<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662018000400005</article-id>
<article-id pub-id-type="doi">10.24245/mim.v34i4.1898</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efecto de la administración de vitamina K en las complicaciones asociadas con enfermedad hepática crónica terminal]]></article-title>
<article-title xml:lang="en"><![CDATA[Effect of the administration of vitamin K on the complications associated with end stage liver disease.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez-Saucedo]]></surname>
<given-names><![CDATA[Roberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santoyo-Sánchez]]></surname>
<given-names><![CDATA[Adrián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Galván-Flores]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez-Espinoza]]></surname>
<given-names><![CDATA[Miguel Ángel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Durán-Guzmán]]></surname>
<given-names><![CDATA[Raymundo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salcedo-Roldán,]]></surname>
<given-names><![CDATA[Mario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramos-Peñafiel]]></surname>
<given-names><![CDATA[Christian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General de Cuautitlán  ]]></institution>
<addr-line><![CDATA[ Estado de México]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital General de México Dr. Eduardo Liceaga  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<volume>34</volume>
<numero>4</numero>
<fpage>551</fpage>
<lpage>556</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662018000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662018000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662018000400005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES La administración de vitamina K se restringe a situaciones, como antídoto de los antagonistas de vitamina K y enfermedad hemorrágica del recién nacido, pero debido a su papel en la hemostasia, su administración se ha extendido al tratamiento de otras enfermedades, como la enfermedad hepática crónica.  OBJETIVO Identificar la eficacia de adicionar vitamina K al tratamiento de los pacientes con insuficiencia hepática terminal con algún estado de descompensación.  MATERIAL Y MÉTODO  Estudio de casos y controles retrospectivo realizado en el periodo 2016-2017 en pacientes con enfermedad hepática crónica estadio Child-Pugh C durante un episodio de descompensación. La vitamina K (bisulfito sódico de menadiona) se administró a dosis de 10 mg vía intramuscular cada 12 h durante tres días.  RESULTADOS Se estudiaron 60 pacientes, 30 recibieron vitamina K, en caso de un evento hemorrágico se administró en conjunto terapia de sustitución con plasma fresco congelado y crioprecipitados. La media de edad fue de 60 (25-86) años, todos los casos eran del género masculino. La principal causa de complicación fue la hemorragia (85%). Cinco casos (8.3%) fallecieron por reactivación de la hemorragia. Administrar vitamina K no acortó las pruebas de coagulación (TP, TTPa, INR) ni mostró beneficio en la mortalidad. Sólo la trombosis como la encefalopatía mostró asociación con la mortalidad.  CONCLUSIÓN La adición de vitamina K no influye en las complicaciones en pacientes con enfermedad hepática terminal.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND The administration of vitamin K are restricted to situations such as an antidote for vitamin K antagonists and hemorrhagic disease of the newborn, but due to its role in hemostasis, its use has been extended to other diseases, such as terminal chronic liver disease.  OBJECTIVE  To identify the efficacy of adding vitamin K to the management of patients with terminal hepatic insufficiency with some state of decompensation.  MATERIAL AND METHOD  A retrospective case-control study was done between 2016-2017 in patients with Child-Pugh C chronic liver disease during an episode of decompensation. Vitamin K (menadione sodium bisulfite) was administered at a dose of 10 mg intramuscular every 12 h for three days.  RESULTS A total of 60 patients were studied, 30 received vitamin K, in the case of a hemorrhagic event, replacement therapy with fresh frozen plasma and cryoprecipitates were administered together. The mean age was 60 (25-86) years; all were male. Hemorrhage (85%) was the main cause of complication. Five cases (8.3%) died due to reactivation of the hemorrhage. The administration of vitamin K did not shorten the coagulation tests (TP, aPTT, INR) nor showed a mortality benefit. Only thrombosis such as encephalopathy showed an association on mortality.  CONCLUSION The addition of vitamin K does not influence the complications in patients with terminal liver disease.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Vitamina K]]></kwd>
<kwd lng="es"><![CDATA[enfermedad hepática crónica]]></kwd>
<kwd lng="es"><![CDATA[insuficiencia hepática]]></kwd>
<kwd lng="es"><![CDATA[hemorragia]]></kwd>
<kwd lng="en"><![CDATA[Vitamin K]]></kwd>
<kwd lng="en"><![CDATA[Chronic liver disease]]></kwd>
<kwd lng="en"><![CDATA[Hepatic insufficiency]]></kwd>
<kwd lng="en"><![CDATA[Hemorrhage]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ertel]]></surname>
<given-names><![CDATA[AE]]></given-names>
</name>
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Shah]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Management of gastrointestinal bleeding in patients with cirrhosis]]></article-title>
<source><![CDATA[Curr Prob Surg]]></source>
<year>2016</year>
<volume>53</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>366-95</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lisman]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Stravitz]]></surname>
<given-names><![CDATA[RT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Rebalanced hemostasis in patients with acute liver failure]]></article-title>
<source><![CDATA[Semin Thromb Hemost]]></source>
<year>2015</year>
<volume>41</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>468-73</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lisman]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Leebeek]]></surname>
<given-names><![CDATA[FW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hemostastic alteration in liver disease a review on pathophysiology, clinical consequences and treatment]]></article-title>
<source><![CDATA[Dig Surg]]></source>
<year>2007</year>
<volume>24</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>250-8</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Weeder]]></surname>
<given-names><![CDATA[PD]]></given-names>
</name>
<name>
<surname><![CDATA[Porte]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Lisman]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hemostasis in liver disease implications of new concepts for perioperative management]]></article-title>
<source><![CDATA[Transf Med Rev]]></source>
<year>2014</year>
<volume>28</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>107-13</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reddy]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Civan]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[From Child- Pugh to model for end-stage liver disease deciding who needs a liver transplant]]></article-title>
<source><![CDATA[Med Clin North Am]]></source>
<year>2016</year>
<volume>100</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>449-64</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dogan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gurakar]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Liver transplantation update 2014]]></article-title>
<source><![CDATA[Euroasian J Hepatogastroenterol]]></source>
<year>2015</year>
<volume>5</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>98-106</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kaira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Weed]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Biggins]]></surname>
<given-names><![CDATA[SW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Changing prioritization for transplantation MELD-Na, hepatocellular carcinoma exceptions, and more]]></article-title>
<source><![CDATA[Curr Opin Organ Transplant]]></source>
<year>2016</year>
<volume>21</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>120-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Machicao]]></surname>
<given-names><![CDATA[VI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Model for end -stage liver disease-sodium score the evolution in the prioritization of liver transplantation]]></article-title>
<source><![CDATA[Clin Liver Dis]]></source>
<year>2017</year>
<volume>21</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>275-87</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[El Serafy]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Kassem]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Omar]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Mahfouz]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[El Said]]></surname>
<given-names><![CDATA[El]]></given-names>
</name>
<name>
<surname><![CDATA[Raziky]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[APRI test and hyaluronic acid as non-invasive diagnostic tools for post HCV post liver fibrosis Systematic review and meta-analysis]]></article-title>
<source><![CDATA[Arab J Gastroenterol]]></source>
<year>2017</year>
<volume>18</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>51-7</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khan]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[Fatima-Tuz-Zuhra]]></surname>
</name>
<name>
<surname><![CDATA[Khan]]></surname>
<given-names><![CDATA[FA]]></given-names>
</name>
<name>
<surname><![CDATA[Mubarak]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of diagnostic accuracy of APRI for prediction of fibrosis in hepatitis C patients]]></article-title>
<source><![CDATA[J Ayub Med Coll Abbottabad]]></source>
<year>2008</year>
<volume>20</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>122-6</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García-Tsao]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Current management of the complications of cirrhosis and portal hypertension variceal hemorrhage, ascitis and spontaneous bacterial peritonitis]]></article-title>
<source><![CDATA[Dig Dis]]></source>
<year>2016</year>
<volume>34</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>382-6</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Poordad]]></surname>
<given-names><![CDATA[FF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Presentation and complications associated with cirrhosis of the liver]]></article-title>
<source><![CDATA[Curr Med Res Opin]]></source>
<year>2015</year>
<volume>31</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>925-37</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hartmann]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Szalai]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Saner]]></surname>
<given-names><![CDATA[FH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hemostasis in liver transplantation Pathophysiology, monitoring and treatment]]></article-title>
<source><![CDATA[World J Gastroenterol]]></source>
<year>2016</year>
<volume>22</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1541-50</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Forkin]]></surname>
<given-names><![CDATA[KT]]></given-names>
</name>
<name>
<surname><![CDATA[Colquhoun]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[Nemerqut]]></surname>
<given-names><![CDATA[ECM]]></given-names>
</name>
<name>
<surname><![CDATA[Huffmyer]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The coagulation profile of end-stage liver disease and considerations for intraoperative management]]></article-title>
<source><![CDATA[Anesth Analg]]></source>
<year>2018</year>
<volume>126</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>46-61</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fahrendorff]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveri]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[Johansson]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The use of viscoelastic haemostatic assays in goal-directing treatment with allogeneic blood products - A systematic review and meta-analysis]]></article-title>
<source><![CDATA[Scand J Trauma Resusc Emerg Med]]></source>
<year>2017</year>
<volume>25</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>39</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shah]]></surname>
<given-names><![CDATA[NL]]></given-names>
</name>
<name>
<surname><![CDATA[Intagliata]]></surname>
<given-names><![CDATA[NM]]></given-names>
</name>
<name>
<surname><![CDATA[Northup]]></surname>
<given-names><![CDATA[PG]]></given-names>
</name>
<name>
<surname><![CDATA[Argo]]></surname>
<given-names><![CDATA[CK]]></given-names>
</name>
<name>
<surname><![CDATA[Caldwell]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Procoagulant therapeutics in liver disease a critique and clinical rationale]]></article-title>
<source><![CDATA[Nat Rev Gastroenterol Hepatol]]></source>
<year>2014</year>
<volume>11</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>675-82</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martí-Carbajal]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Cortés-Jofre]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Martí-Peña]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Vitamin K for upper gastrointestinal bleeding in patients with liver diseases]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2008</year>
<volume>16</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>CDD004792</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martí-Carvajal]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Solà]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Vitamin K for upper gastrointestinal bleeding in patients with acute or chronic liver diseases]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2012</year>
<volume>12</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>CD004792</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martí-Carvajal]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Solà]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Vitamin K for upper gastrointestinal bleeding in people with acute or chronic liver diseases]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2015</year>
<numero>6</numero>
<issue>6</issue>
<page-range>CD004792</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Garbuzenko]]></surname>
<given-names><![CDATA[DV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Current approaches to the management of patients with liver cirrhosis who have acute esophageal variceal bleeding]]></article-title>
<source><![CDATA[Curr Med Res Opin]]></source>
<year>2016</year>
<volume>32</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>467-75</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Biecker]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Portal hypertension and gastrointestinal bleeding diagnosis, prevention and management]]></article-title>
<source><![CDATA[World J Gastroenterol]]></source>
<year>2013</year>
<volume>19</volume>
<numero>31</numero>
<issue>31</issue>
<page-range>5035-50</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brunner]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Berziqotti]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bosch]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevention and treatment of variceal haemorrhage in 2017]]></article-title>
<source><![CDATA[Liver Int]]></source>
<year>2017</year>
<volume>37</volume>
<numero>S1</numero>
<issue>S1</issue>
<page-range>104-15</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kravetz]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevention of recurrent esophageal variceal hemorrhage review and current recommendations]]></article-title>
<source><![CDATA[J Clin Gastroenterol]]></source>
<year>2007</year>
<volume>41</volume>
<numero>S3</numero>
<issue>S3</issue>
<page-range>S318-22</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Salim]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Malik]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Farooq]]></surname>
<given-names><![CDATA[MO]]></given-names>
</name>
<name>
<surname><![CDATA[Butt]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Butt]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
<name>
<surname><![CDATA[Alam]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Early initiation of beta blockers following primary endoscopic therapy for bleeding of esophageal varices in cirrhotics]]></article-title>
<source><![CDATA[J Ayub Med Coll Abbottabad]]></source>
<year>2017</year>
<volume>29</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>186-9</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Burza]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Marschall]]></surname>
<given-names><![CDATA[HU]]></given-names>
</name>
<name>
<surname><![CDATA[Napoleone]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Molinaro]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The 35 -years odyssey of betablockers in cirrhosis any gender difference in sight?]]></article-title>
<source><![CDATA[Pharmacol Res]]></source>
<year>2017</year>
<volume>119</volume>
<page-range>20-6</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aggarwal]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Puri]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Lianqpunsakul]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Deep vein thrombosis and pulmonary embolism in cirrhotic patients systematic review]]></article-title>
<source><![CDATA[World J Gastroenterol]]></source>
<year>2014</year>
<volume>20</volume>
<numero>19</numero>
<issue>19</issue>
<page-range>5737-45</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ha]]></surname>
<given-names><![CDATA[NB]]></given-names>
</name>
<name>
<surname><![CDATA[Regal]]></surname>
<given-names><![CDATA[RE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anticoagulation in patients with cirrhosis caught between a rock-liver and a hard place]]></article-title>
<source><![CDATA[Ann Pharmacother]]></source>
<year>2016</year>
<volume>50</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>402-9</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Violi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Corazza]]></surname>
<given-names><![CDATA[GR]]></given-names>
</name>
<name>
<surname><![CDATA[Caldwell]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Perticone]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Gatta]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Angelico]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Portal vein thrombosis relevance on liver cirrhosis Italian Venous Thrombotic Events Registry]]></article-title>
<source><![CDATA[Intern Emerg Med]]></source>
<year>2016</year>
<volume>11</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1059-66</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gîrleanu]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Trifan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cojocariu]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Sîngeap]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The risk of thrombotic events in patients with liver cirrhosis]]></article-title>
<source><![CDATA[Rev Med Chir Soc Med Nat Iasi]]></source>
<year>2012</year>
<volume>116</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>991-6</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Finn]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Carr]]></surname>
<given-names><![CDATA[BI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The growth inhibitory effects of vitamins K and their actions on gene expression]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>1995</year>
<volume>22</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>876-82</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carr]]></surname>
<given-names><![CDATA[BI]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Kar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[K vitamins, PTP antagonism, and cell growth arrest]]></article-title>
<source><![CDATA[J Cell Physiol]]></source>
<year>2002</year>
<volume>193</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>263-74</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Toyoda]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Kumada]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Tada]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Yama]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Differences in the impact of prognostic factors for hepatocellular carcinoma over time]]></article-title>
<source><![CDATA[Cancer Sci]]></source>
<year>2017</year>
<volume>108</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>2438-44</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Meguro]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mizuguchi]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Nishidate]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Okita]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prognostic roles of preoperative a-fetoprotein and des- -carboxy prothrombin in hepatocellular carcinoma patients]]></article-title>
<source><![CDATA[World J Gastroenterol]]></source>
<year>2015</year>
<volume>21</volume>
<numero>16</numero>
<issue>16</issue>
<page-range>4933-45</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Guo]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Artificial neural network models for early diagnosis of hepatocellular carcinoma using serum levels of a-fetoprotein, a-fetoprotein-L3, des-?-carboxy prothrombin, and Golgi protein 73]]></article-title>
<source><![CDATA[Oncotarget]]></source>
<year>2017</year>
<volume>17</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>80521-30</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
