<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422024000500042</article-id>
<article-id pub-id-type="doi">10.22201/fm.24484865e.2024.67.5.05</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Metástasis cerebral múltiple de adenocarcinoma pancreático. Reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Multiple Brain Metastases from Pancreatic Adenocarcinoma: A Case Report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alonso Bracho]]></surname>
<given-names><![CDATA[Sofía Aranxa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arroyo Zavala]]></surname>
<given-names><![CDATA[Octavio Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Laredo Gómez]]></surname>
<given-names><![CDATA[Jenner]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vázquez Nieves]]></surname>
<given-names><![CDATA[José Roberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Hospital Regional General Ignacio Zaragoza Departamento de Neurocirugía]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Hospital Regional General Ignacio Zaragoza ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2024</year>
</pub-date>
<volume>67</volume>
<numero>5</numero>
<fpage>42</fpage>
<lpage>49</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422024000500042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422024000500042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422024000500042&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  Las metástasis cerebrales son las lesiones malignas más comunes en el sistema nervioso central. Las metástasis cerebrales de cáncer pancreático son muy raras y con un pobre pronóstico. El objetivo del presente caso es describir una rara patología y el trabajo realizado para la atención del paciente.  Reporte de caso: Hombre de 49 años con cambios de la personalidad, depresión y apatía. Cinco días previos a su ingreso se agregó a sus síntomas disartria, hemiparesia izquierda y desorientación, que progresó a un mayor deterioro del estado de alerta y que ameritó un manejo avanzado de la vía aérea. La tomografía de cráneo evidenció lesiones cerebrales quísticas. Se realizó una craniectomía descompresiva, así como drenaje y resección de lesión de mayor tamaño. El estudio de inmunohistoquímica reportó CK 19 en tumor cerebral, compatible con adenocarcinoma pancreático.  Conclusiones: Se presentó un caso raro de metástasis cerebrales múltiples y sospecha de metástasis pulmonar, ambos secundarios a adenocarcinoma de páncreas primario. El paciente debutó con síntomas asociados a las lesiones cerebrales. La incidencia de metástasis cerebrales con un tumor primario pancreático es muy baja, y es un caso excepcional al debutar con síntomas neurológicos. La resección quirúrgica de la lesión cerebral tuvo un rol limitado en la mejoría clínica del paciente, ya que la progresión de la enfermedad fue rápida, pero útil para establecer la confirmación del diagnóstico mediante inmunohistoquímica. Al no contarse con pruebas de tamizaje para tumores pancreáticos, es difícil identificarlos en estadios tempranos y sin síntomas gastrointestinales presentes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Brain metastases are the most common malignant lesions in the central nervous system. Brain metastases from pancreatic cancer are very rare, with poor prognosis. The present paper aims to describe a rare pathology and the work carried out for the patient&amp;apos;s care.  Case report:  49-year-old man with personality changes, depression, and apathy. Five days before admission, he presented dysarthria, added left hemiparesis, and disorientation that progressed to sudden neurological deterioration that required advanced airway management. A computed tomography study was seen with cerebral cystic lesions. A decompressive craniectomy and drainage of the larger lesion was performed, with subsequent resection. The study protocol with immunohistochemistry reports CK 19, compatible with pancreatic adenocarcinoma.  Conclusions: A rare case of multiple brain metastases and suspected lung metastasis, both secondary to primary pancreatic adenocarcinoma was presented. The patient began with symptoms associated with brain lesions. The incidence of brain metastases with a primary pancreatic tumor is very low, and this is an exceptional case when presenting with neurological symptoms. Surgical resection of the brain lesion had a limited role in the clinical improvement of the patient since the progression of the disease was rapid. Still, it was useful to establish a diagnosis by immunohistochemistry. Since there are no screening tests for pancreatic tumors, it is difficult to identify them in early stages and without gastrointestinal symptoms.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Adenocarcinoma pancreático]]></kwd>
<kwd lng="es"><![CDATA[tumores cerebrales]]></kwd>
<kwd lng="es"><![CDATA[metástasis cerebral]]></kwd>
<kwd lng="es"><![CDATA[citoqueratina 19]]></kwd>
<kwd lng="es"><![CDATA[inmunohistoquímica]]></kwd>
<kwd lng="en"><![CDATA[Pancreatic adenocarcinoma]]></kwd>
<kwd lng="en"><![CDATA[brain tumors]]></kwd>
<kwd lng="en"><![CDATA[brain metastases]]></kwd>
<kwd lng="en"><![CDATA[cytokeratin 19]]></kwd>
<kwd lng="en"><![CDATA[immunohistochemistry]]></kwd>
</kwd-group>
</article-meta>
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