interactions among genetic, infectious, environmental, racial, physical and chemical factors, and deficiency or alteration of folic acid metabolism. We also review the embryology of this entity, with emphasis of the importance of folic acid intake at the stage of central nervous system embryogenesis, and also the importance of the prenatal care.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Exencefalia]]></kwd>
<kwd lng="es"><![CDATA[Defectos del tubo neural]]></kwd>
<kwd lng="es"><![CDATA[Abordaje prenatal]]></kwd>
<kwd lng="es"><![CDATA[Cuidados paliativos]]></kwd>
<kwd lng="en"><![CDATA[Exencephaly]]></kwd>
<kwd lng="en"><![CDATA[Central nervous system malformations]]></kwd>
<kwd lng="en"><![CDATA[Prenatal care]]></kwd>
<kwd lng="en"><![CDATA[Paliative care]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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