<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0028-3746</journal-id>
<journal-title><![CDATA[Neumología y cirugía de tórax]]></journal-title>
<abbrev-journal-title><![CDATA[Neumol. cir. torax]]></abbrev-journal-title>
<issn>0028-3746</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Neumología y Cirugía de Tórax; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas; Sociedad Cubana de Neumología; Sociedad Paraguaya de Neumología; Sociedad Boliviana de Neumología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0028-37462018000100019</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Intercambio gaseoso a 2,240 m de altura de acuerdo a modelos computacionales de pulmón]]></article-title>
<article-title xml:lang="en"><![CDATA[Gas exchange at 2,240 m above sea level from computational models of the lung]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Padilla]]></surname>
<given-names><![CDATA[José Rogelio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2018</year>
</pub-date>
<volume>77</volume>
<numero>1</numero>
<fpage>19</fpage>
<lpage>23</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0028-37462018000100019&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0028-37462018000100019&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0028-37462018000100019&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  El impacto de las principales variables pulmonares y extrapulmonares que afectan el intercambio gaseoso pulmonar fueron analizadas en modelos computacionales de pulmón a fines de los años sesenta. El objetivo del presente trabajo fue analizar de manera similar el intercambio gaseoso pero a una altura de 2,240 m sobre el nivel del mar y compararla con la encontrada a nivel del mar, al modificar las variables más relevantes.  Métodos:  Se utilizó el modelo de intercambio gaseoso utilizado por West, programada originalmente en el lenguaje Fortran.  Resultados:  Los patrones de respuesta a cambios en las típicas variables: gasto cardíaco, ventilación minuto, exceso de base, cortocircuito, desequilibrio V&#8217;/Q&#8217;, fracción inspirada de oxígeno, hemoglobina, p50, estimados para la Ciudad de México son en general paralelos a los estimados para el nivel del mar. Sin embargo, es más acertado utilizar las estimaciones específicas a la altitud que las que se suelen ofrecer en los libros de texto que proceden de modelos para nivel del mar.  Conclusión:  Los modelos de intercambio gaseoso permiten estimar el desempeño pulmonar bajo diferentes circunstancias controladas, pero es importante recalcar que en vivo, ocurren ajustes fisiológicos que no se consideran en los modelos por lo que hay que tomarlos con reserva y de preferencia buscar documentaciones empíricas de los hallazgos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract.  Introduction: The impact of the main pulmonary and extra-pulmonary variables affecting gas exchange was analyzed in the sixties in computer models of the lung. The objective was to analize similarly gas exchange but at 2,240 m of altitude (Mexico City) and compare it with that estimated for sea level.  Methods: We utilized West pulmonary gas exchange model, originally programmed in Fortran language.  Results: The pattern of response to changes in typical variables: cardiac output, alveolar ventilation, shunt, V&#8217;/Q&#8217; heterogeneity, inspired fraction of oxygen, hemoglobin, estimated for Mexico City are in general parallel to those found for sea level. However is more accurate to utilize specific estimations for the altitude than to those described usually in texbooks assuming sea level.  Conclusions:  Gas exchange models allow to predict lung performance under controlled situations, but it is important to clarify than in vivo, additional adjustments occur, often several at the same time, circumstances not considered in the models, and therefore results have to be taken with reserve, searching always for empirical documentation.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Intercambio gaseoso]]></kwd>
<kwd lng="es"><![CDATA[shunt]]></kwd>
<kwd lng="es"><![CDATA[índices de oxigenación]]></kwd>
<kwd lng="es"><![CDATA[altitud]]></kwd>
<kwd lng="en"><![CDATA[Gas exchange]]></kwd>
<kwd lng="en"><![CDATA[shunt]]></kwd>
<kwd lng="en"><![CDATA[oxygenation index]]></kwd>
<kwd lng="en"><![CDATA[altitude]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wagner]]></surname>
<given-names><![CDATA[PD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assessment of gas exchange in lung disease: balancing accuracy against feasibility]]></article-title>
<source><![CDATA[Crit Care]]></source>
<year>2007</year>
<volume>11</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>182</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[West]]></surname>
<given-names><![CDATA[JB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ventilation-perfusion inequality and overall gas exchange in computer models of the lung]]></article-title>
<source><![CDATA[Respir Physiol]]></source>
<year>1969</year>
<volume>7</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>88-110</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[West]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wagner]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pulmonary gas exchange]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[West]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Bioengineering aspects of the lung]]></source>
<year>1970</year>
<page-range>361-457</page-range><publisher-loc><![CDATA[New York ]]></publisher-loc>
<publisher-name><![CDATA[Marcel Dekker]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Siggaard-Andersen]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Siggaard-Andersen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The oxygen status algorithm: a computer program for calculating and displaying pH and blood gas data]]></article-title>
<source><![CDATA[Scand J Clin Lab Invest Suppl]]></source>
<year>1990</year>
<volume>203</volume>
<page-range>29-45</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Perez-Padilla]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[[Altitude, the ratio of PaO2 to fraction of inspired oxygen, and shunt: impact on the assessment of acute lung injury]]]></article-title>
<source><![CDATA[Arch Bronconeumol]]></source>
<year>2004</year>
<volume>40</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>459-62</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Perez-Padilla]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Torre-Bouscoulet]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Muiño]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Proyecto Latinoamericano de Investigacion en Obstruccion Pulmonar (PLATINO) group. Prevalence of oxygen desaturation and use of oxygen at home in adults at sea level and at moderate altitude]]></article-title>
<source><![CDATA[Eur Respir J]]></source>
<year>2006</year>
<volume>27</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>594-9</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Perez-Padilla]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Population distribution residing at different altitudes: Implications for hypoxemia]]></article-title>
<source><![CDATA[Arch Med Res]]></source>
<year>2002</year>
<volume>33</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>162-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Perez-Padilla]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Franco-Marina]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The impact of altitude on mortality from tuberculosis and pneumonia]]></article-title>
<source><![CDATA[Int J Tuberc Lung Dis]]></source>
<year>2004</year>
<volume>8</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1315-20</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Perez-Padilla]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Garcia-Sancho]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Franco-Marina]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Lopez-Gatell]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Bojorquez]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The impact of altitude on hospitalization and hospital mortality from pandemic 2009 influenza a (H1N1) virus pneumonia in Mexico]]></article-title>
<source><![CDATA[Salud Publica Mex]]></source>
<year>2013</year>
<volume>55</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>92-5</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
