<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-5044</journal-id>
<journal-title><![CDATA[Revista mexicana de neurociencia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. neurocienc.]]></abbrev-journal-title>
<issn>1665-5044</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Neurología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-50442026000200072</article-id>
<article-id pub-id-type="doi">10.24875/rmn.25000040</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Hematologic data predict survival in Mexican Mestizo people with Creutzfeldt-Jakob disease]]></article-title>
<article-title xml:lang="es"><![CDATA[Los datos hematológicos predicen la supervivencia en mestizos mexicanos con enfermedad de Creutzfeldt-Jakob]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz-López]]></surname>
<given-names><![CDATA[Fabricio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez-García]]></surname>
<given-names><![CDATA[Miguel A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yescas-Gómez]]></surname>
<given-names><![CDATA[Petra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes-Terán]]></surname>
<given-names><![CDATA[Gustavo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valdés-Ferrer]]></surname>
<given-names><![CDATA[Sergio I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A8"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Benemérita Universidad Autónoma de Puebla, Heroica Puebla de Zaragoza School of Medicine ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez Departamento de Genética ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Departamento de Neurología y Psiquiatría ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Puebla  ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Dirección Médica ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Gobierno de México Secretaría de Salud ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af8">
<institution><![CDATA[,Instituto Tecnológico y de Estudios Superiores de Monterrey Escuela de Medicina y Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2026</year>
</pub-date>
<volume>27</volume>
<numero>2</numero>
<fpage>72</fpage>
<lpage>77</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-50442026000200072&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-50442026000200072&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-50442026000200072&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective Creutzfeldt-Jakob disease (CJD) is a rare cause of rapidly progressive dementia due to the accumulation of misfolded prion proteins (PrPC) in the brain. Mortality is essentially universal within months to a few years after symptom onset. Here, we evaluated biomarkers derived from baseline complete blood counts (CBCs) in search of readily available predictors of disease progression using survival span as an outcome.  Methods We analyzed retrospective data derived from the baseline CBC from Mexican Mestizo individuals. We performed Spearman rho correlation to determine the association between survival time from disease onset with leukocyte and erythrocyte counts of people with CJD. We used Cox proportional hazard models to predict survival time, and log-rank tests to compare survival of subgroups.  Results We included 22 people with probable or definite CJD. Twelve (55%) were female. The mean age at diagnosis was 55 years (interquartile range: 25-85). Lower hemoglobin (r = -0.494, p = 0.019), hematocrit (r = -0.445, p = 0.037), and lymphocyte (r = -0.421, p = 0.050; log-rank test: &#967;2 = 3.7, p = 0.05) counts and higher neutrophils (r = 0.404, p = 0.061; log-rank test: &#967;2 = 5.7, p = 0.02) were associated with longer survival time.  Conclusions In the present study, we observed that common hematological values derived from a CBC were associated with survival span in people living with CJD. Those values support previous observations suggesting that the circulating availability of wild-type prion protein in blood cells is a limiting factor in the production of misfolded prion protein.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo La enfermedad de Creutzfeldt-Jakob (ECJ) es una causa de demencia de rápida progresión debido a la acumulación de proteínas priónicas cerebrlaes mal plegadas. La mortalidad es prácticamente universal en un plazo de meses a pocos años tras el inicio de los síntomas. En este estudio evaluamos biomarcadores derivados de la biometría hemática (BH) basal buscando de predictores accesibles de progresión de ECJ, utilizando la supervivencia como desenlace.  Métodos Analizamos datos retrospectivos derivados de BH basal de individuos mestizos mexicanos con ECJ. Realizamos una correlación rho de Spearman para determinar la asociación entre la supervivencia desde el inicio de síntomas y los recuentos de leucocitos y eritrocitos. Utilizamos modelos de riesgos proporcionales de Cox para predecir el tiempo de supervivencia y pruebas de log-rank para comparar la supervivencia de los subgrupos.  Resultados Incluimos a 22 personas con ECJ probable o confirmada. Doce (55%) eran mujeres. La edad media al momento del diagnóstico fue de 55 años (RIC: 25-85). Un recuento bajo de hemoglobina (r = -0.494, p = 0.019), hematocrito (r = -0.445, p = 0.037) y linfocitos (r = -0.421, p = 0.050; prueba log-rank: &#967;2 = 3.7, p = 0.05) y un recuento elevado de neutrófilos (r = 0.404, p = 0.061; prueba log-rank: &#967;2 = 5.7, p = 0.02) se asociaron con una mayor supervivencia.  Conclusiones En el presente estudio observamos que los valores hematológicos comunes obtenidos a partir de la BH se asociaron con la supervivencia en personas con ECJ. Estos valores respaldan observaciones previas que sugieren que la disponibilidad circulante de la proteína priónica silvestre en las células sanguíneas puede ser un factor limitante en la producción de proteínas priónicas mal plegadas.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Creutzfeldt-Jakob disease]]></kwd>
<kwd lng="en"><![CDATA[Complete blood counts]]></kwd>
<kwd lng="en"><![CDATA[Prion disease]]></kwd>
<kwd lng="en"><![CDATA[Survival time]]></kwd>
<kwd lng="en"><![CDATA[Biomarkers]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad de Creutzfeldt-Jakob]]></kwd>
<kwd lng="es"><![CDATA[Hemograma completo]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad priónica]]></kwd>
<kwd lng="es"><![CDATA[Tiempo de supervivencia]]></kwd>
<kwd lng="es"><![CDATA[Biomarcadores]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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