<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0028-3746</journal-id>
<journal-title><![CDATA[Neumología y cirugía de tórax]]></journal-title>
<abbrev-journal-title><![CDATA[Neumol. cir. torax]]></abbrev-journal-title>
<issn>0028-3746</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Neumología y Cirugía de Tórax; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas; Sociedad Cubana de Neumología; Sociedad Paraguaya de Neumología; Sociedad Boliviana de Neumología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0028-37462018000400247</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Patrones de farmacorresistencia en población migrante con tuberculosis pulmonar]]></article-title>
<article-title xml:lang="en"><![CDATA[Drug resistance patterns in migrant population with pulmonary tuberculosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orozco-Andrade]]></surname>
<given-names><![CDATA[Isaías]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Acosta-Loya]]></surname>
<given-names><![CDATA[Jesús Aníbal]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bravo-Rodríguez]]></surname>
<given-names><![CDATA[Gregorio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Lozano]]></surname>
<given-names><![CDATA[Fabricio N]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Espinoza-Hernández]]></surname>
<given-names><![CDATA[Manuel E]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Enríquez-Porras]]></surname>
<given-names><![CDATA[Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Durán-Peña]]></surname>
<given-names><![CDATA[Omar A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orozco-Béjar]]></surname>
<given-names><![CDATA[Isaías A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro de Diagnóstico y Tratamiento Integral de la Tuberculosis Servicios Médicos de la Frontera ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Secretaría de Salud del Estado de Chihuahua  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma de Chihuahua  ]]></institution>
<addr-line><![CDATA[Chihuahua Chihuahua]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>77</volume>
<numero>4</numero>
<fpage>247</fpage>
<lpage>257</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0028-37462018000400247&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0028-37462018000400247&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0028-37462018000400247&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Objetivo:  Describir los patrones de farmacorresistencia en población migrante con tuberculosis pulmonar.  Material y métodos:  Revisamos las bases de datos de los casos de tuberculosis pulmonar confirmados con cultivo positivo.  Resultados:  De acuerdo con la evaluación médica y radiográfica de 394,482 solicitantes a emigrar a los Estados Unidos se detectaron 8,775 (2.2%) sospechosos, de los cuales 157 (1.8%) resultaron positivos para tuberculosis pulmonar. Veinticuatro pacientes no contaban con pruebas de sensibilidad y tres más tuvieron los cultivos negativos, por lo tanto, la investigación se llevó a cabo sólo con 130 casos. Sólo tres fueron multidrogorresistentes, 18 monorresistentes y cinco polirresistentes. El 52% fueron hombres. Los grupos de edad con mayor número de casos fueron los de 51 a 60 y 71 a 80 años.  Conclusiones:  La resistencia a los medicamentos antituberculosis es un obstáculo para un tratamiento efectivo. El manejo de casos se vuelve difícil y el desafío se ve agravado por costos económicos y sociales catastróficos. De ahí la necesidad de trabajar en la prevención de los factores que condicionan la resistencia; y, por otro lado, insistir que la industria farmacéutica debe crear nuevos y efectivos medicamentos antituberculosis, con menos efectos secundarios y a un menor costo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Objective:  To describe the drug resistance pattern of pulmonary tuberculosis in migrant population.  Material and methods:  The databases of pulmonary tuberculosis (PTB) cases confirmed with culture positive were reviewed.  Results:  According to the medical and radiographic evaluation of 394,482 applicants that were going to emigrate to the United States, 8,775 (2.2%) were patient with suspected TB, of which, 157 (1.8%) were positive for PTB. Twenty-four patients did not have evidence of drug sensitivity, and three more had negative cultures, therefore, the investigation was carried out with only 130 cases. Only three were multidrug-resistant, 18 mono-resistant and five poly-resistant. 52% were men. The age groups with the highest number of cases were those from 51 to 60 and 71 to 80 years.  Conclusions:  The resistance to anti-tuberculosis drugs is an obstacle to effectively treat TB. Case management becomes difficult and the challenge is compounded by catastrophic economic and social costs. Hence the need to work on the prevention of the factors conditioning drug resistance; and on the other hand, to insist that the pharmaceutical industry must create a new and effective anti-tuberculosis drugs with fewer side effects and at a lower cost.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Tuberculosis pulmonar]]></kwd>
<kwd lng="es"><![CDATA[farmacorresistencia]]></kwd>
<kwd lng="es"><![CDATA[migrantes]]></kwd>
<kwd lng="en"><![CDATA[Pulmonary tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[drug resistance]]></kwd>
<kwd lng="en"><![CDATA[migrants]]></kwd>
</kwd-group>
</article-meta>
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