<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422020000200007</article-id>
<article-id pub-id-type="doi">10.22201/fm.24484865e.2020.63.2.02</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Antifúngicos poliénicos. Mecanismo de acción y aplicaciones]]></article-title>
<article-title xml:lang="en"><![CDATA[Polyenic Antifungals. Action Mechanisms and their Applications]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivera-Toledo]]></surname>
<given-names><![CDATA[Evelyn]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez-Delgadillo]]></surname>
<given-names><![CDATA[Alan Uriel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Manzano-Gayosso]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Departamento de Microbiología y Parasitología]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Departamento de Microbiología y Parasitología]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<volume>63</volume>
<numero>2</numero>
<fpage>7</fpage>
<lpage>17</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422020000200007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422020000200007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422020000200007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Los primeros compuestos con actividad antifúngica específica fueron identificados a mediados del siglo pasado como un producto del metabolismo secundario de bacterias del orden Actinomycetales, y su uso en la clínica redujo de manera importante la morbilidad y la mortalidad relacionadas con infecciones severas por hongos de varios géneros. Muchos de estos compuestos biosintéticos se caracterizan por tener una estructura química de tipo poliénico, con un número variable de dobles enlaces carbono-carbono. Actualmente, además de los fármacos poliénicos, existe otro tipo de compuestos con actividad antimicótica, como los azoles, que se utilizan con mayor frecuencia y que presentan menor toxicidad en los pacientes; sin embargo, se han documentado casos de falla terapéutica con tales compuestos, por lo que el uso de los poliénicos se ha mantenido como la mejor alternativa en esos casos. El presente trabajo brinda información acerca de las propiedades y las aplicaciones de los antifúngicos poliénicos teniendo como modelo a la anfotericina B.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The first compounds with specific antifungal activity were identified in the middle of the last century as a product of the secondary metabolism of bacteria of the order Actinomycetales, and their clinical use significantly diminished the morbidity and mortality associated with severe fungal infections. Many of such biosynthetic compounds are characterized by a chemical polygenic structure, with a variable number of carbon-carbon double bonds. Currently, besides polygenic antimycotics, there are other antifungal agents, such as the azole compounds, that have less toxicity in patients; however, cases of therapeutic failure with such compounds have been documented, therefore, the use of polygenics is still the best alternative in such cases. This review presents data about the properties and applications of antifungal-polygenic compounds using amphotericin B as a model.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Anfotericina B]]></kwd>
<kwd lng="es"><![CDATA[antifúngicos poliénicos]]></kwd>
<kwd lng="es"><![CDATA[ergosterol.]]></kwd>
<kwd lng="en"><![CDATA[Amphotericin B]]></kwd>
<kwd lng="en"><![CDATA[antifungal polyenes]]></kwd>
<kwd lng="en"><![CDATA[ergosterol]]></kwd>
</kwd-group>
</article-meta>
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