<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662019000200198</article-id>
<article-id pub-id-type="doi">10.24245/mim.v35i2.2219</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Resultados de un programa de detección temprana de nefropatía diabética]]></article-title>
<article-title xml:lang="en"><![CDATA[Results of a program of early detection of diabetic nephropathy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Polanco-Flores]]></surname>
<given-names><![CDATA[Nasser Abdel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Castellanos]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Guillermo Álvarez Macías  ]]></institution>
<addr-line><![CDATA[ Hidalgo]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Cardiología Ignacio Chávez  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>35</volume>
<numero>2</numero>
<fpage>198</fpage>
<lpage>207</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662019000200198&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662019000200198&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662019000200198&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES:  La nefropatía diabética constituye la primera causa de enfermedad renal crónica y sustitución de la función renal en todo el mundo.  OBJETIVO:  Evaluar los factores de riesgo del inicio y progresión de la nefropatía diabética.  MATERIAL Y MÉTODO:  Estudio descriptivo, retrospectivo, transversal, mediante análisis de pruebas de función renal, como la depuración de creatinina y albuminuria de 24 horas, en el que se realizó la búsqueda intencionada de hallazgos anormales en pacientes atendidos de enero a diciembre de 2016 en el área de consulta externa de un hospital general de segundo nivel de atención. Los datos se analizaron usando el paquete estadístico SPSS versión 15 para Windows.  RESULTADOS:  Se incluyeron 56 pacientes, fue posible detectar nefropatía diabética en 61% de la población contra 30% mediante técnicas tradicionalmente utilizadas en la consulta general de pacientes diabéticos. Se encontró al tabaquismo activo [OR 3.500 (IC95%, 1.188-22.511)] y a la hiperglucemia persistente como los principales factores asociados con la aparición de nefropatía [OR 2.143 (IC95%, 1.145-4.009)], el nivel de control subóptimo prolongado constituyó el denominador común que los diferenció de la población sin nefropatía diabética (p = 0.002).  CONCLUSIONES:  El tabaquismo activo y la hiperglucemia persistente fueron los principales factores asociados con la aparición de nefropatía.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND:  Diabetic nephropathy is the first cause of chronic kidney disease and renal function replacement worldwide.  OBJECTIVE:  To evaluate the risk factors of initiation-progression of diabetic nephropathy.  MATERIAL AND METHOD:  A cross-sectional, retrospective, descriptive study, through analysis of renal function tests, such as the creatinine and albuminuria clearance of 24 hours, an intentional search of abnormal findings was carried out from January to December 2018 in the external consultation of a second level general hospital. The data was analyzed using the statistical package SPSS version 15 for Windows.  RESULTS:  There were included 56 patients. It was possible to detect diabetic nephropathy in 61% of the population against 30% by means of techniques traditionally used in the general consultation of diabetic patients. Active smoking [OR 3.500 (95%CI, 1188-22211)] and persistent hyperglycemia were found as the main factors associated with the development of nephropathy [OR 2.143 (95%CI, 1.145-4.009)], constituting the level of prolonged suboptimal control the common denominator that differentiates them from the population without diabetic nephropathy (p = 0.002).  CONCLUSIONS:  Active smoking and persistent hyperglycemia were found as the main factors associated with the development of nephropathy.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Nefropatía diabética]]></kwd>
<kwd lng="es"><![CDATA[diabetes mellitus tipo 2]]></kwd>
<kwd lng="es"><![CDATA[insuficiencia renal crónica]]></kwd>
<kwd lng="es"><![CDATA[albuminuria]]></kwd>
<kwd lng="en"><![CDATA[Diabetic nephropathy]]></kwd>
<kwd lng="en"><![CDATA[Diabetes mellitus, Type 2]]></kwd>
<kwd lng="en"><![CDATA[Renal insufficiency, Chronic]]></kwd>
<kwd lng="en"><![CDATA[Albuminuria]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Eckardt]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Coresh]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Devuyst]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Johnson]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Köttgen]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Levey]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evolving importance of kidney disease from subspecialty to global health burden]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2013</year>
<volume>382</volume>
<numero>9887</numero>
<issue>9887</issue>
<page-range>158-69</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="">
<source><![CDATA[nnual Data Report 2012 de Unites States Renal Data System]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="confpro">
<source><![CDATA[Registro de la Sociedad Española de Nefrología]]></source>
<year></year>
<conf-name><![CDATA[ XLVI Congreso Anual SEN]]></conf-name>
<conf-date>2016</conf-date>
<conf-loc>Oviedo </conf-loc>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Méndez-Durán]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Méndez-Bueno]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Tapia-Yáñez]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Muñoz-Montes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Aguilar-Sánchez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Epidemiología de la insuficiencia renal crónica en México]]></article-title>
<source><![CDATA[Dial Traspl]]></source>
<year>2010</year>
<volume>31</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>7-11</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wild]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Roglic]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Green]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sicree]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[King]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Global prevalence of diabetes estimates for the year 2000 and projections for 2030]]></article-title>
<source><![CDATA[Diabetes Care]]></source>
<year>2004</year>
<volume>27</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1047-53</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ruospo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Saglimbene]]></surname>
<given-names><![CDATA[VM]]></given-names>
</name>
<name>
<surname><![CDATA[Palmer]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
<name>
<surname><![CDATA[De Cosmo]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Pacilli]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Lamacchia]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Glucose targets for preventing diabetic kidney disease and its progression]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2017</year>
<volume>8</volume>
<numero>6</numero>
<issue>6</issue>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[MacIsaac]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Jerums]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Ekinci]]></surname>
<given-names><![CDATA[EI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of glycaemic management on diabetic kidney disease]]></article-title>
<source><![CDATA[World J Diabetes]]></source>
<year>2017</year>
<volume>8</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>172-86</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yokoyama]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Okudaira]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Otani]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Sato]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Miura]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Takaike]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Higher incidence of diabetic nephropathy in type 2 than in type 1 diabetes in early-onset diabetes in Japan]]></article-title>
<source><![CDATA[Kidney Int]]></source>
<year>2000</year>
<volume>58</volume>
<page-range>302-11</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hasslacher]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Ritz]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Wahl]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Michael]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Similar risks of nephropathy in patients with type I or type II diabetes mellitus]]></article-title>
<source><![CDATA[Nephrol Dial Transplant]]></source>
<year>1989</year>
<volume>4</volume>
<page-range>859-63</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tan]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Zwi]]></surname>
<given-names><![CDATA[LJ]]></given-names>
</name>
<name>
<surname><![CDATA[Collins]]></surname>
<given-names><![CDATA[JF]]></given-names>
</name>
<name>
<surname><![CDATA[Marshall]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
<name>
<surname><![CDATA[Cundy]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Presentation, pathology and prognosis of renal disease in type 2 diabetes]]></article-title>
<source><![CDATA[BMJ Open Diabetes Res Care]]></source>
<year>2017</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tziomalos]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Athyros]]></surname>
<given-names><![CDATA[VG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetic nephropathy new risk factors and improvement in diagnosis]]></article-title>
<source><![CDATA[Rev Diabet Stud]]></source>
<year>2015</year>
<volume>12</volume>
<numero>1-2</numero>
<issue>1-2</issue>
<page-range>110-8</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parving]]></surname>
<given-names><![CDATA[HH]]></given-names>
</name>
<name>
<surname><![CDATA[Mauer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Fioretto]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Rossing]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Ritz]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetic Nephropathy]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Taal]]></surname>
<given-names><![CDATA[MW]]></given-names>
</name>
<name>
<surname><![CDATA[Chertow]]></surname>
<given-names><![CDATA[GM]]></given-names>
</name>
<name>
<surname><![CDATA[Marsden]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
<name>
<surname><![CDATA[Skorecki]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[ASL]]></given-names>
</name>
<name>
<surname><![CDATA[Brenner]]></surname>
<given-names><![CDATA[BM.]]></given-names>
</name>
</person-group>
<source><![CDATA[Brenner &amp; Rector's The Kidney]]></source>
<year>2012</year>
<volume>35</volume>
<edition>9</edition>
<page-range>1411-37</page-range><publisher-loc><![CDATA[Philadelphia ]]></publisher-loc>
<publisher-name><![CDATA[Elsevier Saunders]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fioretto]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Mauer]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Bilous]]></surname>
<given-names><![CDATA[RW]]></given-names>
</name>
<name>
<surname><![CDATA[Goetz]]></surname>
<given-names><![CDATA[FC]]></given-names>
</name>
<name>
<surname><![CDATA[Sutherland]]></surname>
<given-names><![CDATA[DE]]></given-names>
</name>
<name>
<surname><![CDATA[Steffes]]></surname>
<given-names><![CDATA[MW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of pancreas transplantation of glomerular structure in insulin-dependent diabetic patients with their own kidneys]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>1993</year>
<volume>342</volume>
<page-range>1193-6</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fioretto]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Mauer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reversal of diabetic nephropathy lessons from pancreas transplantation]]></article-title>
<source><![CDATA[J Nephrol]]></source>
<year>2012</year>
<volume>25</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>13</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fioretto]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Barzon]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Mauer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Is diabetic nephropathy reversible]]></article-title>
<source><![CDATA[Diabetes Res Clin Pract]]></source>
<year>2014</year>
<volume>104</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>323-8</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<collab>American Diabetes Association</collab>
<article-title xml:lang=""><![CDATA[Standards of medical care in diabetes 2015]]></article-title>
<source><![CDATA[Diabetes Care]]></source>
<year>2015</year>
<volume>38</volume>
<numero>^sSuppl 1</numero>
<issue>^sSuppl 1</issue>
<supplement>Suppl 1</supplement>
<page-range>S1-S94</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="">
<collab>Asociación Latinoamericana de Diabetes</collab>
<source><![CDATA[Prevención, diagnóstico y tratamiento temprano de la nefropatía diabética. Recomendaciones de la Asociación Latinoamericana de Diabetes (ALAD) avalado por la Sociedad Latinoamericana de Nefrología e Hipertensión (SLANH). Consensos ALAD, 2016]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="book">
<source><![CDATA[Guía de práctica clínica prevención, diagnóstico y tratamiento de la enfermedad renal crónica temprana]]></source>
<year>2009</year>
<publisher-loc><![CDATA[México ]]></publisher-loc>
<publisher-name><![CDATA[Secretaría de Salud]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
