<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662017000200159</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Crisis asmática grave asociada con infección viral]]></article-title>
<article-title xml:lang="en"><![CDATA[Severe asthmatic crisis related to viral infection]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Herrera-García]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arellano-Montellano]]></surname>
<given-names><![CDATA[El]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Paulin-Prado]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Zenteno]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez-Venegas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Caballero-López]]></surname>
<given-names><![CDATA[CG]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jaramillo-Arellano]]></surname>
<given-names><![CDATA[LE]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Espinosa-Arellano]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario de Puebla Departamento de Asma y EPOC ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario de Puebla Subdirección de Enseñanza ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Enfermedades Respiratorias Departamento de Enfermedades Respiratorias Obstructivas Crónicas ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af4">
<institution><![CDATA[,Benemérita Universidad Autónoma del Estado de Puebla Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<volume>33</volume>
<numero>2</numero>
<fpage>159</fpage>
<lpage>167</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662017000200159&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662017000200159&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662017000200159&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES: 50% de las crisis asmáticas son desencadenadas por infecciones virales, su relación con parámetros clínicos no se ha descrito en los adultos.  OBJETIVO: determinar la prevalencia de crisis asmáticas de acuerdo con el espectro viral y su asociación con características clínicas y mecánica respiratoria.  MATERIAL Y MÉTODO: estudio clínico, prospectivo y observacional en el que se incluyeron pacientes con crisis asmática grave del 1 de diciembre de 2010 al 31 de diciembre de 2011. Se excluyeron los pacientes con sospecha de infección bacteriana. Se aplicó cuestionario de síntomas, se determinó panel viral por hisopado nasal, espirometría y estudios de laboratorio. Se obtuvo el consentimiento informado de los participantes.  RESULTADOS: se incluyeron en el estudio 100 pacientes. La edad promedio fue de 39±14 años, IMC 27±4 kg/m2, escala de Borg 6.2±1.2, escala mMRC 2.6±0.6, tiempo de los síntomas 7±7 días, FEV1 de 42±14%, oximetría de pulso 88±3% y estancia de 4.5±1.7 días. El 47% de los pacientes tenía rinitis alérgica. Se aisló virus en 36% (rinovirus 15% y coronavirus 6%). Al comparar la causa viral vs no viral, se observó que los pacientes eran menores en el primer grupo (36±13 vs 43±17 años, p=0.014); no hubo diferencia entre grado de obstrucción y síntomas. A mayor severidad del asma hubo más aislamientos de virus.  CONCLUSIÓN: las crisis asmáticas asociadas con virus respiratorios tienen comportamiento clínico similar al de las no asociadas. En los pacientes con menor edad y con comportamiento más grave se aíslan virus con más frecuencia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND: 50% of asthma attacks are triggered by viral in fections; its relationship with clinical parameters has not been described in adults.  OBJECTIVE: To determine the prevalence of asthma attacks according to viral spectrum and its association with clinical features and respiratory mechanics.  MATERIAL AND METHOD: A clinical, prospective and observational study with patients with severe asthma attended from December 1st 2010 to December 31st 2011. We excluded patients with suspected bacterial infection. Symptom questionnaire was applied, it was determined by nasal swab viral panel, spirometry and laboratory studies. Informed consent was obtained.  RESULTS: One hundred patients were included. Mean age was 39±14 years, BMI 27±4 kg/m2, Borg 6.2±1.2, mMRC 2.6±0.6, length of symptoms 7±7 days and FEV1 of 42±14%, pulse oximetry 88±3% and stay 4.5±1.7 days; 47% of patients had allergic rhinitis. Virus was isolated in 36% (15% rhinovirus and 6% coronavirus). Comparing the non-viral vs viral etiology, patients were younger (36±13 vs 43±17 years, p=0.014) there was no difference between the degree of obstruction and symptoms. A greater severity of asthma was related to more isolation.  CONCLUSION: Asthma attacks associated with respiratory viruses have similar clinical behavior to not associated ones. In younger patients with more severe behavior virus are isolated more frequently.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[crisis asmática]]></kwd>
<kwd lng="es"><![CDATA[virus respiratorios]]></kwd>
<kwd lng="es"><![CDATA[síntomas]]></kwd>
<kwd lng="es"><![CDATA[aislamiento]]></kwd>
<kwd lng="en"><![CDATA[acute asthma]]></kwd>
<kwd lng="en"><![CDATA[respiratory viruses]]></kwd>
<kwd lng="en"><![CDATA[symptoms]]></kwd>
<kwd lng="en"><![CDATA[isolation]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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