<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0016-3813</journal-id>
<journal-title><![CDATA[Gaceta médica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. Méd. Méx]]></abbrev-journal-title>
<issn>0016-3813</issn>
<publisher>
<publisher-name><![CDATA[Academia Nacional de Medicina de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-38132024000500001</article-id>
<article-id pub-id-type="doi">10.24875/gmm.24000123</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Potenciales biomarcadores proteicos de infiltración al sistema nervioso central en leucemia linfoblástica aguda infantil]]></article-title>
<article-title xml:lang="en"><![CDATA[Potential protein biomarkers of central nervous system infiltration in childhood acute lymphoblastic leukemia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rangel-Cova]]></surname>
<given-names><![CDATA[Laura S.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soto-Álvarez]]></surname>
<given-names><![CDATA[Silverio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Estudillo]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Huerta-Núñez]]></surname>
<given-names><![CDATA[Lidia F. E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro de Investigación del Ejército y Fuerza Aérea Mexicana, Universidad del Ejército y Fuerza Aérea Mexicana Escuela Militar de Graduados de Sanidad Laboratorio de Farmacología]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez Laboratorio de Reprogramación Celular ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2024</year>
</pub-date>
<volume>160</volume>
<numero>5</numero>
<fpage>489</fpage>
<lpage>497</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0016-38132024000500001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0016-38132024000500001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0016-38132024000500001&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La leucemia linfoblástica aguda (LLA) es la neoplasia en niños más frecuente en el mundo y la principal causa de muerte por cáncer en menores de 18 años, por lo que es un grave problema de salud. Una de las complicaciones de la enfermedad es la infiltración de células leucémicas al sistema nervioso central (SNC), la cual únicamente se detecta en 3 a 5 % de los niños al momento del diagnóstico, debido a falta de sensibilidad y especificidad de la prueba de referencia, lo que tiene repercusiones en el pronóstico y evolución de la enfermedad, de ahí la necesidad de nuevos biomarcadores de infiltración. Por lo anterior, esta revisión se enfoca en la importancia de la proteómica del líquido cefalorraquídeo (LCR) y los biomarcadores proteicos como posibles candidatos para respaldar el diagnóstico en pacientes pediátricos con LLA que presentan infiltración al SNC, con especial énfasis en las proteínas L-selectina, IL2, sIL2R, VEGFR1, sVEGFR2, SPP1, IL7, IL7R, TIMP1, LGALS3BP, AHSG, integrina-&#945;6, A2M, HRG, C4A, KLK6, CNDP1, ApoA1 y CFH. Finalmente, también se proporciona una visión general de los métodos de análisis de los biomarcadores en el LCR utilizados para conocer más de la leucemia con afectación al SNC.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Acute lymphoblastic leukemia (ALL) is the most common neoplasia among children worldwide, and the main cause of death by cancer in patients with less than 18 years, thus representing a serious health concern. One problem of ALL is the infiltration of leukemic cells in the central nervous system (CNS), which is only detected in the 3-5% of children in their diagnostic due to a lack of sensibility and specificity, which compromises an efficient prognostic and follow-up of the disease. This drawback demands the search of novel biomarkers of infiltration. Therefore, this review focuses on 1) the relevance of cerebrospinal fluid proteomics and protein biomarkers as possible candidates to aim in the diagnostic of pediatric patients with ALL that display CNS infiltration and 2) a general perspective of the methods for analyzing biomarkers in the CSF to further comprehend the leukemia in the CNS.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Biomarcadores]]></kwd>
<kwd lng="es"><![CDATA[Espectrometría de masas]]></kwd>
<kwd lng="es"><![CDATA[Leucemia linfoblástica aguda]]></kwd>
<kwd lng="es"><![CDATA[Líquido cefalorraquídeo]]></kwd>
<kwd lng="es"><![CDATA[Sistema nervioso central]]></kwd>
<kwd lng="en"><![CDATA[Biomarkers]]></kwd>
<kwd lng="en"><![CDATA[Mass spectrometry]]></kwd>
<kwd lng="en"><![CDATA[Acute lymphoblastic leukemia]]></kwd>
<kwd lng="en"><![CDATA[Cerebrospinal fluid]]></kwd>
<kwd lng="en"><![CDATA[Central nervous system]]></kwd>
</kwd-group>
</article-meta>
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