<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0185-3325</journal-id>
<journal-title><![CDATA[Salud mental]]></journal-title>
<abbrev-journal-title><![CDATA[Salud Ment]]></abbrev-journal-title>
<issn>0185-3325</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0185-33252016000600311</article-id>
<article-id pub-id-type="doi">10.17711/SM.0185-3325.2016.036</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Las enzimas involucradas en el metabolismo de la cocaína: Una nueva aproximación farmacológica para el tratamiento de la intoxicación por sobredosis de cocaína]]></article-title>
<article-title xml:lang="en"><![CDATA[The enzymes involved in the metabolism of cocaine: A new pharmacological approach for the treatment of cocaine overdose toxicity]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salazar-Juárez]]></surname>
<given-names><![CDATA[Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barbosa-Méndez]]></surname>
<given-names><![CDATA[Susana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jurado]]></surname>
<given-names><![CDATA[Noe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Antón]]></surname>
<given-names><![CDATA[Benito]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Subdirección de Investigaciones Clínicas ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>39</volume>
<numero>6</numero>
<fpage>311</fpage>
<lpage>320</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0185-33252016000600311&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0185-33252016000600311&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0185-33252016000600311&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción: Se han desarrollado nuevas estrategias terapéuticas contra la toxicidad por sobredosis de cocaína basadas en el aumento en la actividad catalítica de enzimas que participan en la destrucción de su molécula, antes de que tenga la oportunidad de penetrar el tejido nervioso.  Objetivo: Describir los avances en el efecto del aumento en la actividad catalítica de las enzimas BChE y las hCE, producidas para el tratamiento de pacientes en condiciones de toxicidad por sobredosis de cocaína, así como mencionar sus ventajas y desventajas y su potencial uso futuro en pacientes internados por una sobredosis de cocaína.  Método: Se realizó una búsqueda bibliográfica por medio del PubMed, usando como descriptores las palabras "Cocaine", "hydrolase", "esterase" y "butyrylcholinesterase". Se obtuvieron 220 artículos de los cuales se usaron 126 para esta revisión.  Resultados: Las enzimas BChE, COCH y CoCe bacteriana disminuyeron significativamente los niveles de cocaína en la sangre y el cerebro y con ello atenuaron los efectos de una sobredosis de cocaína.  Discusión y conclusión: Los resultados obtenidos en modelos animales sugieren el potencial terapéutico del uso de estas enzimas en humanos, para inactivar rápidamente a la cocaína y desarrollar tratamientos para evitar las muertes asociadas con la intoxicación por sobredosis. Estas metodologías enzimáticas ofrecen una aplicación terapéutica novedosa para el tratamiento de la sobredosis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction: New therapeutic strategies against cocaine overdose toxicity have been developed. These new approaches are based on the design and synthesis of proteins involved in the destruction of cocaine before it has a chance to penetrate nerve tissue.  Objective: To review the progress in the effect of the increase in the catalytic activity of BChE and hCE enzymes produced for the treatment of patients in cocaine overdose toxicity conditions in order to determine the advantages and disadvantages of its use. Its potential future use in patients channeled by a cocaine overdose is also explored.  Method: A bibliographic search was conducted using PubMed; descriptors were "cocaine", "hydrolase", "esterase" and "butyrylcholinesterase". 220 papers were obtained and 126 papers were used for these review.  Results: The BChE, COCH and Coce bacterial enzymes significantly decrease the levels of cocaine in blood and brain and thereby attenuate the effects of a cocaine overdose.  Discussion and conclusion: The results obtained in animal models suggest the potential therapeutic use of these enzymes in humans to rapidly inactivate cocaine and develop treatments to stop deaths associated with cocaine overdose intoxication. These enzymatic approaches offer a novel therapeutic application to treat cocaine overdose.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Adicciones]]></kwd>
<kwd lng="es"><![CDATA[cocaína]]></kwd>
<kwd lng="es"><![CDATA[enzimas]]></kwd>
<kwd lng="es"><![CDATA[terapia farmacológica]]></kwd>
<kwd lng="en"><![CDATA[Addiction]]></kwd>
<kwd lng="en"><![CDATA[cocaine]]></kwd>
<kwd lng="en"><![CDATA[enzymes and pharmacotherapy]]></kwd>
</kwd-group>
</article-meta>
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<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[J Clin Psychopharmacol]]></source>
<year>2015</year>
<volume>35</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>396-405</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
