<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-5044</journal-id>
<journal-title><![CDATA[Revista mexicana de neurociencia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. neurocienc.]]></abbrev-journal-title>
<issn>1665-5044</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Neurología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-50442022000100014</article-id>
<article-id pub-id-type="doi">10.24875/rmn.21000018</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Parkinson&#8217;s disease in the state of Michoacan, evolution, and treatment]]></article-title>
<article-title xml:lang="es"><![CDATA[Enfermedad de Parkinson en el estado de Michoacán, evolución y tratamiento]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Villa]]></surname>
<given-names><![CDATA[Marcela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leal-Cantú]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Madrigal-Salas]]></surname>
<given-names><![CDATA[Rosa G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Leyva]]></surname>
<given-names><![CDATA[Ildefonso]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quintana-Díaz]]></surname>
<given-names><![CDATA[Mariana A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gonzalez-García]]></surname>
<given-names><![CDATA[Conne L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Star Médica Clinical Neurology Service ]]></institution>
<addr-line><![CDATA[Morelia Michoacán]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital General &#8220;Dr. Miguel Silva,&#8221; Neurology Department ]]></institution>
<addr-line><![CDATA[Morelia Michoacán]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Central &#8220;Dr. Ignacio Morones Prieto&#8221; Neurology Department ]]></institution>
<addr-line><![CDATA[San Luis Potosí ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Autónoma de San Luis Potosí Medicine School ]]></institution>
<addr-line><![CDATA[San Luis Potosí ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto Tecnológico de Estudios Superiores de Monterrey Medicine and Health Scinence School ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Hospital General &#8220;Dr. Miguel Silva,&#8221; Clinical Research Unity ]]></institution>
<addr-line><![CDATA[Morelia Michoacán]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2022</year>
</pub-date>
<volume>23</volume>
<numero>1</numero>
<fpage>14</fpage>
<lpage>21</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-50442022000100014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-50442022000100014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-50442022000100014&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective: This work is the first registry focused on knowing patients&#8217; characteristics with Parkinson&#8217;s disease (PD), evolution and treatment used in the state of Michoacán.  Methods: 68 patients with PD from the neurology consultation of the General Hospital &#8220;Dr. Miguel Silva&#8221; from October 1, 2019, to December 31, 2019, who fulfilled the UKPDSBB criteria, were studied. Sociodemographic data, disease duration, and severity according to the Unified Parkinson&#8217;s Disease Rating Scale (MDS-UPDRS) and Hoehn and Yahr Scale were collected.  Results: A total of 68 patients were included in the study. Seven of them were eliminated for not meeting the inclusion criteria. Of the 61 evaluated, 31 (50.8%) were women, the mean age was 68 years (± 9.8) and the age of diagnosis was 61 years (± 12.6). The predominant comorbidities were diabetes mellitus (16.4%), systemic arterial hypertension (44.3%), and depression (70.5%). The dominant phenotype was rigid-akinetic, with absence or slight tremor in 50.8%. About 36.1% had between 5 and 10 years of suffering from the disease. 36.1% had exposure to pesticides; 31.1% had a history of head trauma. There were 24.6% smoking and 31.1% alcoholism. The drugs most used for motor manifestations were levodopa/carbidopa in 83.6% and pramipexole in 31.1 %. In part I of the MDS-UPDRS scale, the mean score was 9.8 ± 6.0; part II 14.37 ± 9.6; part III 21.22 ± 12.4 and part IV 3.2 ± 3.69. HY, I occupied 37.7%; II 26.2%; III 23%; IV 9.8% and V 3.3%.  Conclusions: In this population, the disease occurred without distinction of gender. The only treatment was pharmacological. Rehabilitation, the support of the psychiatrist and nutritionists, is essential for comprehensive management.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo: Este trabajo es el primer registro enfocado en conocer las características, evolución y tratamiento de los pacientes con enfermedad de Parkinson (EP) utilizados en el estado de Michoacán.  Material y métodos: Se estudiaron 68 pacientes con EP de la consulta de neurología del Hospital General &#8220;Dr. Miguel Silva&#8221; del 1 de octubre de 2019 al 31 de diciembre de 2019, que cumplieran con los criterios de la UKPDSBB. Se recogieron datos sociodemográficos, duración y gravedad de la enfermedad según la Escala Unificada de Calificación de la Enfermedad de Parkinson (MDS-UPDRS) y la Escala de Hoehn y Yahr.  Resultados: Se incluyó a un total de 68 pacientes. Siete de ellos fueron eliminados por no cumplir con los criterios de inclusión. De los 61 evaluados, 31 (50.8%) eran mujeres, la edad media fue de 68 años ± 9.8 años y la edad de diagnóstico fue de 61 años ± 12.6. Las comorbilidades predominantes fueron diabetes mellitus (16.4%), hipertensión arterial sistémica (44.3%) y depresión (70.5%). El fenotipo dominante fue rígido-acinético, con ausencia o leve temblor en el 50.8%. El 36.1% tenía entre 5 y 10 años de padecer la enfermedad. 36.1% tuvo exposición a plaguicidas y 31.1% tenía antecedentes de traumatismo craneoencefálico. Los fármacos más utilizados para las manifestaciones motoras fueron levodopa/carbidopa en el 83.6% y pramipexol en 31.1%. En la parte I de la escala MDS-UPDRS, la puntuación media fue de 9.8 ± 6,0; parte II, 14.37 ± 9.6; parte III 21.22 ± 12.4 y en la parte IV 3.2 ± 3.69. HY, I ocupó 37.5%; II 26.2%; III 23%; IV 9.8% y V 3.3%.  Conclusiones: En esta población la enfermedad se presentó sin distinción de género. El único tratamiento fue farmacológico. La rehabilitación, el apoyo del psiquiatra y nutriología se hacen indispensables para el manejo integral.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Parkinson&#8217;s disease]]></kwd>
<kwd lng="en"><![CDATA[Mexico]]></kwd>
<kwd lng="en"><![CDATA[Cross-sectional study]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad de Parkinson]]></kwd>
<kwd lng="es"><![CDATA[México]]></kwd>
<kwd lng="es"><![CDATA[Estudio transversal]]></kwd>
</kwd-group>
</article-meta>
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