<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422016000100006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Especies reactivas de oxígeno, sepsis y teoría metabólica del choque séptico]]></article-title>
<article-title xml:lang="en"><![CDATA[Reactive oxygen species, sepsis and metabolic theory of the septic shock]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carrillo Esper]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz Ponce Medrano]]></surname>
<given-names><![CDATA[Juan Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peña Pérez]]></surname>
<given-names><![CDATA[Carlos Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores Rivera]]></surname>
<given-names><![CDATA[Oscar Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Neri Maldonado]]></surname>
<given-names><![CDATA[Rosalinda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zepeda Mendoza]]></surname>
<given-names><![CDATA[Adriana Denisse]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Calatayud]]></surname>
<given-names><![CDATA[Ángel Augusto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortiz Trujillo]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Escuela Médico Naval  ]]></institution>
<addr-line><![CDATA[D.F. ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Fundación Clínica Médica Sur  ]]></institution>
<addr-line><![CDATA[D.F. ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Escuela Médico Naval  ]]></institution>
<addr-line><![CDATA[D.F. ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Escuela Médico Naval Hospital General Naval de Alta Especialidad ]]></institution>
<addr-line><![CDATA[D.F. ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Fundación Clínica Médica Sur  ]]></institution>
<addr-line><![CDATA[D.F. ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Escuela Médico Naval  ]]></institution>
<addr-line><![CDATA[D.F. ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2016</year>
</pub-date>
<volume>59</volume>
<numero>1</numero>
<fpage>6</fpage>
<lpage>18</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422016000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422016000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422016000100006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La sepsis es una de las principales causas de mortalidad en la unidad de terapia intensiva. El término especies reactivas de oxígeno (ERO) incluye moléculas con un electrón impar, llamadas radicales libres, como el anión superóxido, y también agentes oxidados como el peróxido de hidrógeno. Las ERO pueden reaccionar con muchas moléculas y pueden producir un daño no controlado; sin embargo, también tienen un papel fundamental en el metabolismo celular. El estrés oxidante es el resultado de la respuesta inflamatoria asociada a la sepsis que produce cambios en la función mitocondrial y en la microcirculación. El objetivo de este trabajo es revisar el papel de las ERO en sepsis y nuevos conceptos relacionados con la teoría metabólica del choque séptico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Sepsis remains the most common cause of death in the intensive care unit. The term Reactive Oxygen Species (ROS) includes molecules with an unpaired electron, called free radicals, such as superoxide anion, and also oxidant agents such as hydrogen peroxide. ROS can react with several molecules and induce an uncontrolled damage in a variety of biomolecules. On the other hand, ROS have essential roles in cell function. Marked oxidative stress as a result of the inflammatory responses inherent with sepsis initiates changes in mitochondrial function and microcirculation. The aim of this paper is to review the roll of ROS in sepsis and new concepts related to the metabolic theory of septic shock.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Sepsis]]></kwd>
<kwd lng="es"><![CDATA[choque séptico]]></kwd>
<kwd lng="es"><![CDATA[especies reactivas de oxígeno]]></kwd>
<kwd lng="en"><![CDATA[Sepsis]]></kwd>
<kwd lng="en"><![CDATA[septic shock]]></kwd>
<kwd lng="en"><![CDATA[reactive oxygen species]]></kwd>
</kwd-group>
</article-meta>
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