Optical spectroscopy and multivariate analysis of biomedical optics
J.L. Pichardo–Molinaª, C. Araujo–Andradeª and G. Gutiérrez–Juárezb
ª Centro de Investigaciones en Óptica, A.C., Loma del Bosque No. 115, Col. Lomas del Campestre, 37150, León, Gto. México.
b Instituto de Física de la Universidad de Guanajuato, Apartado Postal E–143, 37150 León, Gto. México.
Recibido el 9 de mayo de 2007 ]]> Aceptado el 5 de marzo de 2008
Abstract
Although some optical spectroscopy methods were introduced more than ten decades ago, they are still finding new applications in many areas of science. Specifically, medicine and biology are two areas of research where optical methods may facilitate and improve the study and characterization of tissue and biological molecules in order to improve medical diagnosis. Optical spectroscopy can aid in the study and detection of some diseases faster than standard laboratory techniques. This work demonstrates applications of Micro–Raman spectroscopy and multivariate analysis to biomedical problems such as: breast cancer detection, toxoplasmosis study through indirect antibody detection, and discrimination between antibody isotypes (IgG and IgM).
Keywords: Colostrum; multivariate; NIR; Raman; serum.
Resumen
Algunas espectroscopias ópticas existen desde hace más de diez décadas; sin embargo, en recientes años estas técnicas se han aplicado en distintas areas del conocimiento. Por otro lado, la medicina y la biología son dos areas de investigación donde la óptica puede facilitar el estudio y caracterización de tejidos y moléculas biológicas con el fin de mejorar el diagnóstico clínico. Las espectroscopias ópticas pueden ayudar en el estudio y deteccion de algunas enfermedades de manera mas rápida que las técnicas estándar de laboratorio. En este trabajo, mostramos algunas aplicaciones de la espectroscopia Raman y del análisis multivariante en algunos problemas específicos del área biomédica, por ejemplo: detección de cáncer de mama, diagnóstico de la toxoplasmosis e identificación de isotipos (IgG e IgM).
Descriptores: Calostro; multivariado; NIR; Raman; suero.
]]> PACS: 87.64.Je; 89.20.–a; 87.14.–g
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Acknowledgements
The authors wish to thank the Consejo Nacional de Ciencia y Tecnología (CONACYT) and the Consejo Nacional de Ciencia y Tecnología de Guanajuato (CONCyTEG) for financial support under Grant No. 54467 and Anexo 07–04–K662–80A01.
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