<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-1146</journal-id>
<journal-title><![CDATA[Boletín médico del Hospital Infantil de México]]></journal-title>
<abbrev-journal-title><![CDATA[Bol. Med. Hosp. Infant. Mex.]]></abbrev-journal-title>
<issn>1665-1146</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-11462016000600467</article-id>
<article-id pub-id-type="doi">10.1016/j.bmhimx.2016.11.005</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Medical interventions for cancer treatment-induced symptoms in children: an overview]]></article-title>
<article-title xml:lang="es"><![CDATA[Intervenciones médicas para los síntomas inducidos por el tratamiento en niños con cáncer: una perspectiva general]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barajas-Nava]]></surname>
<given-names><![CDATA[Leticia A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garduño-Espinosa]]></surname>
<given-names><![CDATA[Juan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Hospital Infantil de México Federico Gómez Unidad de Investigación de Medicina Basada en Evidencias ]]></institution>
<addr-line><![CDATA[ Mexico City]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="A02">
<institution><![CDATA[,Hospital Infantil de México Federico Gómez Dirección de Investigación ]]></institution>
<addr-line><![CDATA[ Mexico City]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>73</volume>
<numero>6</numero>
<fpage>467</fpage>
<lpage>483</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-11462016000600467&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-11462016000600467&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-11462016000600467&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Background: Childhood cancer accounts for 0.5 to 4.6% of the total number of cases in any population. According to the treatment, some side effects are present. Most adverse reactions can cause severe consequences for the survival of the patient. The more effective interventions for the management and the prevention of treatment-induced symptoms (TIS) in children with cancer are necessary to know. The objective of this review was to identify and describe available scientific evidence on the efficacy and safety of interventions used for the management and prevention of TIS in children with cancer.  Methods: We conducted a systematic review of the literature on studies that evaluated or described the effectiveness of interventions used for the management and prevention of TIS in children with cancer in some of the major electronic databases. Results were qualitative synthesized and presented as evidence tables.  Results: We identified eight systematic reviews. The revisions included experimental studies. All participants, including children and adults, were patients diagnosed with some cancer about to receive or that received treatment.  Conclusions: The results showed only a reduced number of clinical trials that have evaluated the interventions for the management of TIS in children with cancer. In addition, the available evidence was limited and of poor quality. It is necessary to conduct more clinical trials with good methodological quality and high statistical power.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción: El cáncer en la infancia representa del 0.5 al 4.6% del total de casos en una población. Dependiendo del tratamiento se presentan cierto tipo de efectos secundarios. La mayoría de los eventos adversos provocan consecuencias graves para la supervivencia del paciente. Es importante conocer cuáles son las intervenciones más eficaces para el manejo y la prevención de los síntomas inducidos por el tratamiento (SIT) en niños con cáncer. El objetivo de esta revisión fue identificar y describir la evidencia científica disponible sobre la eficacia y seguridad de las intervenciones utilizadas para el manejo y la prevención de los SIT en niños con cáncer.  Métodos: Se realizaron búsquedas bibliográficas en las principales bases de datos electrónicas para identificar revisiones sistemáticas que evaluaran o describieran la efectividad de las intervenciones utilizadas para el manejo y la prevención de los SIT en niños con cáncer. Se realizó la síntesis cualitativa de los resultados, que se presentaron mediante tablas de evidencia.  Resultados: Se identificaron ocho revisiones sistemáticas. Las revisiones incluyeron estudios experimentales; los participantes de los estudios, incluyendo niños y adultos, fueron pacientes diagnosticados con algún tipo de cáncer a punto de recibir o que recibieron tratamiento.  Conclusiones: Los resultados demuestran que un número reducido de ensayos clínicos han evaluado las intervenciones para el manejo de SIT en niños con cáncer. Además, la evidencia existente es limitada y de baja calidad. Existe la necesidad de realizar ensayos clínicos con mayor poder estadístico y adecuada calidad metodológica.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cáncer]]></kwd>
<kwd lng="es"><![CDATA[Intervenciones médicas]]></kwd>
<kwd lng="es"><![CDATA[Síntomas inducidos]]></kwd>
<kwd lng="es"><![CDATA[Niños]]></kwd>
<kwd lng="es"><![CDATA[Eficacia]]></kwd>
<kwd lng="es"><![CDATA[Revisión sistemática]]></kwd>
<kwd lng="en"><![CDATA[Cancer]]></kwd>
<kwd lng="en"><![CDATA[Medical interventions]]></kwd>
<kwd lng="en"><![CDATA[Induced symptoms]]></kwd>
<kwd lng="en"><![CDATA[Children]]></kwd>
<kwd lng="en"><![CDATA[Efficacy]]></kwd>
<kwd lng="en"><![CDATA[Systematic review]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stewart]]></surname>
<given-names><![CDATA[BW]]></given-names>
</name>
<name>
<surname><![CDATA[Wild]]></surname>
<given-names><![CDATA[CP]]></given-names>
</name>
</person-group>
<collab>World Health Organization (WHO)</collab>
<collab>International Agency for Research on Cancer (IARC)</collab>
<source><![CDATA[World Cancer Report 2014]]></source>
<year>2014</year>
<publisher-loc><![CDATA[Lyon, France ]]></publisher-loc>
<publisher-name><![CDATA[IARC Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saracci]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Wild]]></surname>
<given-names><![CDATA[C.P.]]></given-names>
</name>
</person-group>
<source><![CDATA[International Agency for Research on Cancer: The first 50 years, 1965-2015. World Health Organization (WHO)]]></source>
<year>2015</year>
<publisher-loc><![CDATA[Lyon, France ]]></publisher-loc>
<publisher-name><![CDATA[WHO Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="">
<collab>International Agency for Research on Cancer (IARC)</collab>
<collab>World Health Organization (WHO)</collab>
<source><![CDATA[GLOBOCAN 2012: Estimated Cancer and Incidence, Mortality Prevalence Worldwide in 2012]]></source>
<year>2016</year>
<publisher-loc><![CDATA[Lyon, France ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="">
<collab>World Health Organization (WHO)</collab>
<source><![CDATA[Cancer. International Childhood Cancer Day: Questions &amp; Answers]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="">
<source><![CDATA[Childhood Cancer International (CCI)]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="">
<collab>International Society of Paediatric Oncology (SIOP)</collab>
<source><![CDATA[Childhood cancer advocacy]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="">
<source><![CDATA[National Cancer Institute (NIH)]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sonis]]></surname>
<given-names><![CDATA[S.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Elting]]></surname>
<given-names><![CDATA[L.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Keefe]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Peterson]]></surname>
<given-names><![CDATA[D.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Schubert]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Hauer-Jensen]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cancer]]></source>
<year>2004</year>
<volume>100</volume>
<page-range>1995-2025</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van Dalen]]></surname>
<given-names><![CDATA[E.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Raphaël]]></surname>
<given-names><![CDATA[M.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Caron]]></surname>
<given-names><![CDATA[H.N.]]></given-names>
</name>
<name>
<surname><![CDATA[Kremer]]></surname>
<given-names><![CDATA[L.C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2014</year>
</nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Management of febrile neutropenia: ESMO Clinical Practice Guidelines]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Naurois]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Novitzky-Basso]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Gill]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Marti]]></surname>
<given-names><![CDATA[F.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Cullen]]></surname>
<given-names><![CDATA[M.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Roila]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<collab>ESMO Guidelines Working Group</collab>
<source><![CDATA[Ann Oncol]]></source>
<year>2010</year>
<volume>21</volume>
<page-range>v252-6</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Acute and delayed nausea and emesis control in pediatric oncology patients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Holdsworth]]></surname>
<given-names><![CDATA[M.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Raisch]]></surname>
<given-names><![CDATA[D.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Frost]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cancer]]></source>
<year>2006</year>
<volume>106</volume>
<page-range>931-40</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A multidisciplinary review of nutrition considerations in the pediatric oncology population: a perspective from children's oncology group]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ladas]]></surname>
<given-names><![CDATA[E.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Sacks]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Meacham]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Henry]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Enriquez]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Lowry]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<source><![CDATA[Nutr Clin Pract]]></source>
<year>2005</year>
<volume>20</volume>
<page-range>377-93</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Systematic reviews: synthesis of best evidence for clinical decisions]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cook]]></surname>
<given-names><![CDATA[D.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Mulrow]]></surname>
<given-names><![CDATA[C.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Haynes]]></surname>
<given-names><![CDATA[R.B.]]></given-names>
</name>
</person-group>
<source><![CDATA[Ann Intern Med]]></source>
<year>1997</year>
<volume>126</volume>
<page-range>376-80</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Higgins]]></surname>
<given-names><![CDATA[JPT]]></given-names>
</name>
<name>
<surname><![CDATA[Green]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0]]></source>
<year>2011</year>
<publisher-name><![CDATA[The Cochrane Collaboration]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cheuk]]></surname>
<given-names><![CDATA[D.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Sieswerda]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[van Dalen]]></surname>
<given-names><![CDATA[E.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Postma]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Kremer]]></surname>
<given-names><![CDATA[L.C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Colony-stimulating factors for prevention and treatment of infectious complications in patients with acute myelogenous leukemia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gurion]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Belnik-Plitman]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Gafter-Gvili]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Paul]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Vidal]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Ben-Bassat]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2011</year>
</nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Colony-stimulating factors for chemotherapy-induced febrile neutropenia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mhaskar]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Clark]]></surname>
<given-names><![CDATA[O.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Lyman]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Engel Ayer Botrel]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Morganti Paladini]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Djulbegovic]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2014</year>
</nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Antiemetic medication for prevention and treatment of chemotherapy-induced nausea and vomiting in childhood]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Phillips]]></surname>
<given-names><![CDATA[R.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Friend]]></surname>
<given-names><![CDATA[A.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Gibson]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Houghton]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Gopaul]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Craig]]></surname>
<given-names><![CDATA[J.V.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cochrane Database Syst Rev.]]></source>
<year>2016</year>
<volume>2</volume>
</nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Riley]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Glenny]]></surname>
<given-names><![CDATA[A.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Worthington]]></surname>
<given-names><![CDATA[H.V.]]></given-names>
</name>
<name>
<surname><![CDATA[Littlewood]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Clarkson]]></surname>
<given-names><![CDATA[J.E.]]></given-names>
</name>
<name>
<surname><![CDATA[McCabe]]></surname>
<given-names><![CDATA[M.G.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2015</year>
</nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Colony-stimulating factors for prevention of myelosuppressive therapy-induced febrile neutropenia in children with acute lymphoblastic leukaemia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sasse]]></surname>
<given-names><![CDATA[E.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Sasse]]></surname>
<given-names><![CDATA[A.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Brandalise]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Clark]]></surname>
<given-names><![CDATA[O.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Richards]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2005</year>
</nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Medical interventions for the prevention of platinum-induced hearing loss in children with cancer]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van As]]></surname>
<given-names><![CDATA[J.W.]]></given-names>
</name>
<name>
<surname><![CDATA[van den Berg]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[van Dalen]]></surname>
<given-names><![CDATA[E.C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cochrane Database Syst Rev.]]></source>
<year>2012</year>
</nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Nutritional support in children and young people with cancer undergoing chemotherapy]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ward]]></surname>
<given-names><![CDATA[E.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Henry]]></surname>
<given-names><![CDATA[L.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Friend]]></surname>
<given-names><![CDATA[A.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Wilkins]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Phillips]]></surname>
<given-names><![CDATA[R.S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cochrane Database Syst Rev.]]></source>
<year>2015</year>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
