<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-2391</journal-id>
<journal-title><![CDATA[Acta pediátrica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Acta pediatr. Méx]]></abbrev-journal-title>
<issn>0186-2391</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Pediatría]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-23912015000600464</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tumor germinal mixto con componentes de disgerminoma y coriocarcinoma de ovario en mujer adolescente con ataxia-telangiectasia]]></article-title>
<article-title xml:lang="en"><![CDATA[Germ cell ovarian tumor in an adolescent with ataxia-telangiectasia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gálvez-Cuitiva]]></surname>
<given-names><![CDATA[Eduardo Augusto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ridaura-Sanz]]></surname>
<given-names><![CDATA[Cecilia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yamazaki-Nakashimada]]></surname>
<given-names><![CDATA[Marco Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leal-Leal]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zapata-Tarrés]]></surname>
<given-names><![CDATA[Marta]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Pediatría  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Pediatría Departamento de Patología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Pediatría Servicio de Inmunología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Nacional de Pediatría Servicio de Oncología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2015</year>
</pub-date>
<volume>36</volume>
<numero>6</numero>
<fpage>464</fpage>
<lpage>472</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-23912015000600464&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-23912015000600464&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-23912015000600464&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN:  Antecedentes:  la ataxia-telangiectasia es una enfermedad hereditaria con patrón de herencia autosómico recesivo. Se caracteriza por deterioro neurológico, telangiectasias e inmunodeficiencia. Su causa es una mutación en el gen ATM (ataxia telangiectasia mutated) localizado en el cromosoma 11q22.3-23.1, relacionado con la síntesis de una proteína con actividad fosfoinositol-3-cinasa que participa en la regulación del ciclo celular y en la reparación del ácido desoxirribonucleico; esto explica, en parte, la susceptibilidad al desarrollo de neoplasias. Su asociación con algunos tipos de cáncer se ha establecido previamente y la mayor incidencia es con leucemias y linfomas. Se han reportado siete niñas con ataxia-telangiectasia asociada con tumores sólidos germinales, específicamente con disgerminoma.  Caso clínico:  mujer adolescente de 12 años con diagnóstico de ataxia-telangiectasia desde los tres años. Tuvo infecciones repetidas de las vías respiratorias que requirieron múltiples hospitalizaciones de dos a tres veces por mes; recibió tratamiento con inmunoglobulina y profilaxis antimicrobiana. A los 12 años acudió al servicio de urgencias con abdomen agudo; fue operada y se halló una masa abdominopélvica que se extirpó. El diagnóstico fue de tumor germinal mixto con componente de disgerminoma y coriocarcinoma de ovario. Recibió un primer ciclo de quimioterapia con bleomicina (10 UI/m2/día, una dosis), ciclofosfa-mida (1 g/m2/día por cuatro días) y cisplatino (20 mg/m2/dosis por cinco días). Se suspendió la quimioterapia porque desarrolló choque séptico que puso en riesgo su vida. Por su enfermedad de base permaneció bajo vigilancia. Actualmente, 17 meses después, la paciente vive sin actividad tumoral.  Conclusión:  existe asociación entre ataxia-telangiectasia, leucemia y linfomas. Se describe el caso clínico de una paciente con ataxia-telan-giectasia y tumor germinal mixto con componente de disgerminoma y coriocarcinoma de ovario. Se propone establecer un tratamiento especial para estos pacientes inmunocomprometidos, con alto riesgo de cáncer pero, a la vez, de no tolerar los esquemas habituales.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT:  Background:  Ataxia-telangiectasia (AT) is an autosomal recessive hereditary disease characterized by neurological deterioration, telangiectasias and immunodeficiency. The cause is a punctual mutation in ATM gene localized in chromosome 11q22.3-23.1, which translates into a phosphoinositol 3-kinase protein. This protein regulates the cell cycle and the repair of the DNA. This defect partially explains the increased risk of cancer. The association of the AT with cancer has been already established, being the major incidence of leukemias and lymphomas. In the literature, seven girls have been reported with the association of AT and germ cell solid tumors, specifically with dysgerminoma.  Case report:  We present the case of a 12-year-old female who was diagnosed with AT since 3 years of age. She presented recurrent respiratory tract infections requiring multiple hospitalizations and was treated with immunoglobulin and antimicrobial prophylaxis. She was admitted in the emergency ward with acute abdomen and was evaluated by surgical oncology and operated. An abdominal mass was found and resected. Pathology reported an ovaric mixed germ cell tumor with coriocarcinoma and dysgerminoma. She was treated with one dose of bleomicin (10 UI/m2), cyclophosphamide (1 g/m2/day for four days) and cysplatin (20 mg/m2/day for five days). During chemotherapy she presented a live threatening septic shock. Because of AT it was decided to stop chemotherapy. At present, the patient is alive without tumor activity for 17 months.  Conclusion:  AT is associated with leukemias and lymphomas. We report a case of an AT patient with ovarian tumor, coriocarcinoma and dysgerminoma components. A special approach is proposed for these inmunocompromised patients who are leaving more and are at high risk of cancer but may not tolerate standard treatments.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[tumor germinal de ovario]]></kwd>
<kwd lng="es"><![CDATA[disgerminoma]]></kwd>
<kwd lng="es"><![CDATA[coriocarcinoma]]></kwd>
<kwd lng="es"><![CDATA[adolescente]]></kwd>
<kwd lng="es"><![CDATA[ataxia-telangiectasia]]></kwd>
<kwd lng="en"><![CDATA[Cancer of ovary]]></kwd>
<kwd lng="en"><![CDATA[dysgerminoma]]></kwd>
<kwd lng="en"><![CDATA[choriocarcinoma]]></kwd>
<kwd lng="en"><![CDATA[adolescent]]></kwd>
<kwd lng="en"><![CDATA[ataxia telangiectasia]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia Queensland Institute of medical Research, Brisbane]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lavin]]></surname>
<given-names><![CDATA[MF]]></given-names>
</name>
<name>
<surname><![CDATA[Gueven]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Bottle]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gatti]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
</person-group>
<source><![CDATA[Australia Br Med Bull]]></source>
<year>2007</year>
<volume>81</volume>
<page-range>129-47</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ataxia-telangiectasia and related diseases]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Frappart]]></surname>
<given-names><![CDATA[PO]]></given-names>
</name>
<name>
<surname><![CDATA[McKinnon]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Neuromolecular]]></source>
<year>2006</year>
<volume>8</volume>
<page-range>495:511</page-range><publisher-loc><![CDATA[Memphis ]]></publisher-loc>
<publisher-name><![CDATA[Department of genetics and tumour biology. St Jude Childrens Research Hospital]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Pathogenesis of ataxia-telangiectasia the next generation ATM functions. University of Tasmania. Australia. Department of molecular biology. UCLA school of Medicine. Los Angeles, CA]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ambrose]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gatti]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Blood]]></source>
<year>2013</year>
<volume>121</volume>
<page-range>4036-45</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Telomeric protein Pin2/TRF1 as un important ATM target in response to double stran DNA breaks]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kishi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Xz]]></surname>
<given-names><![CDATA[Zho]]></given-names>
</name>
<name>
<surname><![CDATA[Ziv]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[khoo]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Hill]]></surname>
<given-names><![CDATA[DE]]></given-names>
</name>
</person-group>
<source><![CDATA[J Boil Chem]]></source>
<year>2011</year>
<volume>276</volume>
<numero>20</numero>
<issue>20</issue>
<page-range>16587-93</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Banin]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ouyang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[GC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ATM is required for Ikappa B kinase activation in reponse to DNA doauble strand breaks]]></article-title>
<collab>courtis G et al</collab>
<source><![CDATA[J Biol Chen]]></source>
<year>2001</year>
<volume>276</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>898-903</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ataxia telangiectasia gene linked to insulin function]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kastan]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Cell Biol]]></source>
<year>2000</year>
<volume>12</volume>
<page-range>893</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The molecular basis and clinical management of ataxia telangiectasia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Spacey]]></surname>
<given-names><![CDATA[SD]]></given-names>
</name>
<name>
<surname><![CDATA[Gatti]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Bebb]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Can J Neurol Sci]]></source>
<year>2000</year>
<volume>27</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>184-91</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia]]></article-title>
<collab>FIGO Committee on Gynecologic Oncology</collab>
<source><![CDATA[Int J Gynaecol Obstet]]></source>
<year>2009</year>
<volume>105</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>3-4</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Incidence of cancer in 161 families affected by ataxia-telangiectasia University of North Carolina]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Swift]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Morrell]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Massey]]></surname>
<given-names><![CDATA[RB]]></given-names>
</name>
<name>
<surname><![CDATA[Chase]]></surname>
<given-names><![CDATA[CL]]></given-names>
</name>
</person-group>
<source><![CDATA[The New England Journal of Medicine]]></source>
<year>1991</year>
<volume>325</volume>
<page-range>1831-6</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Betamethasone and Improvement of Neurological Symptoms in Ataxia-Telangiectasia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Buoni]]></surname>
<given-names><![CDATA[Sabrina]]></given-names>
</name>
<name>
<surname><![CDATA[Zannolli]]></surname>
<given-names><![CDATA[Raffaella]]></given-names>
</name>
<name>
<surname><![CDATA[Sorrentino]]></surname>
<given-names><![CDATA[Livio]]></given-names>
</name>
<name>
<surname><![CDATA[Fois]]></surname>
<given-names><![CDATA[Alberto]]></given-names>
</name>
</person-group>
<source><![CDATA[Arch Neurol]]></source>
<year>2006</year>
<volume>63</volume>
<page-range>1480</page-range><publisher-loc><![CDATA[Italia ]]></publisher-loc>
<publisher-name><![CDATA[University of Siena]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The autosomal recessive cerebellar ataxias Universidad Pierre et Marie Curie Paris]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Anheim]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Tranchant]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Koenig]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[The New England Journal of Medicine]]></source>
<year>2012</year>
<volume>366</volume>
<page-range>636-46</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gatti]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Pagon]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Bird]]></surname>
<given-names><![CDATA[TD]]></given-names>
</name>
<name>
<surname><![CDATA[Dolan]]></surname>
<given-names><![CDATA[CR]]></given-names>
</name>
<name>
<surname><![CDATA[Stephens]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Adam]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
</person-group>
<source><![CDATA[Ataxia-Telangiectasia]]></source>
<year></year>
<publisher-loc><![CDATA[California ]]></publisher-loc>
<publisher-name><![CDATA[Department of Pathology. School of Medicine. UCLA]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ataxia-telangiectasia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dunn]]></surname>
<given-names><![CDATA[HG]]></given-names>
</name>
<name>
<surname><![CDATA[Meuwisssen]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Livingstone]]></surname>
<given-names><![CDATA[CS]]></given-names>
</name>
<name>
<surname><![CDATA[Pump]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[Can Med Assoc J]]></source>
<year>1964</year>
<volume>91</volume>
<page-range>1106-18</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ataxia-telangiectasia with ovarian gonadoblastoma and contralateral dysgerminoma]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goldsmith]]></surname>
<given-names><![CDATA[CI]]></given-names>
</name>
<name>
<surname><![CDATA[Hart]]></surname>
<given-names><![CDATA[WR]]></given-names>
</name>
</person-group>
<source><![CDATA[Cancer]]></source>
<year>1975</year>
<volume>36</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1838-42</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Gonadoblastoma and dysgerminoma with ataxia-telangiectasia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Buyse]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hartmen]]></surname>
<given-names><![CDATA[CT]]></given-names>
</name>
<name>
<surname><![CDATA[Wilson]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
</person-group>
<source><![CDATA[Birth Defects Orig Artic Ser]]></source>
<year>1976</year>
<volume>12</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>165-9</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ataxia - telangiectasia with dysgermi-noma of right ovary, papillary carcinoma of thyroid, and adenocarcinoma of pancreas]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Narita]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Takagi]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[Cancer]]></source>
<year>1984</year>
<volume>54</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1113-6</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ataxia-telangiectasia and endodermal sinus tumor of the ovary report of a case. Gynecologic]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pecorelli]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sartori]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Oncology]]></source>
<year>1998</year>
<volume>29</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>240-4</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[An unusual case of urinary incontinence, ataxia-telangiectasia, and metastatic dysgerminoma: case report and review of the literature]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[DeVries]]></surname>
<given-names><![CDATA[CR]]></given-names>
</name>
<name>
<surname><![CDATA[Kaplan]]></surname>
<given-names><![CDATA[GW.]]></given-names>
</name>
</person-group>
<source><![CDATA[Urology]]></source>
<year>1997</year>
<volume>50</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>453-5</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Reisli Dysgerminoma in a child with ataxia- telangiectasia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koksal]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Caliskan]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Ucar]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Yurtcu]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Artac]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Ilerisoy-Yakut]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<source><![CDATA[Pediatr Hematol Oncol]]></source>
<year>2007</year>
<volume>24</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>431-6</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pizzo]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Poplack]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<source><![CDATA[Principles and Practice of Pediatric Oncology]]></source>
<year>2010</year>
<edition>6</edition>
<page-range>1045-67</page-range><publisher-loc><![CDATA[EU ]]></publisher-loc>
<publisher-name><![CDATA[Wolters Kluwers]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
