<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0016-3813</journal-id>
<journal-title><![CDATA[Gaceta médica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. Méd. Méx]]></abbrev-journal-title>
<issn>0016-3813</issn>
<publisher>
<publisher-name><![CDATA[Academia Nacional de Medicina de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-38132025000300008</article-id>
<article-id pub-id-type="doi">10.24875/gmm.m25000982</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Adaptación y validación de la escala mexicana de evaluación de la calidad de vida en adultos con deficiencia de hormona de crecimiento (QoL-AGHDA)]]></article-title>
<article-title xml:lang="en"><![CDATA[Adaptation and validation of the Mexican Quality of Life Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cajigas-Silva]]></surname>
<given-names><![CDATA[Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Thorpe]]></surname>
<given-names><![CDATA[Jeanette]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Spray]]></surname>
<given-names><![CDATA[Isobel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Grzeda]]></surname>
<given-names><![CDATA[Mariusz T.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Portocarrero-Ortiz]]></surname>
<given-names><![CDATA[Lesly A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez" Servicio de Neuroendocrinología ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Galen Research Ltd  ]]></institution>
<addr-line><![CDATA[Manchester ]]></addr-line>
<country>Reino Unido</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>161</volume>
<numero>3</numero>
<fpage>296</fpage>
<lpage>303</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0016-38132025000300008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0016-38132025000300008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0016-38132025000300008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: La deficiencia de hormona de crecimiento (GHD), causada por disminución en la secreción por la hipófisis, tiene repercusiones clínicas que impactan en la composición corporal, parámetros metabólicos y puede tener impacto negativo en la calidad de vida. El QoL-AGHDA es un instrumento utilizado para evaluar la calidad de vida de adultos con GHD.  Objetivos: Validar el QoL-AGHDA para uso en México.  Material y métodos: Primera fase: Traducción del QoL-AGHDA al español hablado en México. La validez de contenido y cara fue evaluada con 10 entrevistas de despeje cognitivo (CDIs). Segunda fase: La versión mexicana del QoL-AGHDA fue aplicada a 40 pacientes en dos ocasiones. Las propiedades distributivas fueron evaluadas mediante estadística descriptiva. Se calculó &#945; de Cronbach para la consistencia interna y correlación de Spearman para evaluar la confiabilidad.  Resultados: El QoL-AGHDA para mexicanos mostró alta consistencia interna, coeficiente &#945; de Cronbach de 0.91 y 0.92. La confiabilidad fue excelente, con una correlación de Spearman de 0.95.  Conclusiones: La adaptación mexicana del QoL-AGHDA demostró buenas propiedades psicométricas, apoyando su uso en futuros estudios para evaluar la calidad de vida en adultos con GHD en México.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Growth hormone deficiency (GHD), caused by decreased secretion of growth hormone by the pituitary, has clinical repercussions that impact body composition, metabolic parameters, and can have a negative impact on quality of life. The Quality of Life in Adults with Growth Hormone Deficiency (QoL-AGHDA) is a patient-reported outcome measure used to assess the quality of life of adults with GHD.  Objectives: The objective of this study was to validate the QoL-AGHDA for use in Mexico.  Materials and methods: First phase: Translation of the QoL-AGHDA into Spanish as spoken in Mexico. Face and content validity were assessed through 10 Cognitive debriefing interviews. Second phase: The Mexican version of the QoLAGHDA was administered to 40 patients on two occasions for subsequent analysis. The distributional properties of the measure were explored through descriptive statistics. Cronbach’s &#945; was calculated for internal consistency, and Spearman’s correlation coefficient was used to assess reliability.  Results: The QoL-AGHDA for Mexicans showed high internal consistency, with Cronbach's &#945; coefficients of 0.91 and 0.92. Test-retest reliability was excellent, with a Spearman's correlation coefficient of 0.95.  Conclusion: The Mexican adaptation of the QoL-AGHDA demonstrated good psychometric properties, supporting its use in future studies to assess quality of life in adults with GHD in Mexico.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Adaptación]]></kwd>
<kwd lng="es"><![CDATA[Validación]]></kwd>
<kwd lng="es"><![CDATA[Deficiencia de hormona de crecimiento en adultos]]></kwd>
<kwd lng="es"><![CDATA[Calidad de vida]]></kwd>
<kwd lng="es"><![CDATA[QoL-AGHDA]]></kwd>
<kwd lng="en"><![CDATA[Adaptation]]></kwd>
<kwd lng="en"><![CDATA[Validation]]></kwd>
<kwd lng="en"><![CDATA[Adult growth hormone deficiency]]></kwd>
<kwd lng="en"><![CDATA[Quality of life]]></kwd>
<kwd lng="en"><![CDATA[QoL-adult growth hormone deficiency]]></kwd>
</kwd-group>
</article-meta>
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