<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0016-3813</journal-id>
<journal-title><![CDATA[Gaceta médica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. Méd. Méx]]></abbrev-journal-title>
<issn>0016-3813</issn>
<publisher>
<publisher-name><![CDATA[Academia Nacional de Medicina de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-38132023000400345</article-id>
<article-id pub-id-type="doi">10.24875/gmm.m23000782</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Función antiinflamatoria y antioxidante del ácido ursólico en la pancreatitis aguda inducida por ceruleína en ratas]]></article-title>
<article-title xml:lang="en"><![CDATA[Anti-inflammatory and anti-oxidant role of ursolic acid in cerulein-induced acute pancreatitis in rats]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Türko&#287;lu]]></surname>
<given-names><![CDATA[Ahmet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[&#304;bilo&#287;lu]]></surname>
<given-names><![CDATA[&#304;brahim]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Kaplan]]></surname>
<given-names><![CDATA[&#304;brahim]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arslan]]></surname>
<given-names><![CDATA[Serkan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Halil-Öcal]]></surname>
<given-names><![CDATA[&#304;brahim]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gümü&#351;]]></surname>
<given-names><![CDATA[Metehan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Rumeli University Universidad Rumeli ]]></institution>
<addr-line><![CDATA[Estambul ]]></addr-line>
<country>Turquía</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Dicle University Departamento de Patología ]]></institution>
<addr-line><![CDATA[Estambul ]]></addr-line>
<country>Turquía</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Dicle University Departamento de Bioquímica ]]></institution>
<addr-line><![CDATA[Estambul ]]></addr-line>
<country>Turquía</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Dicle University Departamento de Cirugía Pediátrica ]]></institution>
<addr-line><![CDATA[Estambul ]]></addr-line>
<country>Turquía</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital de Formación e Investigación de Ad&#305;yaman Hospital de Formación e Investigación de Ad&#305;yaman ]]></institution>
<addr-line><![CDATA[Estambul ]]></addr-line>
<country>Turquía</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Hospital Reyap Estambul  ]]></institution>
<addr-line><![CDATA[Estambul ]]></addr-line>
<country>Turquía</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<volume>159</volume>
<numero>4</numero>
<fpage>345</fpage>
<lpage>351</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0016-38132023000400345&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0016-38132023000400345&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0016-38132023000400345&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: El ácido ursólico se encuentra en numerosas plantas y se ha informado que tiene efectos antiproteasas, antioxidantes, antiinflamatorios, antimicrobianos, nefroprotectores, hepatoprotectores y cardioprotectores.  Objetivo: Este estudio tuvo como objetivo investigar los efectos del ácido ursólico en la pancreatitis aguda inducida por ceruleína.  Material y métodos: Treinta y dos ratas albinas Wistar fueron asignadas aleatoriamente a cuatro grupos iguales: grupo simulado, grupo de pancreatitis aguda, grupo de tratamiento y grupo de ácido ursólico.  Resultados: Los niveles de amilasa sérica en los grupos de pancreatitis aguda y de tratamiento fueron significativamente más altos que en los otros grupos (p &lt; 0.05). Además, los niveles séricos de IL-1&#946;, IL-6 y TNF-&#945; fueron significativamente más altos en el grupo de pancreatitis aguda en comparación con el grupo de tratamiento. Aunque la actividad oxidante total del tejido pancreático en ambos grupos fue similar, la capacidad antioxidante total del tejido pancreático en el grupo de tratamiento fue significativamente mayor.  Conclusión: Se observó que el ácido ursólico reduce el daño al páncreas y órganos remotos en la pancreatitis aguda, al igual que el estrés oxidativo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Ursolic acid (UA) is found in many plants, and has been reported to have anti-protease, antioxidant, anti-inflammatory, antimicrobial, nephroprotective, hepatoprotective, and cardioprotective effects.  Objective: The purpose of this study was to investigate the effects of ursolic acid in cerulein-induced acute pancreatitis (AP).  Materials and methods: Thirty-two Wistar albino rats were randomly assigned to 4 equal groups: Sham, acute pancreatitis, treatment, and ursolic acid group.  Results: Serum amylase levels in the AP and treatment groups were significantly higher than in the others (p &lt; 0.05). In addition, serum IL-1&#946;, IL-6, and TNF-&#945; levels were significantly higher in the AP group in comparison with the treatment group. Although pancreatic tissue total oxidant activity in the AP and treatment groups was similar, pancreatic tissue total antioxidant capacity was significantly higher in the treatment group than in the AP group.  Conclusions: Damage to the pancreas and remote organs in AP was observed to be reduced by UA. In addition, oxidative stress was observed to be decreased by the effect of UA.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ácido ursólico]]></kwd>
<kwd lng="es"><![CDATA[Actividad oxidante total]]></kwd>
<kwd lng="es"><![CDATA[Capacidad antioxidante total]]></kwd>
<kwd lng="es"><![CDATA[Ceruleína]]></kwd>
<kwd lng="es"><![CDATA[Pancreatitis aguda]]></kwd>
<kwd lng="en"><![CDATA[Ursolic acid]]></kwd>
<kwd lng="en"><![CDATA[Total oxidant activity]]></kwd>
<kwd lng="en"><![CDATA[Total antioxidant capacity]]></kwd>
<kwd lng="en"><![CDATA[Cerulein]]></kwd>
<kwd lng="en"><![CDATA[Acute pancreatitis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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