<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0036-3634</journal-id>
<journal-title><![CDATA[Salud Pública de México]]></journal-title>
<abbrev-journal-title><![CDATA[Salud pública Méx]]></abbrev-journal-title>
<issn>0036-3634</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Salud Pública]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0036-36342003000200009</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Contact with hospital syringes containing body fluids: implications for medical waste management regulation]]></article-title>
<article-title xml:lang="es"><![CDATA[Jeringas en contacto con sangre y fluidos corporales utilizadas en el hospital: implicaciones para el manejo de desechos hospitalarios]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Volkow]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jacquemin]]></surname>
<given-names><![CDATA[Bénédicte]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vilar-Compte]]></surname>
<given-names><![CDATA[Diana]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castillo]]></surname>
<given-names><![CDATA[José Ramón]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Instituto Nacional de Cancerología  ]]></institution>
<addr-line><![CDATA[México D.F.]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2003</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2003</year>
</pub-date>
<volume>45</volume>
<numero>2</numero>
<fpage>120</fpage>
<lpage>122</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0036-36342003000200009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0036-36342003000200009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0036-36342003000200009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[OBJECTIVE: To determine amount of syringes used in the hospital and extent of contact with blood and body fluids of these syringes. MATERIAL AND METHODS: Syringe use was surveyed at a tertiary care center for one week; syringes were classified into the following four categories according to use: a) contained blood; b) contained other body fluids (urine, gastric secretion, cerebrospinal fluid, wound drainage); c) used exclusively for drug dilution and application in plastic intravenous (IV) tubes, and d) for intramuscular (IM), subcutaneous (SC), or intradermic (ID) injections. RESULTS: A total of 7 157 plastic disposable syringes was used; 1 227 (17%) contained blood during use, 346 (4.8%), other body fluids, 5 257 (73%) were used exclusively for drug dilution and application in plastic IV lines, and 327 (4.5%) were utilized for IM, SC, or ID injections. An estimated 369 140 syringes used annually, or eight syringes per patient per in-hospital day. All syringes were disposed of as regulated medical waste, in observance of the law. CONCLUSIONS: There is an urgent need to review recommendations for medical waste management by both international agencies and local governments, based on scientific data and a cost-benefit analysis, to prevent resource waste and further environmental damage.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[OBJETIVO: Cuantificar el número de jeringas que se utilizan en el hospital y calcular cuántas de éstas entran en contacto con sangre o fluidos corporales. MATERIAL Y MÉTODOS: Se hizo una encuesta del uso de jeringas en un hospital de tercer nivel de atención durante toda una semana. Se clasificaron, de acuerdo con el uso que se les dio, en cuatro categorías: a) aspiración de sangre, b) otros fluidos corporales (orina, secreción gástrica, líquido cefalorraquídeo, drenaje de herida, etcétera), c) uso exclusivo para diluir medicamentos y administrarlos a través de tubos de terapia intravenosa, d) para aplicación de inyecciones intramusculares (IM), subcutáneas (SC) o intradérmicas (ID). RESULTADOS: Se utilizó un total de 7 157 jeringas plásticas desechables, 1 227 (17%) de las cuales contuvieron sangre durante su uso, 346 (4.8%) otros líquidos corporales, 5 257 (73%) se usaron exclusivamente para diluir medicamentos y administrarlos mediante tubos de terapia intravenosa, y 327 (4.5%) se usaron para inyecciones IM, SC o ID. El consumo anual de jeringas estimado fue de 369 140, o sea ocho jeringas por paciente por día de hospitalización. Todas las jeringas fueron desechadas como residuo peligroso biológico infeccioso (RPBI) de acuerdo con la Norma -087 Ecol 1995. CONCLUSIONES: Existe una necesidad urgente de revisar las recomendaciones para el manejo de la basura médica regulada, tanto por agencias internacionales como por los gobiernos locales, que deberán basarse en información científica y en un análisis de costo beneficio para evitar el dispendio de recursos y un mayor daño al medio ambiente.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[medical waste]]></kwd>
<kwd lng="en"><![CDATA[syringes]]></kwd>
<kwd lng="en"><![CDATA[waste management]]></kwd>
<kwd lng="en"><![CDATA[Mexico]]></kwd>
<kwd lng="es"><![CDATA[residuos de hospitales]]></kwd>
<kwd lng="es"><![CDATA[jeringas]]></kwd>
<kwd lng="es"><![CDATA[manejo de residuos]]></kwd>
<kwd lng="es"><![CDATA[México]]></kwd>
</kwd-group>
</article-meta>
</front><body><![CDATA[ <p align="right"><font face="Verdana" size="2"><b>ART&Iacute;CULO BREVE</b></font></p>       <p>&nbsp;</p>     <p><font face="verdana" size="4"><b>Contact with hospital syringes containing    body fluids. Implications for medical waste management regulation</b></font></p>     <p>&nbsp;</p>     <p><font face="verdana" size="3"><b>Jeringas en contacto con sangre y fluidos    corporales utilizadas en el hospital. Implicaciones para el manejo de desechos    hospitalarios.</b></font></p>     <p>&nbsp;</p>     <p>&nbsp;</p>     <p>      <p><b><font face="verdana" size="2">Patricia Volkow, MD<SUP>I</SUP>; B&eacute;n&eacute;dicte    Jacquemin, MD<SUP>I</SUP>; Diana Vilar-Compte,<SUP> </SUP>MD, MSc<SUP>I</SUP>;    Jos&eacute; Ram&oacute;n Castillo, MD.<SUP>I</SUP></font></b></p>     <p><font face="verdana" size="2"><SUP>I</SUP> Instituto Nacional de Cancerolog&iacute;a.    M&eacute;xico, D.F., M&eacute;xico.</font></p>     ]]></body>
<body><![CDATA[<p>&nbsp;</p>     <p>&nbsp;</p> <HR>     <p><font face="verdana" size="2"><b>ABSTRACT</b></font></p>     <p><font face="verdana" size="2"><B>OBJECTIVE:</B> To determine amount of syringes used in  the hospital and extent of contact with blood and body fluids  of these syringes.    <br>  <B>MATERIAL AND METHODS:</B> Syringe use  was surveyed at a tertiary care center for one week;  syringes were classified into the following four categories  according to use: a) contained blood; b) contained other body  fluids (urine, gastric secretion, cerebrospinal fluid, wound  drainage); c) used exclusively for drug dilution and application in  plastic intravenous (IV) tubes, and d) for intramuscular  (IM), subcutaneous (SC), or intradermic (ID) injections.    <br>  <B>RESULTS:</B> A total of 7 157 plastic disposable syringes was used; 1  227 (17%) contained blood during use, 346 (4.8%), other  body fluids, 5 257 (73%) were used exclusively for drug  dilution and application in plastic IV lines, and 327 (4.5%) were  utilized for IM, SC, or ID injections. An estimated 369 140  syringes used annually, or eight syringes per patient per  in-hospital day. All syringes were disposed of as regulated medical  waste, in observance of the law.    <br>   <B>CONCLUSIONS:</B> There is an urgent need to review recommendations for medical    waste management by both international agencies and local governments, based    on scientific data and a cost-benefit analysis, to prevent resource waste and    further environmental damage. The English version of this paper is available    too at: <a href="http://www.insp.mx/salud/index.html">http://www.insp.mx/salud/index.html</a>    </font></p>     <p><font face="verdana" size="2"><b>Key words:</b> medical waste; syringes; waste    management; Mexico</font></p>  <hr>     <p><font face="verdana" size="2"><b>RESUMEN</b></font></p>     <p><font face="verdana" size="2"><B>OBJETIVO:</B> Cuantificar el n&uacute;mero de jeringas que se  utilizan en el hospital y calcular cu&aacute;ntas de &eacute;stas entran en  contacto con sangre o fluidos corporales.    ]]></body>
<body><![CDATA[<br> <B>MATERIAL Y M&Eacute;TODOS:</B> Se hizo una encuesta del uso de jeringas en un hospital  de tercer nivel de atenci&oacute;n durante toda una semana. Se  clasificaron, de acuerdo con el uso que se les dio, en  cuatro categor&iacute;as: a) aspiraci&oacute;n de sangre, b) otros fluidos  corporales (orina, secreci&oacute;n g&aacute;strica, l&iacute;quido cefalorraqu&iacute;deo,  drenaje de herida, etc&eacute;tera), c) uso exclusivo para  diluir medicamentos y administrarlos a trav&eacute;s de tubos de  terapia intravenosa, d) para aplicaci&oacute;n de inyecciones  intramusculares (IM), subcut&aacute;neas (SC) o intrad&eacute;rmicas  (ID).    <br> <B>RESULTADOS:</B> Se utiliz&oacute; un total de 7 157 jeringas  pl&aacute;sticas desechables, 1 227 (17%) de las cuales contuvieron  sangre durante su uso, 346 (4.8%) otros l&iacute;quidos corporales, 5  257 (73%) se usaron exclusivamente para diluir  medicamentos y administrarlos mediante tubos de terapia intravenosa,  y 327 (4.5%) se usaron para inyecciones IM, SC o ID. El  consumo anual de jeringas estimado fue de 369 140, o sea  ocho jeringas por paciente por d&iacute;a de hospitalizaci&oacute;n. Todas  las jeringas fueron desechadas como residuo peligroso  biol&oacute;gico infeccioso (RPBI) de acuerdo con la Norma -087  Ecol 1995.    <br>   <B>CONCLUSIONES:</B> Existe una necesidad urgente de revisar las recomendaciones    para el manejo de la basura m&eacute;dica regulada, tanto por agencias internacionales    como por los gobiernos locales, que deber&aacute;n basarse en informaci&oacute;n    cient&iacute;fica y en un an&aacute;lisis de costo beneficio para evitar el    dispendio de recursos y un mayor da&ntilde;o al medio ambiente. El texto completo    en ingl&eacute;s de este art&iacute;culo tambi&eacute;n est&aacute; disponible    en: <a href="http://www.insp.mx/salud/index.html">http://www.insp.mx/salud/index.html</a>    </font></p>     <p><font face="verdana" size="2"><b>Palabras clave:</b>residuos de hospitales;    jeringas; manejo de residuos; M&eacute;xico</font></p> <HR>     <p>&nbsp;</p>     <p>&nbsp;</p>     <p><font face="verdana" size="2">Establishing of special policies    for handling hospital solid waste has become a burden for health budgets in many countries. International    recommendations extended by World Health Organization (WHO) experts are based    on colloquial data rather than on scientific evidence.<SUP>1</SUP> Apparently,    the aim of these recommendations is to prevent blood-borne diseases, although    the potential risk of infection by accidental injury outside the hospital setting    is minimal.<SUP>2,3</SUP> In several countries these recommendations have resulted    in initiatives to regulate hospital waste management. However, legislation increases    the costs of hospital waste handling and results in unjustified spending of    health budgets in developing countries.<SUP>4,5</SUP> In addition, the environmental    impact of these recommendations has not been assessed.</font> </p>      <p><font face="verdana" size="2"> Few studies have described the characteristics    of hospital waste and practically no studies have assessed to what extent hospital    solid waste is contaminated with blood or other body fluids. The objective of    this study was to assess the number of syringes that contained blood or body    fluids, or those used exclusively for drugs dilution (DD) and application in    plastic intravenous tubes (PIVT).</font></p>     <p>&nbsp;</p>     <p><font face="verdana" size="3"><b>Material and Methods </b></font></p>     ]]></body>
<body><![CDATA[<p><font face="verdana" size="2">A survey was conducted during week, from July    13 to July 19, 1998, at a tertiary level of care 143-bed oncology center. A    questionnaire was applied daily to every nurse, physician, or paramedic on all    shifts, in all wards where syringes were used and collected at the end of each    shift. Syringes were classified and counted according to capacity, i.e., 1 ml,    5 ml, 10 ml, and 20 ml. They were also classified according to use: A) taking    blood samples, B) taking samples of other body fluids, C) used exclusively for    DD and application in PIVL, and D) for intramuscular (IM), subcutaneous (SC),    or intradermal (ID) injection.</font></p>     <p>&nbsp;</p>     <p><font face="verdana" size="3"><b>Results </b></font></p>     <p><font face="verdana" size="2">A total of 7 157 syringes were used during the    week surveyed as follows: 1 227 (17.4%) contained blood during use; 346 (4.8%)    contained other fluids (urine, gastric secretion, wound drainage); 5 257(73.4%)    were used exclusively for DD and application in PIVL, and 327(4.5%) were used    for IM, SC, or ID injections (<a href="#tab1">Table I</a>). The use of syringes    according to capacity was 6.86% for 1 ml, 38.8% for 5 ml, 36% for 10 ml, and    18.3% for 20 ml.</font></p>     <p><a name="tab1"></a></p>     <p>&nbsp;</p>     <p align="center"><img src="/img/revistas/spm/v45n2/a09t01.gif"></p>     <p>&nbsp;</p>     <p><font face="verdana" size="2"> An annual use of 369 140 syringes at the hospital    was estimated, eight syringes per patient in-hospital day. The weight of empty    syringes per year would be 3 733 kg; 2 725 kg of which would never have contact    with blood or any human tissue. The latter, plus the annual consumption of 1    479 kg of 28 104 plastic lines for infusion therapy, would add up to 4 204 kg    of waste with no infection potential at this hospital.</font></p>     <p>&nbsp;</p>      ]]></body>
<body><![CDATA[<p><b><font face="verdana" size="3">Discussion</font></b></p>     <p><font face="verdana" size="2">From the beginning of the AIDS epidemic, the    culture of disposable items has been fostered, to provide the public with the    feeling of absolute safety, notwithstanding the fact that many items are currently    sterilized in all surgery rooms in all countries with very high standards of    safety. The culture of disposable item utilization has increased waste production,    consumption of non-renewable resources, and damage to the environment. An adequate    program of sterilization and knowledge of the type of waste produced at the    hospital can help create a reasonable use of disposable items, and restore previous    practices such as use of glass syringes for DD and application in PIVT. Preventing    irreversible damage to the environment requires the development of a policy    to reduce waste production, reuse material, and recycle hospital appliances.<SUP>6</SUP></font></p>     <p><font face="verdana" size="2">The average cost of medical waste handling  in Mexico is $1.00 US dollars (USD) per kilogram.  Excessive costs of waste management in countries  that over-regulate medical waste management  - based  more on political issues than on scientific data -  is  draining health budgets, which are particularly meager in  developing countries.<SUP>4,7</SUP> Hospital epidemiologists  can contribute a great deal to saving money and  protecting the environment by rationalizing medical  waste management and the use of disposable  items.<SUP>8,9</SUP> </font></p>     <p><font face="verdana" size="2"> Furthermore, it has been proposed that the introduction  of plastic disposable syringes played a major role in altering the ecological  balance of routes for blood-borne pathogens in low- and middle-income countries.<SUP>10</SUP>  Plastic disposable syringes meant for one use are reused without proper sterilization  only in high-deprivation settings such as Africa and Latin America. Use of glass  syringes, which may be adequate for proper resterilization, has been proposed  as a way for preventing nosocomial HIV transmission and other blood-borne pathogens<SUP>11</SUP>  in middle- and low-income countries.</font></p>     <p><font face="verdana" size="2">There is an urgent need to revise the recommendations    for medical waste management by both international agencies and local governments,    based on scientific data and a cost-benefit analysis. The use of disposable    syringes in hospital settings should be rationalized; using properly sterilized    glass syringes would save resources and prevent further environmental damage.</font></p>     <p>&nbsp;</p>     <p><font face="verdana" size="3"><b>References</b></font></p>     <!-- ref --><p><font face="verdana" size="2">1. Coad A. Managing medical waste in developing countries. World  Health Organization, Ginebra, 1992. WHO/PEP/RUD/94.1. World Health  Organization, 1994. /PEP/RUD/94.1.</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=9167817&pid=S0036-3634200300020000900001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p><font face="verdana" size="2">2. Resnick L, Veren K, Salahuddin SZ, Tondreau S, Markham PD.  Stability and inactivation of HTLV III/LAV under clinical and laboratory  environments. JAMA 1986;255:1887-1891.</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=9167818&pid=S0036-3634200300020000900002&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p><font face="verdana" size="2">3. Henderson DK. Risk for occupational transmission of HIV-1  associated with clinical exposure. Ann Intern Med 1990;113:740-746.</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=9167819&pid=S0036-3634200300020000900003&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p><font face="verdana" size="2">4. Volkow P, Rangel-Frausto S, Ponce de Le&oacute;n-Rosales S. Basura  hospitalaria: comentarios sobre sus riesgos y su regulaci&oacute;n. Enferm Infecc  Microbiol Clin 1999;19:1-4.</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=9167820&pid=S0036-3634200300020000900004&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p><font face="verdana" size="2">5. Rutala WC, Mayhall G. The Society for Hospital Epidemiology of  America; medical waste. Infect Control Hosp Epidemiol  1991;12:38-48.</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=9167821&pid=S0036-3634200300020000900005&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p><font face="verdana" size="2">6. McVeigh P. OR nursing and environmental ethics. Medical waste  reduction, reuse and recycling. Today's OR Nurse 1993;15:13-18.</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=9167822&pid=S0036-3634200300020000900006&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p><font face="verdana" size="2">7. Rutala WA, Weber DJ. Infectious waste. N Engl J Med  1991;325: 578-582.</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=9167823&pid=S0036-3634200300020000900007&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p><font face="verdana" size="2">8. Daschner F. The hospital and pollution: Role of the hospital  epidemiologist in protecting the environment. En: Wenzel R, ed. Prevention and  control of nosocomial infection. 3rd ed. Baltimore, (MD) William &amp;  Wilkins; 1997:595-605.</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=9167824&pid=S0036-3634200300020000900008&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p><font face="verdana" size="2">9. Decker MD, Schaffer W. The relationship between the hospital and  the community. En: Bennett JV, Brachman JV, ed. Hospital infection.  4<SUP>th</SUP> ed. Philadelphia (PA): Lippincott-Raven Press, 1998;181-188.</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=9167825&pid=S0036-3634200300020000900009&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p><font face="verdana" size="2">10. Drucker E, Alcabes PG, Marx PA. The injection century: Massive  unsterile injections and the emergence of human pathogens.  Lancet 2001;358:1989-1992.</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=9167826&pid=S0036-3634200300020000900010&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p><font face="verdana" size="2">11. Petithory JC, De Loye J, Guesnu M, Parienne    P, Milgram M, Tardy M et al. Prevention de la transmission par les seringues    et aiguilles de VIH en France et en Afrique. Bull Acad Natl Med 1989;173:415-420.</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=9167827&pid=S0036-3634200300020000900011&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><p>&nbsp;</p>     <p>&nbsp;</p>     ]]></body>
<body><![CDATA[<p><font face="verdana" size="2"><b>Address reprint requests to</b>    <br>   Patricia Volkow    <br>   Instituto Nacional de Cancerolog&iacute;a    <br>   Avenida San Fernando 22, colonia Tlalpan    <br>   14000 M&eacute;xico, D.F., M&eacute;xico    <br>   E-mail: <a href="mailto:volkow@infosel.net.mx">volkow@infosel.net.mx</a></font></p>     <p><font face="verdana" size="2"><b>Received on:</b> September 26, 2001 <b>Accepted    on:</b> October 15, 2002</font> </p>     <p><font face="verdana" size="2">The English version of this paper is available    too at: <a href="http://www.insp.mx/salud/index.html">http://www.insp.mx/salud/index.html</a>    <br>   El texto completo en ingl&eacute;s de este art&iacute;culo tambi&eacute;n est&aacute;    disponible en: <a href="http://www.insp.mx/salud/index.html">http://www.insp.mx/salud/index.html</a>    </font></p>      ]]></body><back>
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