<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662018000100005</article-id>
<article-id pub-id-type="doi">10.24245/mim.v34i1.1545</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Correlación entre hiperfiltración glomerular y proteinuria en pacientes fumadores de mediana edad sin otras comorbilidades]]></article-title>
<article-title xml:lang="en"><![CDATA[Correlation between glomerular hyperfiltration and proteinuria in medium age smoking patients with no other comorbidities]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Piña-Gorráez]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-López]]></surname>
<given-names><![CDATA[VH]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Elizalde-Barrera]]></surname>
<given-names><![CDATA[CI]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arias-Sánchez]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Ticomán  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital General Ticomán  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital General Tláhuac  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af4">
<institution><![CDATA[,IMSS  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2018</year>
</pub-date>
<volume>34</volume>
<numero>1</numero>
<fpage>29</fpage>
<lpage>37</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662018000100005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662018000100005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662018000100005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES: En México los reportes mencionan entre 114 y 122 decesos diarios asociados con el tabaquismo. En 2011, Hallan y Orth publicaron los resultados de un seguimiento a 10 años de más de 65,000 participantes, concluyeron que el riesgo de insuficiencia renal es tres a cuatro veces mayor en fumadores que en no fumadores.  OBJETIVO: Demostrar que el consumo del tabaco en pacientes sin comorbilidades puede favorecer la hiperfiltración glomerular, aumentado así el riesgo de enfermedad renal crónica.  MATERIAL Y MÉTODO:  Estudio transversal analítico, prospectivo, efectuado con pacientes del Hospital General Xoco, que se dividieron en dos grupos. Se tomaron muestras de sangre para obtener las concentraciones séricas de creatinina y urea; con las fórmulas MDRD y CKD EPI se estimó la tasa de filtración glomerular. El análisis estadístico se realizó con el programa SPSS V21.  RESULTADOS: Se incluyeron 152 pacientes. La mayoría de la población fumadora tenía dependencia alta con 20 casos y prevalencia de 27%, con valor de p = 0.023 para la tasa de filtración glomerular por la fórmula MDRD y p = 0.006 por CKD-EPI, con diferencias estadísticamente significativas. Se demostró una correlación positiva estadísticamente significativa (r = 0.413, p &lt; 0.01) entre el índice tabáquico y la tasa de filtración glomerular medida por MDRD. De igual manera, se encontró correlación positiva estadísticamente significativa (r = 0.238, p = 0.041) entre el índice tabáquico y la tasa de filtración glomerular medida por CKD-EPI.  CONCLUSIÓN: El tabaquismo condiciona mayor hiperfiltración glomerular en comparación con los no fumadores; esta relación es dosis-dependiente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND: In Mexico the reports mention between 114 and 122 daily deaths associated with smoking. In 2011, Hallan and Orth published the results of a 10-year follow-up of more than 65,000 participants, concluding that the risk of developing renal failure is 3 to 4 times higher in smokers than in non-smokers.  OBJECTIVE: To demonstrate how the use of tobacco in patients without comorbidities may favor glomerular hyperfiltration, thus increasing the risk of chronic kidney disease.  MATERIAL AND METHOD:  A cross-sectional, analytical, prospective study was conducted with patients from the Xoco General Hospital, Mexico City; they were divided into 2 groups. Blood samples were taken to obtain the serum creatinine and urea values, using the MDRD and CKD formulas. EPI estimated the glomerular filtration rate. Statistical analysis was performed with the SPSS V21 program.  RESULTS: There were included 152 patients. Majority of the smoking population had high dependence with 20 cases and a prevalence of 27%. With a value of p = 0.023 for glomerular filtration rate (GFR) by MDRD and p = 0.006 for CKD-EPI. They had statistically significant differences. A statistically significant positive correlation (r = 0.413, p &lt; 0.01) between the smoking index and the GFR measured by MDRD was demonstrated in this study. Statistically significant positive correlation (r = 0.238, p = 0.041) was also found between smoking index and GFR measured by CKD-EPI.  CONCLUSION: Smoking causes high glomerular hyperfiltration compared to not-smoking subjects; this relation is dosis-dependent.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Tabaquismo]]></kwd>
<kwd lng="es"><![CDATA[proteinuria]]></kwd>
<kwd lng="en"><![CDATA[Smoking]]></kwd>
<kwd lng="en"><![CDATA[Proteinuria]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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