<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-2391</journal-id>
<journal-title><![CDATA[Acta pediátrica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Acta pediatr. Méx]]></abbrev-journal-title>
<issn>0186-2391</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Pediatría]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-23912017000600394</article-id>
<article-id pub-id-type="doi">10.18233/apm38no6pp394-4011507</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Leucemias neonatales: experiencia en el Hospital Infantil de México Federico Gómez (HIMFG)]]></article-title>
<article-title xml:lang="en"><![CDATA[Neonatal leukaemia: in the Hospital Infantil de México Federico Gómez. (HIMFG) Experience]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ibarra-Ríos]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zapata-Tarres]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villanueva-García]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peña-del Castillo]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dorantes-Acosta]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Juárez-Villegas]]></surname>
<given-names><![CDATA[LE]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Infantil de México Federico Gómez Unidad de Cuidados Neonatales ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Pediatría Servicio de Oncología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Infantil de México Federico Gómez Servicio de Neonatología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Nacional de Pediatría  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital Infantil de México Federico Gómez Servicio de Oncología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Hospital Infantil de México Federico Gómez Departamento de Hemato-Oncología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<volume>38</volume>
<numero>6</numero>
<fpage>394</fpage>
<lpage>401</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-23912017000600394&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-23912017000600394&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-23912017000600394&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  INTRODUCCIÓN:  la leucemia neonatal (o congénita) es aquella diagnosticada en los primeros 30 días tras el nacimiento. Su incidencia se reporta en 1 a 5 por cada millón de recién nacidos vivos (corresponde a menos del 1% de las leucemias en pediatría).  OBJETIVO:  describir los casos diagnosticados en el Hospital Infantil de México Federico Gómez (HIMFG).  PRESENTACIÓN DE LA SERIE DE CASOS: se incluyó pacientes menores de 30 días a los cuales se les realizó el diagnóstico morfológico de leucemias entre el 1º de enero de 1990 y el 1º de junio del 2012 en el HIMFG.  RESULTADOS:  en los 12 años del estudio se identificaron 3,061 casos de leucemias, de los cuales sólo cinco expedientes correspondieron a leucemias neonatales. Se describen tres pacientes femeninos y dos masculinos, con edad media al diagnóstico de 21 días (17-26 días), tratándose con mayor frecuencia de leucemia mieloide (LMA) en tres casos (60%) y leucemia linfoide en dos pacientes. Un caso de LMA asociado a síndrome de Down. En ningún caso se encontraron translocaciones de riesgo. Cuatro pacientes (80%) recibieron manejo para síndrome de lisis tumoral. Cuatro pacientes fallecieron con una mediana de edad de 84 días (57-176 días). El paciente que sobrevivió recibió tratamiento con doxorrubicina y metotrexate al 50% y en su último seguimiento a los tres años de edad continuaba en remisión.  CONCLUSIONES:  la presentación de los casos corresponde a la reportada en literatura con respecto a frecuencias de leucemias linfoides y mieloides. La supervivencia global a largo plazo fue del 20% (33% para las mieloides) con un solo paciente en remisión. Este padecimiento tiene un pronóstico fatal que puede mejorar con el diagnóstico oportuno (incluso prenatal) y manejo con quimioterapia intensiva. Ésta es la serie más grande de leucemias neonatales reportada en México.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKROUND:  Neonatal leukaemia is the one diagnosed in the first 30 days of life. Its incidence is reported in 1 to 5 per million of newborns (it represents less than 1% of leukaemias).  CASES PRESENTATION: We describe all cases diagnosed with neonatal leukaemia between January 1st 1990 and November 1, 2012 at our institution. We searched for all medical records labelled under the diagnosis of leukaemia, and we selected those in which the diagnosis was done in the first 30 days of life. A total of 3,061 medical records were labelled as leukaemia, from which only 5 (0.16%) corresponded to neonatal leukaemia. Affected patients were three females and 2 males with a median age at diagnosis was 21 days (17-26 days). Three cases were acute myeloid leukaemia and two acute lymphoid leukaemia. One patient had Down syndrome. Four patients developed tumoral lysis syndrome. Four patients died at a median age of 84 days (57-176 days). The only survivor patient received complete 50% reduced ATEDox NOPHO protocol, with a last follow-up visit at age 3 years were he has reported free of disease.  CONCLUSIONS:  We describe the largest cases series in Mexico of neonatal leukaemia.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[leucemia neonatal]]></kwd>
<kwd lng="es"><![CDATA[leucemia aguda linfoide]]></kwd>
<kwd lng="es"><![CDATA[leucemia aguda mieloide serie de casos]]></kwd>
<kwd lng="en"><![CDATA[neonatal leukaemia]]></kwd>
<kwd lng="en"><![CDATA[neonatal cancer]]></kwd>
<kwd lng="en"><![CDATA[acute lymphoid leukaemia]]></kwd>
<kwd lng="en"><![CDATA[acute myeloid leukaemia]]></kwd>
<kwd lng="en"><![CDATA[infant]]></kwd>
<kwd lng="en"><![CDATA[newborn]]></kwd>
<kwd lng="en"><![CDATA[precursor cell lymphoblastic leukaemia]]></kwd>
<kwd lng="en"><![CDATA[leukaemia myeloid acute]]></kwd>
</kwd-group>
</article-meta>
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