<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422020000300007</article-id>
<article-id pub-id-type="doi">10.22201/fm.24484865e.2019.63.3.02</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Metapneumovirus humano: epidemiología y posibles tratamientos profilácticos]]></article-title>
<article-title xml:lang="en"><![CDATA[Human Metapneumovirus: Epidemiology and Possible Prophylactic Treatments]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Solís-Rodríguez]]></surname>
<given-names><![CDATA[Marcela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alpuche-Solís]]></surname>
<given-names><![CDATA[Ángel G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tirado-Mendoza]]></surname>
<given-names><![CDATA[Rocío G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Potosino de Investigación Científica y Tecnológica Laboratorio de Biología Molecular de Plantas ]]></institution>
<addr-line><![CDATA[San Luis Potosí S.L.P.]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México Laboratorio de Biología del Citoesqueleto y Virología ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>63</volume>
<numero>3</numero>
<fpage>7</fpage>
<lpage>18</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422020000300007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422020000300007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422020000300007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen En el 2001, se identificó en Holanda al metapneumovirus humano (hMPV) como un &#8220;nuevo&#8221; agente etiológico causante de infecciones respiratorias agudas en infantes menores de 5 años; sin embargo, también se ha aislado en personas de la tercera edad e inmunocomprometidos. Este virus se considera como el segundo agente etiológico en enfermedades agudas del tracto respiratorio. En la actualidad, el costo estimado de las infecciones respiratorias agudas (IRA) en nuestro país es de 9,000 dólares estadounidenses por paciente hospitalizado. El hMPV es un miembro del género Metapneumovirus, familia Pneumoviridae, que pertenece al orden de los Mononegavirales, correspondiente a virus de ácido ribonucleico (RNA) monocatenario negativo, que consta de 8 genes en el orden 3&#8217;-N-P-M-F-M2-SH-G-L-5&#8217;, y que codifica para 9 proteínas. De estas proteínas, la glicoproteína de fusión F está altamente conservada en el género Metapneumovirus y es el mayor determinante antigénico, y al no existir aún vacuna aprobada para este virus, se ha utilizado como un epítopo candidato para el diseño de una vacuna que confiera inmunidad al hospedero o como un blanco terapéutico en la creación de péptidos antivirales que inhiban la fusión del virus a su célula blanco y se evite la infección en sujetos de alto riesgo de contagio, ya que en la actualidad no se ha aprobado por la COFEPRIS ningún tratamiento profiláctico contra hMPV.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract In 2001 in the Netherlands, Human metapneumovirus (hMPV) was identified as a &#8220;new&#8221; etiologic agent causing acute respiratory infections in children younger than 5 years old; however, it has also been isolated in the elderly and immunocompromised people. This virus is considered the second etiological agent in acute diseases of the respiratory tract. Currently, the estimated cost of IRAs in our country is of 9,000 USD per inpatient. hMPV is a member of the genus Metapneumovirus, family Pneumoviridae, and it belongs to the order Mononegavirales that is part of the negative single-stranded ribonucleic acid (RNA) virus, consisting of eight genes ordered: 3&#8217;-N-P-M-F-M2-SH-G-L-5 &#8216;, and which encodes for 9 proteins. Of these proteins, the F fusion glycoprotein is highly conserved in the genus Metapneumovirus, and is the major antigenic determinant, and because an approved vaccine doesn&#8217;t exist, it has been used as a candidate epitope for the design of a vaccine that confers host immunity or as a therapeutic target in the creation of antiviral peptides that inhibit the fusion of the virus to its target cell and to avoid infection in subjects at high risk of contagion since there is currently none accepted by COFEPRIS as a prophylactic treatment against hMPV.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hMPV]]></kwd>
<kwd lng="es"><![CDATA[infecciones respiratorias]]></kwd>
<kwd lng="es"><![CDATA[epítopos]]></kwd>
<kwd lng="es"><![CDATA[proteína F]]></kwd>
<kwd lng="es"><![CDATA[vacunas]]></kwd>
<kwd lng="en"><![CDATA[hMPV]]></kwd>
<kwd lng="en"><![CDATA[respiratory infections]]></kwd>
<kwd lng="en"><![CDATA[epitopes]]></kwd>
<kwd lng="en"><![CDATA[protein F]]></kwd>
<kwd lng="en"><![CDATA[vaccines]]></kwd>
</kwd-group>
</article-meta>
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