<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0016-3813</journal-id>
<journal-title><![CDATA[Gaceta médica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. Méd. Méx]]></abbrev-journal-title>
<issn>0016-3813</issn>
<publisher>
<publisher-name><![CDATA[Academia Nacional de Medicina de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-38132025000300001</article-id>
<article-id pub-id-type="doi">10.24875/gmm.24000397</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Inmunogenicidad y seguridad de las vacunas tetravalentes contra el dengue: una revisión sistemática de ensayos clínicos]]></article-title>
<article-title xml:lang="en"><![CDATA[Immunogenicity and safety of tetravalent dengue vaccines: a systematic review of clinical trials]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montes-Sevilla]]></surname>
<given-names><![CDATA[Lenyn D.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Montes]]></surname>
<given-names><![CDATA[Paul E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez-García]]></surname>
<given-names><![CDATA[Erick]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guzmán-Ríos]]></surname>
<given-names><![CDATA[Edgar D.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores-Reyes]]></surname>
<given-names><![CDATA[Marco F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Acosta-Gutiérrez]]></surname>
<given-names><![CDATA[Gilberto H.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales-Hernández]]></surname>
<given-names><![CDATA[Osmara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Girón-Pérez]]></surname>
<given-names><![CDATA[Manuel I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Departamento de Cirugía General ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Departamento de Medicina General, Hospital General Dr. Aquiles Calles Ramírez ]]></institution>
<addr-line><![CDATA[Tepic Nayarit]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Servicios de Salud de Nayarit Centro de Justicia Familiar ]]></institution>
<addr-line><![CDATA[Tepic Nayarit]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Nacional de Cardiología Ignacio Chávez Departamento de Biología Molecular ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Departamento de Dermatología ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Universidad Autónoma de Nayarit unidad Nayarit Laboratorio Nacional para la Investigación en Inocuidad Alimentaria]]></institution>
<addr-line><![CDATA[Tepic Nayarit]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>161</volume>
<numero>3</numero>
<fpage>239</fpage>
<lpage>248</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0016-38132025000300001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0016-38132025000300001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0016-38132025000300001&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Las vacunas tetravalentes contra el dengue han sido objeto de estudio, especialmente en la prevención de casos graves de la enfermedad. Sin embargo, la variabilidad en los resultados y la calidad metodológica de los estudios existentes plantean interrogantes sobre su efectividad. El objetivo es valuar la inmunogenicidad y la seguridad de las vacunas tetravalentes en comparación con placebo en la prevención de casos graves de dengue mediante una revisión sistemática de ensayos clínicos aleatorizados. Se realizó una búsqueda sistemática en las bases de datos PubMed, Scopus y Web of Science, incluyendo ensayos clínicos aleatorizados publicados entre 2019 y 2024. Se aplicaron criterios de inclusión y exclusión para seleccionar los estudios relevantes, y se evaluó la calidad metodológica utilizando el nivel de evidencia del Oxford Centre for Evidence Based Medicine (OCEBM). Se incluyeron seis ensayos clínicos aleatorizados, con un total de 24,249 participantes. Los estudios evaluaron desenlaces como la incidencia de dengue grave, la seropositividad y la respuesta inmunitaria a las vacunas TV003 y TV005. Las vacunas tetravalentes muestran un panorama prometedor en la reducción de la incidencia de dengue grave, aunque se identificaron limitaciones en los diseños de los estudios y heterogeneidad en las poblaciones estudiadas. Se requieren más investigaciones para confirmar la eficacia y la seguridad en diversas poblaciones.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Tetravalent dengue vaccines have been the subject of study, particularly in the prevention of severe cases of the disease. However, the variability in results and the methodological quality of existing studies raise questions about their effectiveness. The objective is to evaluate the immunogenicity and safety of tetravalent vaccines compared to placebo in the prevention of severe dengue cases through a systematic review of randomized clinical trials. A systematic search was conducted in databases PubMed, Scopus, and Web of Science, including randomized clinical trials published between 2019 and 2024. Inclusion and exclusion criteria were applied to select relevant studies, and methodological quality was assessed using the level of evidence from the Oxford Centre for Evidence-Based Medicine (OCEBM). Six randomized clinical trials were included, with a total of 24,249 participants. The studies evaluated outcomes such as the incidence of severe dengue, seropositivity, and immune response to the vaccines TV003 and TV005. Tetravalent vaccines show a promising outlook in reducing the incidence of severe dengue, although limitations were identified in study designs and heterogeneity in the studied populations. Further research is needed to confirm efficacy and safety in diverse populations.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Vacunas contra el dengue]]></kwd>
<kwd lng="es"><![CDATA[Dengue grave]]></kwd>
<kwd lng="es"><![CDATA[Revisión sistemática]]></kwd>
<kwd lng="es"><![CDATA[Ensayos clínicos]]></kwd>
<kwd lng="en"><![CDATA[Dengue vaccines]]></kwd>
<kwd lng="en"><![CDATA[Severe Dengue]]></kwd>
<kwd lng="en"><![CDATA[Systematic review]]></kwd>
<kwd lng="en"><![CDATA[Clinical trials]]></kwd>
</kwd-group>
</article-meta>
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