<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422021000600009</article-id>
<article-id pub-id-type="doi">10.22201/fm.24484865e.2021.64.6.02</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Autofagia en las células beta pancreáticas y su papel en la diabetes mellitus tipo 2]]></article-title>
<article-title xml:lang="en"><![CDATA[Autophagy in pancreatic beta cells and its role in type 2 diabetes mellitus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velázquez-Paniagua]]></surname>
<given-names><![CDATA[Mireya]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Sánchez]]></surname>
<given-names><![CDATA[Ignacio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Tamariz]]></surname>
<given-names><![CDATA[Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Peláez]]></surname>
<given-names><![CDATA[María Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ángeles-Aguilar]]></surname>
<given-names><![CDATA[Lorelei Larissa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ayala-Orta]]></surname>
<given-names><![CDATA[Sofía Ximena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[de Jesús-Javier]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coronel-Cruzc]]></surname>
<given-names><![CDATA[Cristina]]></given-names>
</name>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Química ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Nacional Autónoma de México  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>64</volume>
<numero>6</numero>
<fpage>9</fpage>
<lpage>25</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422021000600009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422021000600009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422021000600009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La autofagia es un mecanismo crucial para el funcionamiento y supervivencia de las células beta pancreáticas. Su desregulación se ha asociado a obesidad, resistencia a la insulina e intolerancia a la glucosa. Más aún, se ha reportado que la autofagia disminuida en las células beta secretoras de insulina contribuye al desarrollo de la diabetes mellitus tipo 2 (DMT2), la cual constituye alrededor del 95% de todos los casos de diabetes y es una enfermedad metabólica crónica que actualmente afecta a millones de personas en todo el mundo. En diferentes modelos de roedores ya sea diabéticos o con obesidad, se ha observado que el tratamiento con potenciadores de la autofagia disminuye los niveles de glucosa, incrementa la sensibilidad a la insulina y protege a las células beta de la apoptosis. De lo anterior, recientemente se ha propuesto realizar una intervención temprana en los pacientes con DMT2, utilizando fármacos que promuevan la autofagia, lo cual podría ayudar a preservar la masa de las células beta y prevenir la progresión de la enfermedad. Esta revisión provee un panorama general de la importancia del proceso fisiológico de la autofagia y su inminente participación en el desarrollo de la DMT2.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Autophagy is a crucial mechanism for the functioning and survival of pancreatic beta cells. Its dysregulation has been associated with obesity, insulin resistance, and glucose intolerance. Furthermore, decreased autophagy in insulin-secreting beta cells has been reported to contribute to the development of type 2 diabetes mellitus (T2DM), which constitutes about 95% of all diabetes cases and is a chronic metabolic disease that it currently affects millions of people around the world. In different models of rodents, whether diabetic or obese, it has been observed that treatment with autophagy enhancers lowers glucose levels, increases insulin sensitivity, and protects beta cells from apoptosis. As stated above, it has recently been proposed to carry out an early intervention in patients with T2DM, using drugs that promote autophagy, which could help preserve the mass of beta cells and prevent the progression of the disease. This review provides an overview of the importance of the physiological process of autophagy and its imminent role in the development of T2DM.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Células beta pancreáticas]]></kwd>
<kwd lng="es"><![CDATA[autofagia]]></kwd>
<kwd lng="es"><![CDATA[muerte celular]]></kwd>
<kwd lng="es"><![CDATA[diabetes mellitus tipo 2]]></kwd>
<kwd lng="en"><![CDATA[Pancreatic beta cells]]></kwd>
<kwd lng="en"><![CDATA[autophagy]]></kwd>
<kwd lng="en"><![CDATA[cell death]]></kwd>
<kwd lng="en"><![CDATA[diabetes mellitus type 2]]></kwd>
</kwd-group>
</article-meta>
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