<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0016-3813</journal-id>
<journal-title><![CDATA[Gaceta médica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. Méd. Méx]]></abbrev-journal-title>
<issn>0016-3813</issn>
<publisher>
<publisher-name><![CDATA[Academia Nacional de Medicina de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-38132025000200001</article-id>
<article-id pub-id-type="doi">10.24875/gmm.24000394</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Enfermedad por reflujo gastroesofágico y embarazo: recomendaciones para un tratamiento seguro]]></article-title>
<article-title xml:lang="en"><![CDATA[Gastroesophageal reflux disease and pregnancy: recommendations for safe treatment]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortiz-Olvera]]></surname>
<given-names><![CDATA[Nayeli]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ochoa-Maya]]></surname>
<given-names><![CDATA[Juan Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Martínez]]></surname>
<given-names><![CDATA[Marina A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social Unidad Médica de Alta Especialidad Servicio de Gastroenterología]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social Unidad Médica de Alta Especialidad Laboratorio de Motilidad Gastrointestinal]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<volume>161</volume>
<numero>2</numero>
<fpage>125</fpage>
<lpage>132</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0016-38132025000200001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0016-38132025000200001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0016-38132025000200001&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La enfermedad por reflujo gastroesofágico (ERGE) es frecuente durante el embarazo, pues afecta hasta al 80% de las embarazadas. El tratamiento pretende aliviar los síntomas y no dañar al binomio. Nuestro objetivo es brindar orientación sobre un tratamiento seguro de la ERGE en el embarazo. Se realizó una búsqueda electrónica de la literatura en idioma inglés en MEDLINE, PubMed y Cochrane, para identificar ensayos controlados aleatorizados, estudios observacionales, recomendaciones de manejo y revisiones sobre la ERGE y su tratamiento durante el embarazo. El periodo de búsqueda se definió de 1992 a 2024. El tratamiento durante el embarazo debe ser escalonado, comenzando con cambios del estilo de vida. Si los síntomas son graves, se debe iniciar con antiácidos que contengan calcio o alginatos, como primera medida farmacológica (recomendación de grado A). Si los síntomas persisten, se puede introducir sucralfato (recomendación de grado C); seguido de un antagonista del receptor de histamina 2 (recomendación de grado B). Los inhibidores de la bomba de protones están reservados para mujeres con síntomas intratables o ERGE complicada; todos ellos son de categoría B de la Food and Drug Administration, excepto el omeprazol, que es de categoría C (recomendación de grado C). Existen fármacos que están contraindicados durante el embarazo, y otros que no han sido estudiados en esta situación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Gastroesophageal reflux disease (GERD) is common during pregnancy, affecting up to 80% of pregnant women. Treatment aims to relieve symptoms and not harm the fetus. Our objective is to provide guidance on the safe treatment of GERD in pregnancy. An electronic search of the English-language literature was performed in MEDLINE, PubMed, and Cochrane, to identify randomized controlled trials, observational studies, management recommendations, and reviews of GERD and its treatment during pregnancy. The search period was defined from 1992 to 2024. Treatment during pregnancy should be gradual, starting with lifestyle changes. If symptoms are severe, calcium-containing antacids or alginates should be started as the first pharmacological measure (grade A recommendation). If symptoms persist, sucralfate may be introduced (grade C recommendation), followed by a histamine-2 receptor antagonist (grade B recommendation). Proton pump inhibitors are reserved for women with intractable symptoms or complicated GERD; all are Food and Drug Administration category B drugs except omeprazole, which is category C (grade C recommendation). There are drugs that are contraindicated during pregnancy, and others that have not been thoroughly studied in this situation.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Antiácidos en embarazo]]></kwd>
<kwd lng="es"><![CDATA[Inhibidor de la bomba de protones]]></kwd>
<kwd lng="es"><![CDATA[Reflujo gastroesofágico]]></kwd>
<kwd lng="es"><![CDATA[Sucralfato]]></kwd>
<kwd lng="en"><![CDATA[Antacids in pregnancy]]></kwd>
<kwd lng="en"><![CDATA[Gastroesophageal reflux]]></kwd>
<kwd lng="en"><![CDATA[Proton pump inhibitors]]></kwd>
<kwd lng="en"><![CDATA[Sucralfate]]></kwd>
</kwd-group>
</article-meta>
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