<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422020000300028</article-id>
<article-id pub-id-type="doi">10.22201/fm.24484865e.2019.63.3.06</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Enfermedad pulmonar obstructiva crónica (EPOC). Bases para el médico general]]></article-title>
<article-title xml:lang="en"><![CDATA[Chronic Obstructive Pulmonary Disease (COPD). Bases for the General Practitioner]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Luna]]></surname>
<given-names><![CDATA[Monserrat]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas Granados]]></surname>
<given-names><![CDATA[Adelina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lázaro Pacheco]]></surname>
<given-names><![CDATA[Ricardo Isidro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meza Alvarado]]></surname>
<given-names><![CDATA[José Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ubaldo Reyes]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ángeles Castellanos]]></surname>
<given-names><![CDATA[Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,aff1  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Especialidades Médicas del Estado de Veracruz &#8220;Dr. Rafael Lucio&#8221; Servicio de Neumología ]]></institution>
<addr-line><![CDATA[Veracruz Ver.]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Cd. Mx. ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>63</volume>
<numero>3</numero>
<fpage>28</fpage>
<lpage>35</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422020000300028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422020000300028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422020000300028&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La enfermedad pulmonar obstructiva crónica (EPOC) es una enfermedad crónico-degenerativa frecuente, prevenible y tratable, caracterizada por persistentes síntomas respiratorios y limitación del flujo aéreo. En 2016, el Instituto Nacional de Enfermedades Respiratorias (INER) la ubicó en el cuarto lugar en la tabla de morbi-mortalidad anual en México. Su prevalencia está directamente relacionada con la del tabaquismo; sin embargo, su desarrollo es multifactorial. Para el estudio de la EPOC es importante conocer los antecedentes de exposición a factores de riesgo y la presencia de los principales síntomas; es esencial una historia clínica bien detallada, donde se recabe la mayor cantidad de datos de todo nuevo paciente en el que se conozca o se sospeche de la enfermedad, así como una espirometría para establecer el diagnóstico. Debido a la gran variabilidad que existe entre los pacientes con EPOC, es necesario establecer tratamiento farmacológico individualizado. Los fármacos utilizados en su tratamiento reducen los síntomas, la frecuencia y la gravedad de las exacerbaciones; sin embargo, no hay ningún medicamento que modifique el deterioro a largo plazo de la función pulmonar. Por lo tanto, el conocimiento básico de este padecimiento por el médico de primer contacto es esencial para la sospecha en una etapa inicial, y así ofrecer al paciente una intervención médica inmediata. El presente trabajo tiene la finalidad de acercar al médico general una visión básica de la EPOC.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Chronic obstructive pulmonary disease (COPD) is a chronic degenerative disease. It is a frequent, preventable and treatable disease characterized by persistent respiratory symptoms and airflow limitation. The National Institute of Respiratory Diseases (INER), ranked COPD in 2016 in fourth place in the table of annual morbidity and mortality in Mexico. The prevalence of COPD is directly related to smoking; however, its development is multifactorial. For its study it is important to know of any prior exposure to risk factors and of any manifestation of the main symptoms. To make a diagnosis, a detailed clinical history, where the largest amount of data is collected from every new possible COPD patient, and a spirometry are essential. Individual pharmacological treatment is necessary due to the great variability among COPD patients. The drugs used in the treatment of COPD reduce the symptoms, the frequency and severity of exacerbations; however, there is no medication that modifies the long-term deterioration of the lung function. Therefore, a basic knowledge of this condition by the medical doctor first contacted, is essential for the suspicion of COPD in its initial stage and thus, offer the patient immediate medical intervention. The objective of the present work is to provide a basic overview of COPD to the general practitioner.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Enfermedad pulmonar obstructiva crónica]]></kwd>
<kwd lng="es"><![CDATA[biomasa]]></kwd>
<kwd lng="es"><![CDATA[tabaco]]></kwd>
<kwd lng="es"><![CDATA[bronquitis obstructiva crónica]]></kwd>
<kwd lng="es"><![CDATA[enfisema]]></kwd>
<kwd lng="es"><![CDATA[aparato respiratorio]]></kwd>
<kwd lng="en"><![CDATA[Chronic obstructive pulmonary disease]]></kwd>
<kwd lng="en"><![CDATA[biomass]]></kwd>
<kwd lng="en"><![CDATA[tobacco]]></kwd>
<kwd lng="en"><![CDATA[chronic obstructive bronchitis]]></kwd>
<kwd lng="en"><![CDATA[emphysema]]></kwd>
<kwd lng="en"><![CDATA[respiratory system]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="">
<collab>Global Initiative for Chronic Obstructive Lung Disease</collab>
<source><![CDATA[Diagnosis, Management and Prevention of COPD 2018]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McDonald]]></surname>
<given-names><![CDATA[CF]]></given-names>
</name>
<name>
<surname><![CDATA[Khor]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Advances in chronic obstructive pulmonary disease]]></article-title>
<source><![CDATA[Intern Med J]]></source>
<year>2013</year>
<volume>43</volume>
<page-range>854-62</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Raherison]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Girodet]]></surname>
<given-names><![CDATA[PO]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Epidemiology of COPD]]></article-title>
<source><![CDATA[European Respiratory Review]]></source>
<year>2009</year>
<volume>18</volume>
<page-range>213-21</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Halbert]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Natoli]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Gano]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Badamgarav]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Buist]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[Mannino]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Global burden of COPD Systematic review and meta-analysis]]></article-title>
<source><![CDATA[European Respiratory Journal]]></source>
<year>2006</year>
<volume>28</volume>
<page-range>523-32</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Adeloye]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Chua]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Basquill]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Papana]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Theodoratou]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Global and regional estimates of COPD prevalence Systematic review and meta-analysis]]></article-title>
<source><![CDATA[J Glob Health]]></source>
<year>2015</year>
<volume>5</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>1-17</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Menezes]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Perez-Padilla]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Jardim]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Muiño]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Lopez]]></surname>
<given-names><![CDATA[MV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chronic Obstructive Pulmonary Disease in five Latin American cities (the PLATINO Study) a prevalence study]]></article-title>
<collab>Valdivia G et al</collab>
<source><![CDATA[The Lancet]]></source>
<year>2005</year>
<volume>26</volume>
<page-range>1875-81</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Laniado-Laborín]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Rendón]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bauerle]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chronic obstructive pulmonary disease case finding in Mexico in an at-risk population]]></article-title>
<source><![CDATA[International Journal of Tuberculosis and Lung Disease]]></source>
<year>2011</year>
<volume>15</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>818-23</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="">
<collab>Instituto Nacional de Enfermedades Respiratorias</collab>
<source><![CDATA[]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Salvi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tobacco smoking and environmental risk factors for chronic obstructive pulmonary disease]]></article-title>
<source><![CDATA[Clinics in Chest Medicine]]></source>
<year>2014</year>
<volume>35</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>17-27</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rovina]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Koutsoukou]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Koulouris]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inflammation and immune response in COPD: Where do we stand?]]></article-title>
<source><![CDATA[Mediators of Inflammation]]></source>
<year>2013</year>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rahaghi]]></surname>
<given-names><![CDATA[FF]]></given-names>
</name>
<name>
<surname><![CDATA[Miravitlles]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Long-term clinical outcomes following treatment with alpha 1-proteinase inhibitor for COPD associated with alpha-1 antitrypsin deficiency: A look at the evidence]]></article-title>
<source><![CDATA[Respiratory Research]]></source>
<year>2017</year>
<volume>30</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>105</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Salvi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Barnes]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Is exposure to biomass smoke the biggest risk factor for COPD globally]]></article-title>
<source><![CDATA[Chest]]></source>
<year>2010</year>
<volume>138</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>3-6</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Regalado]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Perez-Padilla]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Sansores]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Páramo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Braurer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Paré]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The effect of biomass Burning on Respiratory Symptoms and Lung Function in Rural Mexico Women]]></article-title>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2006</year>
<volume>15</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>901-5</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Romieu]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Riojas-Rodriguez]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Marrón]]></surname>
<given-names><![CDATA[AT]]></given-names>
</name>
<name>
<surname><![CDATA[Schilmann]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Perez-Padilla]]></surname>
</name>
<name>
<surname><![CDATA[Masera]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Improved Biomass Stove Intervention in Rural Mexico]]></article-title>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2009</year>
<volume>180</volume>
<page-range>649-56</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dutta]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Roychoudhury]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Chowdhury]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ray]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Changes in sputum cytology, airway inflammation and oxidative stress due to chronic inhalation of biomass smoke during cooking in premenopausal rural Indian women]]></article-title>
<source><![CDATA[Int J of Hygiene and Environmental Health]]></source>
<year>2013</year>
<volume>216</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>301-8</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Oyarzún]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Olloquequi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pathogenic Mechanisms in Chronic Obstructive Pulmonary Disease Due to Biomass Smoke Exposure]]></article-title>
<source><![CDATA[Arch Bronconeumol]]></source>
<year>2015</year>
<volume>51</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>285-92</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hansel]]></surname>
<given-names><![CDATA[NN]]></given-names>
</name>
<name>
<surname><![CDATA[McCormack]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Effects of Air Pollution and Temperature on COPD]]></article-title>
<source><![CDATA[Journal of Chronic Obstructive Pulmonary Disease]]></source>
<year>2016</year>
<volume>13</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>372-9</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kodgule]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Salvi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Exposure to Biomass Smoke as a Cause for Airway Disease in Women and Children]]></article-title>
<source><![CDATA[Current Opinion in Allergy and Clinical Immunology]]></source>
<year>2012</year>
<volume>12</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>82-90</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tashkin D]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Roflumilast the new orally active, selective phophodiesterase-4 inhibitor, for the treatment of COPD]]></article-title>
<source><![CDATA[Expert Opinion on Pharmacotherapy]]></source>
<year>2014</year>
<volume>15</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>85-96</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barnes]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inflammatory mechanisms in patients with chronic obstructive pulmonary disease]]></article-title>
<source><![CDATA[Journal of Allergy and Clinical Immunology]]></source>
<year>2016</year>
<volume>138</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>16-27</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ezzati Givi]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Redegeld]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Folkerts]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Mortaz]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dendritic Cells in Pathogenesis of COPD]]></article-title>
<source><![CDATA[Current Pharmaceutical Design]]></source>
<year>2012</year>
<volume>18</volume>
<page-range>2329-35</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shao]]></surname>
<given-names><![CDATA[MXG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor converting enzyme in human airway epithelial (NCI-H292) cells]]></article-title>
<source><![CDATA[AJP: Lung Cellular and Molecular Physiology]]></source>
<year>2004</year>
<volume>287</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>L420-L7</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Polverino]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Seys]]></surname>
<given-names><![CDATA[LJM]]></given-names>
</name>
<name>
<surname><![CDATA[Bracke]]></surname>
<given-names><![CDATA[KR]]></given-names>
</name>
<name>
<surname><![CDATA[Owen]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[B cells in chronic obstructive pulmonary disease moving to center stage]]></article-title>
<source><![CDATA[AJP: Lung Cellular and Molecular Physiology]]></source>
<year>2016</year>
<volume>311</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>L687-L95</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Calle Rubio]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Chacón]]></surname>
<given-names><![CDATA[BM]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez Hermosa]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Exacerbation of chronic obstructive pulmonary disease]]></article-title>
<source><![CDATA[Arch Bronconeumol]]></source>
<year>2010</year>
<volume>46</volume>
<numero>^s7</numero>
<issue>^s7</issue>
<supplement>7</supplement>
<page-range>21-5</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McNicholas]]></surname>
<given-names><![CDATA[WT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Impact of sleep in COPD]]></article-title>
<source><![CDATA[Chest]]></source>
<year>2000</year>
<volume>117</volume>
<numero>^s2</numero>
<issue>^s2</issue>
<supplement>2</supplement>
<page-range>48S-53S</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Borsboom]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[van Pelt]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[van Houwelingen]]></surname>
<given-names><![CDATA[HC]]></given-names>
</name>
<name>
<surname><![CDATA[van Vianen]]></surname>
<given-names><![CDATA[BG]]></given-names>
</name>
<name>
<surname><![CDATA[Schouten]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Quanjer]]></surname>
<given-names><![CDATA[PH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diurnal variation in lung function in subgroups from two Dutch populations consequences for longitudinal analysis]]></article-title>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>1999</year>
<volume>159</volume>
<page-range>1163-71</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García-Río]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Calle]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Burgos]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Casan]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Del Campo]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spirometry Spanish Society of Pulmonology and Thoracic Surgery (SEPAR)]]></article-title>
<collab>Galdiz JBet al</collab>
<source><![CDATA[Arch Bronconeumol]]></source>
<year>2013</year>
<volume>49</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>388-401</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schett]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Sloan]]></surname>
<given-names><![CDATA[VS]]></given-names>
</name>
<name>
<surname><![CDATA[Stevens]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Schafer]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Apremilast a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases]]></article-title>
<source><![CDATA[Therapeutic advances in musculoskeletal disease]]></source>
<year>2010</year>
<volume>2</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>271-8</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
