<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662017000400515</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Taupatía en la enfermedad de Alzheimer]]></article-title>
<article-title xml:lang="en"><![CDATA[Taupathy in Alzheimer's disease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fuente-Rocha]]></surname>
<given-names><![CDATA[Javier de la]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UNAM Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2017</year>
</pub-date>
<volume>33</volume>
<numero>4</numero>
<fpage>515</fpage>
<lpage>521</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662017000400515&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662017000400515&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662017000400515&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: En la fisiopatología de la enfermedad de Alzheimer durante mucho tiempo se ha dado mayor importancia al estudio del beta amiloide. A la luz de los conocimientos actuales también debe considerarse la participación de las vías de cinasas activadas por el receptor de insulina a nivel neuronal y particularmente a nivel del hipocampo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: In the pathophysiology of Alzheimer's disease, the study of amyloid beta has long been of great importance. In light of current knowledge, the involvement of insulin receptor activated kinase pathways at the neuronal level and particularly at the hippocampus levels should also be considered.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[taupatía]]></kwd>
<kwd lng="es"><![CDATA[cinasas]]></kwd>
<kwd lng="es"><![CDATA[fosforilaciones]]></kwd>
<kwd lng="es"><![CDATA[insulina]]></kwd>
<kwd lng="en"><![CDATA[taupathy]]></kwd>
<kwd lng="en"><![CDATA[kinases]]></kwd>
<kwd lng="en"><![CDATA[phosphorylation]]></kwd>
<kwd lng="en"><![CDATA[insulin]]></kwd>
</kwd-group>
</article-meta>
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