<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662017000300381</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Choque séptico. Lo que sabíamos y lo que debemos saber...]]></article-title>
<article-title xml:lang="en"><![CDATA[Septic shock. What we knew and what we should know...]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Gómez]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Luna]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Beltrán]]></surname>
<given-names><![CDATA[CF]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Greene]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Weber]]></surname>
<given-names><![CDATA[FL]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad La Salle Facultad Mexicana de Medicina Hospital Ángeles Pedregal]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad La Salle Facultad Mexicana de Medicina Hospital Ángeles Pedregal]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad La Salle Facultad Mexicana de Medicina Hospital Ángeles Pedregal]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<volume>33</volume>
<numero>3</numero>
<fpage>381</fpage>
<lpage>391</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662017000300381&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662017000300381&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662017000300381&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen En el mundo, la prevalência de sepsis es de más de 19 millones de casos por año, con mortalidad estimada de 30%. Los factores de riesgo identificados más frecuentemente son las enfermedades crónicas (VIH-SIDA, EPOC y neoplasias), así como la administración de agentes inmunosupresores. La población más susceptible de padecer estas complicaciones es la que se encuentra en los extremos de la vida. De los múltiples agentes patógenos, las bacterias son los microorganismos principalmente implicados en la aparición de la sepsis grave. Entre los focos infecciosos, en primer lugar está la neumonía, seguida de infecciones intraabdominales, de las vías urinarias e infecciones primarias del torrente sanguíneo. Se ha demostrado que el tratamiento temprano aumenta la supervivencia de manera significativa. Las intervenciones que deben realizarse incluyen: tratamiento antimicrobiano, resucitación hídrica, apoyo ventilatorio y tratamiento de soporte (profilaxis antitrombótica, control de la glucemia y profilaxis para evitar úlceras gástricas por estrés y nutrición, entre otras medidas).]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Globally, the prevalence of sepsis is more than 19 million cases per year with an estimated mortality of 30%. The most frequently identified risk factors are chronic diseases (HIV-AIDS, COPD and neoplasms) and the use of immunosuppressive agents. The most susceptible popula tion to develop these complications are the ones in babyhood or the elderly. Among the multiple pathogens, bacteria are considered the microorganisms primarily involved in the development of severe sepsis. Within the foci of infection, pneumonia is considered to be the most common, followed by intra-abdominal infections, urinary tract and primary bloodstream infections. It has been demonstrated that early treatment significantly improves survival. Interventions to be performed include antimicrobial therapy, fluid resuscitation, ventilatory support and supportive measures (antithrombotic prophylaxis, glycemic control and prophylaxis to prevent stress gastric ulcers and nutrition).]]></p></abstract>
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<kwd lng="es"><![CDATA[choque séptico]]></kwd>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[septic shock]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
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