<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0016-3813</journal-id>
<journal-title><![CDATA[Gaceta médica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. Méd. Méx]]></abbrev-journal-title>
<issn>0016-3813</issn>
<publisher>
<publisher-name><![CDATA[Academia Nacional de Medicina de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-38132021000400352</article-id>
<article-id pub-id-type="doi">10.24875/gmm.20000586</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Cambios regionales de densidad vascular parafoveal en pacientes diabéticos sin retinopatía]]></article-title>
<article-title xml:lang="en"><![CDATA[Regional parafoveal vessel density changes in diabetic patients without retinopathy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escobar-Villado]]></surname>
<given-names><![CDATA[Sheyla L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lima-Gómez]]></surname>
<given-names><![CDATA[Virgilio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de Ciudad Juárez Escuela de Medicina ]]></institution>
<addr-line><![CDATA[Chihuahua ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Juárez de México Servicio de Oftalmología ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<volume>157</volume>
<numero>4</numero>
<fpage>352</fpage>
<lpage>356</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0016-38132021000400352&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0016-38132021000400352&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0016-38132021000400352&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: Los cambios regionales de densidad vascular parafoveal no han sido caracterizados en los pacientes con diabetes tipo 2 sin retinopatía.  Objetivo: Comparar los cambios regionales de densidad vascular entre sujetos sin diabetes (grupo 1) y con diabetes sin retinopatía (grupo 2).  Métodos: Estudio observacional, retrospectivo, transversal y comparativo. La densidad vascular parafoveal por cuadrantes se comparó entre grupos y entre cuadrantes en cada grupo; se correlacionó la densidad de cada cuadrante y la densidad interna, así como la contribución de cada cuadrante a la densidad interna (regresión lineal).  Resultados: Se analizaron 34 ojos en el grupo 1 y 38 en el grupo 2; en este fue menor la densidad vascular interna (20.75 versus 21.85, p = 0.021) y la de los cuadrantes superior (21.05 versus 21.75, p &lt; 0.001) y nasal (20.95 versus 21.50, p = 0.023). En el análisis de regresión, los cuadrantes superior y nasal tuvieron la mayor contribución al cambio en la densidad vascular interna (&#946; = 0.361, &#946; = 0.294) en el grupo 2.  Conclusiones: La densidad vascular interna parafoveal disminuye en los pacientes diabéticos sin retinopatía, a expensas de los cuadrantes superior y nasal, por lo que se requiere evaluación adicional para detectar afecciones microvasculares tempranas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Regional parafoveal vessel density changes have not been characterized in patients with type 2 diabetes without retinopathy.  Objective: To compare regional changes in vessel density between subjects without diabetes (group 1) and with diabetes without retinopathy (group 2).  Methods: Observational, retrospective, cross-sectional, comparative study. Parafoveal vessel density by quadrants was compared between groups and between quadrants in each group; density of each quadrant and inner density were correlated, as well as the contribution of each quadrant to inner density (linear regression).  Results: Thirty four eyes were analyzed in group 1 and 38 in group 2; in the latter, inner vessel density (20.75 vs. 21.85, p = 0.021) and that of superior quadrants (21.05 vs. 21.75, p &lt; 0.001) and nasal quadrants (20.95 vs. 21.50, p = 0.023) were lower. In the regression analysis, superior and nasal quadrants had the largest contribution to the change in inner vessel density in group 2 (&#946; = 0.361 and &#946; = 0.294, respectively).  Conclusions: Parafoveal inner vessel density decreases in diabetic patients without retinopathy at the expense of superior and nasal quadrants, which indicates that further evaluation is required in order for early microvascular disease to be detected.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Densidad vascular parafoveal]]></kwd>
<kwd lng="es"><![CDATA[Diabetes tipo 2]]></kwd>
<kwd lng="es"><![CDATA[Retinopatía diabética]]></kwd>
<kwd lng="es"><![CDATA[Angiografía por tomografía de coherencia óptica]]></kwd>
<kwd lng="en"><![CDATA[Parafoveal vessel density]]></kwd>
<kwd lng="en"><![CDATA[Type 2 diabetes]]></kwd>
<kwd lng="en"><![CDATA[Diabetic retinopathy]]></kwd>
<kwd lng="en"><![CDATA[Optical coherence tomography angiography]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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