<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0035-0052</journal-id>
<journal-title><![CDATA[Revista mexicana de pediatría]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. pediatr.]]></abbrev-journal-title>
<issn>0035-0052</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Pediatría A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0035-00522022000100032</article-id>
<article-id pub-id-type="doi">10.35366/106858</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Pubertad precoz periférica por transferencia interpersonal de testosterona]]></article-title>
<article-title xml:lang="en"><![CDATA[Precocius puberty secundary to interpersonal transference of testosterone]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ayuzo-del Valle]]></surname>
<given-names><![CDATA[Cipatli]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores Caloca]]></surname>
<given-names><![CDATA[Oscar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Saavedra Castillo]]></surname>
<given-names><![CDATA[Eloisa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ayuzo]]></surname>
<given-names><![CDATA[Brenda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gallaga]]></surname>
<given-names><![CDATA[Juan Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Tecnológico y de Estudios Superiores de Monterrey Academia Mexicana de Pediatría ]]></institution>
<addr-line><![CDATA[Monterrey Nuevo León (NL)]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Zambrano Hellion Departamento de Pediatría ]]></institution>
<addr-line><![CDATA[San Pedro Garza García NL]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Mexicano del Seguro Social (IMSS) Unidad Médica de Alta Especialidad No. 25 ]]></institution>
<addr-line><![CDATA[Monterrey NL]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Autónoma de Guadalajara  ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2022</year>
</pub-date>
<volume>89</volume>
<numero>1</numero>
<fpage>32</fpage>
<lpage>35</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0035-00522022000100032&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0035-00522022000100032&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0035-00522022000100032&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  La pubertad precoz (PP) se caracteriza por el desarrollo de caracteres sexuales secundarios de manera prematura. Existen diferentes causas de PP. El objetivo de este artículo es describir cómo la exposición inadvertida de testosterona puede ocasionar PP periférica.  Caso clínico:  Preescolar masculino de cinco años, quien acude a consulta por presentar macrogenitosomía, así como aumento en la velocidad de crecimiento (20 cm/año). Exploración física: estatura de 135 cm (percentil 80), acné facial y aumento del desarrollo muscular; en genitales, pubarca grado II, longitud del pene de 12 cm (Tanner 5), testículos de 4 cm3 (Tanner 2). Edad ósea de 8.5 años. En estudios de laboratorio destacó que los niveles séricos de testosterona se encontraban en 98 ng/dL (normal &lt; 5 ng/dL). En interrogatorio dirigido, el padre refiere uso de gel que contiene testosterona para fines estéticos y contacto estrecho con sus hijos. Con toda esta información se concluyó PP periférica. Se suspendió el uso del gel, observando disminución de testosterona a 60 ng/dL a los 10 días.  Conclusión:  Cuando los padres utilizan productos con testosterona de manera tópica pueden ocasionar PP periférica en niños, la cual es una condición que se caracteriza por virilización, con crecimiento de genitales externos y aceleración de la maduración esquelética.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  Precocious puberty (PP) is characterized by the development of secondary sexual characteristics prematurely. There are different causes of PP. The objective of this article is to describe how inadvertent testosterone exposure can cause peripheral PP.  Clinical case:  Five-year-old male with macrogenitosomia and increased growth rate (20 cm/year). Physical examination: height 135 cm (80th percentile), facial acne, and increased muscle development; in genitalia, pubarche grade II, penis length 12 cm (Tanner 5), testicles 4 cm3 (Tanner 2). Bone age of 8.5 years. In laboratory studies, it was highlighted that serum testosterone levels were 98 ng/dL (normal &lt; 5 ng/dL). In directed questioning, the father refers to the use of gel containing testosterone for aesthetic purposes, and close contact with his children. With all this information, diagnosis of peripheral PP was concluded. The gel was suspended, observing a decrease in testosterone to 60 ng/dL at 10 days.  Conclusion:  Testosterone-containing products used topically by parents can cause peripheral PP in children, which is characterized by virilization, with growth of external genitalia and accelerated skeletal maturation.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[pubertad precoz]]></kwd>
<kwd lng="es"><![CDATA[testosterona]]></kwd>
<kwd lng="es"><![CDATA[aplicación tópica]]></kwd>
<kwd lng="es"><![CDATA[escolar]]></kwd>
<kwd lng="es"><![CDATA[varón]]></kwd>
<kwd lng="en"><![CDATA[precocious puberty]]></kwd>
<kwd lng="en"><![CDATA[testosterone]]></kwd>
<kwd lng="en"><![CDATA[topical application]]></kwd>
<kwd lng="en"><![CDATA[children]]></kwd>
<kwd lng="en"><![CDATA[male]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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