<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092022000500265</article-id>
<article-id pub-id-type="doi">10.35366/106507</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Delta de CO2 como predictor de lesión renal aguda (LRA) en pacientes con diagnóstico de síndrome de distrés respiratorio del adulto (SDRA) por COVID-19 y choque séptico]]></article-title>
<article-title xml:lang="en"><![CDATA[CO2 Delta as a predictor of acute kidney injury (AKI) in patients diagnosed with adult respiratory distress syndrome (ARDS) by COVID-19 and septic shock]]></article-title>
<article-title xml:lang="pt"><![CDATA[CO2 delta como preditor de lesão renal aguda (LRA) em pacientes diagnosticados com síndrome do desconforto respiratório do adulto (SDRA) por COVID-19 e choque séptico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villalobos Álvarez]]></surname>
<given-names><![CDATA[Víctor Hugo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Calzada]]></surname>
<given-names><![CDATA[Armando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arcos Zamora]]></surname>
<given-names><![CDATA[Magally]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Varela Sánchez]]></surname>
<given-names><![CDATA[Luis Ernesto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguirre Sánchez]]></surname>
<given-names><![CDATA[Janet Silvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chaires Gutiérrez]]></surname>
<given-names><![CDATA[Rodrigo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Médico ABC  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>36</volume>
<numero>5</numero>
<fpage>265</fpage>
<lpage>271</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092022000500265&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092022000500265&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092022000500265&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  El virus SARS-CoV-2 es capaz de afectar diversos órganos llevándolos a disfunción. Los principales órganos de choque son el pulmón, riñón y sistema cardiovascular. Los pacientes que desarrollan SDRA suelen presentarse con sepsis y choque séptico, siendo más propensos a desarrollar lesión renal aguda (LRA), ya sea por hipovolemia o disfunción miocárdica. El monitoreo invasivo en estos pacientes ha resultado todo un reto, debido a los protocolos sanitarios y a la gran cantidad de pacientes, por lo que la diferencial de CO2 arteriovenosa (DCO2), que es un parámetro fácil de medir, nos puede ayudar a determinar de forma indirecta gasto cardiaco (GC) y perfusión en pacientes con choque.  Objetivo:  Evaluar el uso del DCO2 como un predictor de LRA en pacientes con choque séptico y COVID-19.  Material y métodos:  Se realizó un estudio observacional, transversal y retrolectivo en pacientes con choque séptico y SDRA por COVID-19, ingresados en la unidad de cuidados intensivos (UCI) respiratorios del Centro Médico ABC. Se determinó el DCO2 y su asociación con LRA. Se resumieron los datos usando medidas de tendencia central, t de Student para determinar diferencia de medias y se estimó el riesgo de desarrollar LRA calculando odds ratio (OR). El estudio fue aprobado por el comité de ética de Centro Médico ABC, Ciudad de México (Folio: ABC-21-36).  Resultados:  Del 13 de marzo al 13 de julio de 2020 se admitieron 527 pacientes (p) con diagnóstico de COVID-19, de los cuales 107 (20.3%) presentaron SRDA con requerimiento de ventilación mecánica invasiva (VMI) y 99 (18.78%) choque séptico. De estos pacientes, 74.4% fueron hombres, 61% desarrolló algún grado de LRA, sobre todo en el grupo con DCO2 menor de 6 mmHg (44 versus 17 p &#8804; 0.001) con OR 2.108, IC 95% = 1.23-3.36. No hubo diferencia significativa en las escalas de gravedad.  Conclusión:  DCO2 mayor de 6 mmHg no fue buen predictor para LRA; sin embargo, un DCO2 menor de 6 mmHg aumentó el riesgo de LRA.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  The SARS-CoV-2 virus is capable of affecting various organs, leading to dysfunction. The main organs of shock are the lung, kidney and cardiovascular system. Patients who develop ARDS usually present with sepsis and septic shock, being more prone to developing acute kidney injury (AKI) either due to hypovolemia or myocardial dysfunction. Invasive monitoring in these patients has been a challenge, due to health protocols and the large number of patients, so the arterial-venous CO2 differential (DCO2), is an easy parameter to measure, can help us determine indirectly cardiac output (CO) and perfusion in patients with shock.  Objective:  To assess the use of DCO2 as a predictor of AKI in patients with septic shock and COVID-19.  Material and methods:  An observational, cross-sectional and retrolective study was carried out in patients with septic shock and ARDS due to COVID-19, admitted to the respiratory intensive care unit (ICU) of the ABC Medical Center. DCO2 and its association with LRA were determined. The data was summarized using measures of central tendency, Student&#8217;s t test to determine the difference in means, and the risk of developing AKI was estimated by calculating the Odds Ratio (OR). The study was approved by the ethics committee of Centro Médico ABC, Mexico City (Folio: ABC-21-36).  Results:  From March 13 to July 13, 2020, 527 patients (p) diagnosed with COVID-19 were admitted, 107 (20.3%) presented ARDS with the requirement of invasive mechanical ventilation (IMV) and 99 (18.78%) septic shock, 74.4% were men, 61% developed some degree of AKI, especially in the group with DCO2 less than 6mmHg (44 vs 17 p &#8804; 0.001) with OR 2.108, 95% CI = 1.23-3.36. There was no significant difference in the severity scales.  Conclusion:  DCO2 greater than 6 mmHg was not a good predictor for AKI, however, a DCO2 less than 6mmHg increased the risk of AKI.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  O vírus SARS-CoV-2 é capaz de afetar vários órgãos, levando à disfunção. Os principais órgãos de choque são o pulmão, o rim e o sistema cardiovascular. Os pacientes que desenvolvem SDRA geralmente apresentam sepse e choque séptico, e são mais propensos a desenvolver lesão renal aguda (LRA), seja por hipovolemia ou disfunção miocárdica. O monitoramento invasivo desses pacientes tem sido um desafio devido aos protocolos de saúde e ao grande número de pacientes, de modo que o diferencial arteriovenoso de CO2 (DCO2), que é um parâmetro de fácil mensuração, pode nos ajudar a determinar indiretamente o débito cardíaco (DC) e perfusão em pacientes com choque.  Objetivo:  Avaliar o uso de DCO2 como preditor de LRA em pacientes com choque séptico e COVID-19.  Material e métodos:  Realizou-se um estudo observacional, transversal e retroletivo em pacientes com choque séptico e SDRA por COVID-19, internados na Unidade de Terapia Intensiva (UTI) respiratória do Centro Médico ABC. DCO2 e sua associação com LRA foram determinados. Os dados foram resumidos usando medidas de tendência central, teste t de Student para determinar as diferenças médias e estimou-se o risco de desenvolver LRA calculando o odes ratio (OR). O estudo foi aprovado pelo comitê de ética do Centro Médico ABC, Cidade do México (Folio: ABC-21-36).  Resultados:  De 13 de março a 13 de julho de 2020, foram admitidos 527 pacientes (p) diagnosticados com COVID-19, dos quais 107 (20.3%) apresentaram SDRA com necessidade de ventilação mecânica invasiva (VMI) e 99 (18.78%) choque séptico. 74.4% eram homens, 61% desenvolveram algum grau de LRA, principalmente no grupo com DCO2 menor que 6 mmHg (44 vs 17 p &#8804; 0.001) com OR 2.108, IC 95% = 1.23-3.36. Não houve diferença significativa nas escalas de gravidade.  Conclusão:  DCO2 maior que 6 mmHg não foi um bom preditor para LRA; entretanto, uma DCO2 menor que 6 mmHg aumentou o risco de LRA.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Lesión renal aguda]]></kwd>
<kwd lng="es"><![CDATA[delta CO2]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[SDRA]]></kwd>
<kwd lng="es"><![CDATA[choque séptico]]></kwd>
<kwd lng="en"><![CDATA[Acute kidney injury]]></kwd>
<kwd lng="en"><![CDATA[delta CO2]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[ARDS]]></kwd>
<kwd lng="en"><![CDATA[septic shock]]></kwd>
<kwd lng="pt"><![CDATA[Lesão renal aguda]]></kwd>
<kwd lng="pt"><![CDATA[delta CO2]]></kwd>
<kwd lng="pt"><![CDATA[COVID-19]]></kwd>
<kwd lng="pt"><![CDATA[SDRA]]></kwd>
<kwd lng="pt"><![CDATA[choque séptico]]></kwd>
</kwd-group>
</article-meta>
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