<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662017000300335</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Diferencia sodio-cloro e índice cloro/sodio como predictores de mortalidad en choque séptico]]></article-title>
<article-title xml:lang="en"><![CDATA[Sodium-chloride difference and chloride/sodium ratio as predictors of mortality in septic shock]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cortés-Román]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Díaz]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Méndez]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Rodríguez]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peniche-Moguel]]></surname>
<given-names><![CDATA[KG]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Gutiérrez]]></surname>
<given-names><![CDATA[SP]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pin-Gutiérrez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivera-Solís]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Huanca-Pacaje]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castañeda-Balladares]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calyeca-Sánchez]]></surname>
<given-names><![CDATA[MV]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,IMSS Hospital de Especialidades Núm. 14 ]]></institution>
<addr-line><![CDATA[ Veracruz]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,IMSS Hospital de Especialidades Núm. 14 Departamento de Medicina Crítica]]></institution>
<addr-line><![CDATA[ Veracruz]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,IMSS Hospital de Especialidades Núm. 14 Departamento de Cuidados Intensivos Coronarios]]></institution>
<addr-line><![CDATA[ Veracruz]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,IMSS Hospital de Especialidades Núm. 14 ]]></institution>
<addr-line><![CDATA[ Veracruz]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Veracruzana Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ Veracruz]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<volume>33</volume>
<numero>3</numero>
<fpage>335</fpage>
<lpage>343</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662017000300335&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662017000300335&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662017000300335&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES: la hipercloremia es la causa más frecuente de acidosis metabólica en pacientes en estado crítico. La diferencia sodio-cloro (Na+-Cl-) y el índice cloro/sodio (Cl-/Na+) pueden valorar de manera simple el papel de la hipercloremia en las alteraciones ácido-base.  OBJETIVO: determinar si la diferencia sodio-cloro y el índice cloro/ sodio medidos a las 24 horas de ingreso son predictores de mortalidad a 30 días en pacientes con choque séptico.  MATERIAL Y MÉTODO: estudio de cohorte prospectivo, longitudinal, descriptivo y analítico. Se incluyeron los pacientes con diagnóstico de choque séptico según las Guías de la Campaña Sobreviviendo a la Sepsis del año 2012, ingresados a la Unidad de Cuidados Intensivos en el periodo comprendido de junio del 2015 a junio de 2016.  RESULTADOS: el análisis multivariado mostró que la diferencia Na+-Cl- menor de 31 mEq/L incrementa el riesgo de muerte en los pacientes con choque séptico a 30 días, OR 15.26 (IC95% 1.56-148.49) p=0.019.  CONCLUSION: la disminución de la diferencia Na+-Cl- por debajo de 31 mEq/L condicionada por hipercloremia incrementa el riesgo de muerte a 30 días en el paciente con choque séptico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND: Hyperchloremia is the most common cause of metabolic acidosis in critically ill patients. The sodium-chloride difference (Na+-Cl-) and chloride/sodium ratio (Cl-/Na+) may simply evaluate the role of hyperchloremia in acid-base disturbances.  OBJECTIVE: To determine if sodium-chloride difference and chloride/ sodium ratio measured at 24 h of admission are mortality predictors at 30 days in patients with septic shock.  MATERIAL AND METHOD: A prospective cohort, longitudinal, descriptive and analytic study was done including patients diagnosed with septic shock according to the guidelines of the Surviving Sepsis Campaign in 2012, admitted to the Intensive Care Unit in the period comprising from June 2015 to June 2016.  RESULTS: The multivariate analysis showed that the Na+-Cl- difference less than 31 mEq/L increases the risk of death in patients with septic shock at 30 days, OR 15.26 (95% CI 1.56-148.49) p=0.019.  CONCLUSION: The decrease in the Na+-Cl- difference below 31 mEq/L conditioned by hyperchloremia increases the risk of death at 30 days in the patient with septic shock.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[choque séptico]]></kwd>
<kwd lng="es"><![CDATA[hipercloremia]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="es"><![CDATA[unidad de cuidados intensivos]]></kwd>
<kwd lng="en"><![CDATA[septic shock]]></kwd>
<kwd lng="en"><![CDATA[hyperchloremia]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
<kwd lng="en"><![CDATA[Intensive Care Unit]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Severe sepsis and septic shock]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Angus]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
<name>
<surname><![CDATA[Van der Poll]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[N Engl J Med]]></source>
<year>2013</year>
<volume>369</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>840-51</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock 2012]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dellinger]]></surname>
<given-names><![CDATA[RP]]></given-names>
</name>
<name>
<surname><![CDATA[Levy]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Rhodes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care Med]]></source>
<year>2013</year>
<volume>41</volume>
<page-range>580-637</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[US Burden of Disease Collaborators. The state of US health, 1990-2010: burden of diseases, injuries, and risk factors]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Murray]]></surname>
<given-names><![CDATA[CJ]]></given-names>
</name>
<name>
<surname><![CDATA[Atkinson]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Bhalla]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[JAMA]]></source>
<year>2013</year>
<volume>310</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>591-608</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Torio]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Andrews]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
</person-group>
<source><![CDATA[National Inpatient Hospital Costs: The Most Expensive Conditions by Payer, 2011]]></source>
<year></year>
<publisher-name><![CDATA[Healthcare Cost and Utilization Project (HCUP) Statistical Briefs]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Unaccounted for anion in metabolic acidosis during severe sepsis in humans]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mecher]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Rackow]]></surname>
<given-names><![CDATA[EC]]></given-names>
</name>
<name>
<surname><![CDATA[Astiz]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care Med]]></source>
<year>1991</year>
<volume>19</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>705-11</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hyperchloremia is the dominant cause of metabolic acidosis in the postresuscitation phase of pediatric meningococcal sepsis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[O'Dell]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Tibby]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Durward]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care Med]]></source>
<year>2007</year>
<volume>35</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2390-4</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Evolutive standard base excess and serum lactate level in severe sepsis and septic shock patients resuscitated with early goal-directed therapy Still outcome markers?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Azevedo]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
<name>
<surname><![CDATA[Maciel]]></surname>
<given-names><![CDATA[AT]]></given-names>
</name>
</person-group>
<source><![CDATA[Clinics]]></source>
<year>2006</year>
<volume>61</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>47-52</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Base excess and lactate as prognostic indicators for patients admitted to intensive care]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Molloy]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Intensive Care Med]]></source>
<year>2001</year>
<volume>27</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>74-83</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Lactate versus non-lactate metabolic acidosis a retrospective outcome evaluation of critically ill patients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gunnerson]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Saul]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[He]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care]]></source>
<year>2006</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>R22</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinical review the meaning of acid-base abnormalities in the intensive care unit part I-epidemiology]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gunnerson]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care]]></source>
<year>2005</year>
<volume>9</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>508-16</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Differences in acid-base behavior between intensive care unit survivors and nonsurvivors using both a physicochemical and a standard base excess approach a prospective, observational study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maciel]]></surname>
<given-names><![CDATA[AT]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[J Crit Care]]></source>
<year>2009</year>
<volume>24</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>477-83</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Metabolic acidosis in patients with severe sepsis and septic shock a longitudinal quantitative study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Noritomi]]></surname>
<given-names><![CDATA[DT]]></given-names>
</name>
<name>
<surname><![CDATA[Soriano]]></surname>
<given-names><![CDATA[FG]]></given-names>
</name>
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care Med]]></source>
<year>2009</year>
<volume>37</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2733-9</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Modern quantitative acid-base chemistry]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stewart]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
</person-group>
<source><![CDATA[Can J Physiol Pharmacol]]></source>
<year>1983</year>
<volume>61</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1444-61</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hyperchloraemic acidosis another misnomer?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Story]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care Resusc]]></source>
<year>2004</year>
<volume>6</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>188-92</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Fluid resuscitation and hyperchloremic acidosis in experimental sepsis Improved short-term survival and acid-base balance with Hextend compared with saline]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care Med]]></source>
<year>2002</year>
<volume>30</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>300-5</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hyperchloremic acidosis increases circulating inflammatory molecules in experimental sepsis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Almasri]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Chest]]></source>
<year>2006</year>
<volume>130</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>962-7</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically Ill adults]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yunos]]></surname>
<given-names><![CDATA[NM]]></given-names>
</name>
<name>
<surname><![CDATA[Bellomo]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Hegarty]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[JAMA]]></source>
<year>2012</year>
<volume>308</volume>
<numero>15</numero>
<issue>15</issue>
<page-range>1566-72</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Lactic and hydrochloric acids induce different patterns of inflammatory response in LPS-stimulated RAW 264 7 cells]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Physiol Regul Integr Comp Physiol]]></source>
<year>2004</year>
<volume>286</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>R686-92</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The value of the chloride sodium ratio in differentiating the etiology of metabolic acidosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Durward]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Skellett]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Mayer]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Intensive Care Med]]></source>
<year>2001</year>
<volume>27</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>828-35</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Acid-base and electrolyte analysis in critically ill patients are we ready for the new millennium?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gunnerson]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr Opin Crit Care]]></source>
<year>2003</year>
<volume>9</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>468-73</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Acid-base physiology: the &#8220;traditional&#8221; and the &#8220;modern&#8221; approaches]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sirker]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Rhodes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Grounds]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
</person-group>
<source><![CDATA[Anaesthesia]]></source>
<year>2002</year>
<volume>57</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>348-56</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Consensus on circulatory shock and hemodynamic monitoring Task force of the European Society of Intensive Care Medicine]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cecconi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[De Backer]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Antonelli]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Intensive Care Med]]></source>
<year>2014</year>
<volume>40</volume>
<page-range>1795-815</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Lactic versus non-lactic metabolic acidosis outcomes in critically ill patients. Abstract]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gunnerson]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Saul]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care]]></source>
<year>2003</year>
<volume>7</volume>
<numero>^s2</numero>
<issue>^s2</issue>
<supplement>2</supplement>
<page-range>S8-9</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Understanding acid--base balance]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Durward]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Murdoch]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Current Pediatrics]]></source>
<year>2003</year>
<volume>13</volume>
<page-range>513-9</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Fluids, pH, ions and electrolytes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kaplana]]></surname>
<given-names><![CDATA[LJ]]></given-names>
</name>
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<source><![CDATA[Current Opinion in Critical Care]]></source>
<year>2010</year>
<volume>16</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>323-33</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Physiological effects of hyperchloraemia and acidosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Handy]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Soni]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[Br J Anaesth]]></source>
<year>2008</year>
<volume>101</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>141-50</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRS]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shaw]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
<name>
<surname><![CDATA[Raghunathan]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Peyerl]]></surname>
<given-names><![CDATA[FW]]></given-names>
</name>
</person-group>
<source><![CDATA[Intensive Care Med]]></source>
<year>2014</year>
<volume>40</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1897-905</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Causes and effects of hyperchloremic acidosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Eisenhut]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Critical Care]]></source>
<year>2006</year>
<volume>10</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>413</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effects of hyper-chloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Venkataraman]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Chest]]></source>
<year>2004</year>
<volume>125</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>243-8</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Meta-analysis of high- versus low-chloride content in perioperative and critical care fluid resuscitation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Krajewski]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Raghunathan]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Paluszkiewicz]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
</person-group>
<source><![CDATA[Br J Surg]]></source>
<year>2015</year>
<volume>102</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>24-36</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hyperchlo-remia after noncardiac surgery is independently associated with increased morbidity and mortality A propensity-matched cohort study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[McCluskey]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Karkouti]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Wijeysundera]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Anesth Analg]]></source>
<year>2013</year>
<volume>117</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>412-21</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The use of sodium-chloride difference and chloride-sodium ratio as strong ion difference surrogates in the evaluation of metabolic acidosis in critically ill patients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nagaoka]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Nassar]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Toledo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[J Crit Care]]></source>
<year>2010</year>
<volume>25</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>525-3</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Unmeasured anions and mortality in critically ill patients in 2016]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kotake]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[J Intensive Care]]></source>
<year>2016</year>
<volume>4</volume>
<page-range>45</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
