<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422019000200022</article-id>
<article-id pub-id-type="doi">10.22201/fm.24484865e.2019.62.2.05</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Diagnóstico incidental de enfermedad de Erdheim-Chester en paciente con presentación inusual]]></article-title>
<article-title xml:lang="en"><![CDATA[Incidental diagnosis of Erdheim-Chester disease in a patient with unusual presentation]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cisneros Bernal]]></surname>
<given-names><![CDATA[Ernesto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez Rodríguez]]></surname>
<given-names><![CDATA[Eulalio Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soto Salazar]]></surname>
<given-names><![CDATA[Laura Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Christus Muguerza Departamento de Anatomía Patológica ]]></institution>
<addr-line><![CDATA[Saltillo Coahuila]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Facultad de Medicina  ]]></institution>
<addr-line><![CDATA[Saltillo Coahuila]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>62</volume>
<numero>2</numero>
<fpage>22</fpage>
<lpage>30</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422019000200022&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422019000200022&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422019000200022&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La enfermedad de Erdheim-Chester (ECD) es una forma extraña de histiocitosis de células no Langerhans, que afecta principalmente a los adultos entre la 5ª y 7ª década de la vida. El diagnóstico se establece por las manifestaciones clínicas, radiológicas, histopatológicas y de inmunohistoquímica, siendo estas últimas [CD68 (+), CD1a (-) y S100] de comportamiento variable. Es una enfermedad rara de la cual solo se han reportado alrededor de 600 casos cuya clínica principal se caracteriza por un compromiso óseo y síntomas generales. Tiene gravedad y pronóstico variables en función del compromiso orgánico. Se presenta un caso clínico de un paciente del sexo masculino de 45 años a quien se realiza el diagnóstico histopatológico e inmunohistoquímico incidental de enfermedad de Erdheim-Chester tras presentar rotura esplénica espontánea sin alguna otra afección documentada, se trata de una presentación inusual de esta rara enfermedad. Se realiza una revisión actualizada del tema y de los criterios diagnósticos de la ECD.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Erdheim-Chester disease (ECD) is a rare presentation of non-Langerhans cell histiocytosis, which affects adults that are between 50 and 70 years old. The diagnosis is confirmed by clinical, radiological and histopathological manifestations and immunohistochemistry markers (CD68 (+), CD1a (-) and S100 with variable behavior). It is a rare disease of which only about 600 cases have been reported, whose main clinic is characterized by bone involvement and general symptoms. It has variable severity and prognosis depending on the organic commitment. We present a clinical case of a 45-year-old male patient who underwent histopathological and incidental immunohistochemical diagnosis of Erdheim-Chester disease after presenting spontaneous splenic rupture without any other documented condition, this is an unusual presentation of this rare disease. An updated review of the subject and the diagnostic criteria of the ECD is being performed.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Histiocitosis]]></kwd>
<kwd lng="es"><![CDATA[histiocitosis de células no Langerhans]]></kwd>
<kwd lng="es"><![CDATA[enfermedad de Erdheim-Chester]]></kwd>
<kwd lng="en"><![CDATA[Histiocytosis]]></kwd>
<kwd lng="en"><![CDATA[histiocytosis of non-Langerhans cells]]></kwd>
<kwd lng="en"><![CDATA[Erdheim-Chester disease]]></kwd>
</kwd-group>
</article-meta>
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<year>2018</year>
</nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pernick]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pernick]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[]]></source>
<year>2018</year>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
