<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662018000600009</article-id>
<article-id pub-id-type="doi">10.24245/mim.v34i6.2116</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Abordaje diagnóstico de tumor primario desconocido: la fiebre de origen oscuro de las neoplasias]]></article-title>
<article-title xml:lang="en"><![CDATA[Diagnostic approach of unknown primary tumor: fever of obscure origin of neoplasms.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rebolledo-García]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Contreras]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Granados-Moreno]]></surname>
<given-names><![CDATA[Diana Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Dr. Nicolás San Juan  ]]></institution>
<addr-line><![CDATA[Toluca Estado de México]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,IMSS Unidad de Medicina Familiar núm. 250 ]]></institution>
<addr-line><![CDATA[Toluca Estado de México]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>34</volume>
<numero>6</numero>
<fpage>896</fpage>
<lpage>909</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662018000600009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662018000600009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662018000600009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El diagnóstico de un tumor primario desconocido suele ser difícil por su comportamiento clínico-patológico, su clínica emerge tardíamente de tal manera que la integración de un protocolo diagnóstico a partir de un síntoma o hallazgo clínico inespecífico condiciona el retraso de su abordaje. Las características propias de este tumor le confieren las herramientas mínimas necesarias para abandonar tempranamente su nicho de origen, diseminándose y alojándose distante al mismo, es decir, una metástasis temprana. El desarrollo de técnicas moleculares que sobrepasan la patología clásica ha sido una herramienta invaluable para su clasificación, teniendo la intención absoluta de separar los potencialmente sensibles a un tratamiento oncológico de los que no lo son. Sin rasgos distintivos que te permitan suponerlo, ante un clínico avezado la sospecha inicial de esta entidad es la mejor herramienta diagnóstica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: The diagnosis of an unknown primary tumor is usually difficult due to its clinical-pathological behavior; its clinical manifestation is delayed so that the integration of a diagnostic protocol from a symptom or nonspecific clinical finding determines the delay of its approach. The characteristics of this tumor give it the minimum necessary tools to leave its niche of origin early, disseminating and staying distant from it, that is, an early metastasis. The development of molecular techniques that surpass the classic pathology has been an invaluable tool for its classification, having an absolute intention to separate those potentially sensitive to oncological treatment from those that are not. Without distinctive features that allow supposing it, before a seasoned clinician the initial suspicion of this entity is the best diagnostic tool.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Tumor primario desconocido]]></kwd>
<kwd lng="en"><![CDATA[Unknown primary tumor]]></kwd>
</kwd-group>
</article-meta>
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