<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422014000200025</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Mielinolisis central y periférica de la protuberancia: presentación de un caso y revisión de la literatura]]></article-title>
<article-title xml:lang="en"><![CDATA[Central and peripheral pontine Myelinolysis: case report and review of literature]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Madinaveitia Turcott]]></surname>
<given-names><![CDATA[Jaime]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Laventman Grimberg]]></surname>
<given-names><![CDATA[Jaime]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fraind Maya]]></surname>
<given-names><![CDATA[Gabriel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Ángeles Lomas Departamento de Medicina Interna ]]></institution>
<addr-line><![CDATA[Huixquilucan Edo. de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Ángeles Lomas Servicio de Neurología ]]></institution>
<addr-line><![CDATA[Huixquilucan Edo. de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Anáhuac  ]]></institution>
<addr-line><![CDATA[ México, DF]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2014</year>
</pub-date>
<volume>57</volume>
<numero>2</numero>
<fpage>25</fpage>
<lpage>30</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422014000200025&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422014000200025&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422014000200025&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La mielinolisis central de la protuberancia o síndrome de desmielinización osmolar, es un padecimiento que se asocia a pacientes con hiponatremia grave, a los cuales se les realiza una corrección brusca del sodio4. Se manifiesta como parálisis pseudobulbar que se presenta con: tetraparesia, encefalopatía que en ocasiones se puede presentar con rigidez, ataxia y movimientos anormales. Se trata de una desmielinización no inflamatoria secundaria al edema neuronal intenso tanto a nivel del puente como en otras zonas extrapontinas10. Es una patología infrecuente, sin embargo tiene mal pronóstico y la terapia con rehabilitación es el único tratamiento. El objetivo de la presente comunicación es informar el caso de un hombre de 63 años con cuadro de déficit neurológico progresivo posterior a un evento quirúrgico y corrección rápida de hiponatremia que presentó en días posteriores, mielinolisis pontina y extrapontina con diagnóstico por imagen y resonancia magnética. El paciente ameritó un largo periodo de hospitalización y rehabilitación, sin embargo las secuelas neurológicas actuales no son incapacitantes. Es imprescindible reconocer la hiponatremia y corregirla de manera correcta para evitar este tipo de complicaciones.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Central pontine myelinolysis or osmolar demielinization syndrome is a very wellknown disorder in patients with severe hyponatremia that undergo to a rapid sodium replacement. It is clinically described as a pseudobulbar palsy, with tetraparesis, and encephalopathy, that can also show generalized rigidity, ataxia and the presence of abnormal movements. It consists of a non-inflammatory demielinization secondary to neuronal swelling or edema, at the pontine level and in other extrapontine locations. It is an infrequent pathology that carries a bad prognosis and where the only available treatment is prolonged rehabilitation. Herein we inform the case of a 63 year old male, with a progressive neurological deficit following a surgical intervention and rapid replacement of a severe hyponatremia. The patient required a prolonged in hospital stay and further rehabilitation, although the neurological sequels actually are not disabling. It is essential to recognize hyponatremia and to perform an adequate correction of sodium levels to avoid this complication.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Mielinolisis]]></kwd>
<kwd lng="es"><![CDATA[desmielinización]]></kwd>
<kwd lng="es"><![CDATA[hiponatremia]]></kwd>
<kwd lng="es"><![CDATA[parálisis pseudobulbar]]></kwd>
<kwd lng="es"><![CDATA[osmolaridad]]></kwd>
<kwd lng="en"><![CDATA[Myelinolysis]]></kwd>
<kwd lng="en"><![CDATA[demielinization]]></kwd>
<kwd lng="en"><![CDATA[hiponatremia]]></kwd>
<kwd lng="en"><![CDATA[pseudobulbar palsy]]></kwd>
<kwd lng="en"><![CDATA[osmolarity]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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