<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0185-3252</journal-id>
<journal-title><![CDATA[Anales médicos (México, Ciudad de México)]]></journal-title>
<abbrev-journal-title><![CDATA[An. méd.]]></abbrev-journal-title>
<issn>0185-3252</issn>
<publisher>
<publisher-name><![CDATA[Asociación Médica del Centro Médico ABC]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0185-32522026000200005</article-id>
<article-id pub-id-type="doi">10.24875/amh.25000041</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Relación entre los valores de Ct en RT-PCR y la presentación clínica de pacientes con COVID-19]]></article-title>
<article-title xml:lang="en"><![CDATA[Relation between Ct values in RT-PCR and clinical presentation of COVID-19 patients]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-Garza]]></surname>
<given-names><![CDATA[Luis E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barrera-Saldaña]]></surname>
<given-names><![CDATA[Hugo A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Hospital General de Zona con Medicina Familia No. 2 ]]></institution>
<addr-line><![CDATA[Nuevo León ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Secretaría de Ciencia, Humanidades, Tecnología e Innovación Laboratorio Nacional de Servicios Especializados de Investigación, Desarrollo e Innovación ]]></institution>
<addr-line><![CDATA[Nuevo León ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2026</year>
</pub-date>
<volume>71</volume>
<numero>2</numero>
<fpage>124</fpage>
<lpage>130</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0185-32522026000200005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0185-32522026000200005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0185-32522026000200005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: La utilidad de informar los valores del umbral de ciclos (Ct) en las pruebas de COVID-19 sigue siendo debatible.  Objetivo: Investigar la relación entre la carga viral y la clínica de COVID-19.  Material y métodos: Estudio observacional retrospectivo de pacientes con COVID-19 cuyas muestras se procesaron con un kit dirigido a genes N y E. El valor de Ct &lt; 40 se consideró positivo.  Resultados: Resultaron positivos 657, con edad media de 36 años y predominio masculino (72.6%). El 60.1% presentaron síntomas y los más prevalentes fueron cefalea (68.6%), tos (58%), mialgias (45.6%) y fiebre (44.3%). Los asintomáticos presentaron mayores valores de Ct para ambos genes, en comparación con los sintomáticos. En los sintomáticos, los valores de Ct para el gen N fueron más bajos en aquellos con cefalea, tos y fiebre, mientras que fueron más altos en aquellos con anosmia o ageusia. Se observaron patrones similares con el gen E.  Conclusiones: Los valores elevados de Ct se asociaron con pacientes asintomáticos, mientras que los valores bajos (altas cargas virales) se correlacionaron con la presencia de fiebre. Estos datos sugieren que el informe sistemático de los valores de Ct puede ser un indicador útil de la gravedad clínica inicial.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: The utility of reporting cycle threshold (Ct) values in COVID-19 testing remains debatable.  Objective: To investigate the relationship between viral load and the clinical presentation of COVID-19.  Material and methods: An observational retrospective study of COVID-19 patients whose samples were processed with a kit targeting the N and E genes. A Ct value &lt; 40 was considered positive.  Results: 657 resulted positive, with a mean age of 36 years and a male predominance (72.6%). 60.1% presented with symptoms, the most prevalent were headache (68.6%), cough (58%), myalgia (45.6%), and fever (44.3%). Asymptomatic patients had higher Ct values for both genes than symptomatic patients. In symptomatic patients, Ct values for the N gene were lower in those with headache, cough, and fever, but higher in those with anosmia/ageusia. Similar patterns were observed with the E gene.  Conclusions: Elevated Ct values were associated with asymptomatic patients, whereas low values (high viral loads) correlated with the presence of fever. These data suggest that routine reporting of Ct values may serve as a useful indicator of initial clinical severity.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Valores del umbral de ciclos]]></kwd>
<kwd lng="es"><![CDATA[Síntomas de COVID-19]]></kwd>
<kwd lng="es"><![CDATA[Carga viral]]></kwd>
<kwd lng="es"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="en"><![CDATA[Ct values]]></kwd>
<kwd lng="en"><![CDATA[COVID-19 symptoms]]></kwd>
<kwd lng="en"><![CDATA[Viral load]]></kwd>
<kwd lng="en"><![CDATA[SARS-CoV-2]]></kwd>
</kwd-group>
</article-meta>
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