<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-888X</journal-id>
<journal-title><![CDATA[TIP. Revista especializada en ciencias químico-biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[TIP]]></abbrev-journal-title>
<issn>1405-888X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Zaragoza]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-888X2006000200078</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Mecanismos moleculares que controlan el desarrollo de la extremidad de los vertebrados]]></article-title>
<article-title xml:lang="en"><![CDATA[Molecular mechanisms that controls vertebrate limb development]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Abarca-Buis]]></surname>
<given-names><![CDATA[René Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garciadiego-Cázares]]></surname>
<given-names><![CDATA[David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chimal-Monroy]]></surname>
<given-names><![CDATA[Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UNAM Instituto de Investigaciones Biomédicas Depto. de Biología Celular y Fisiología]]></institution>
<addr-line><![CDATA[México, D.F ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2006</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2006</year>
</pub-date>
<volume>9</volume>
<numero>2</numero>
<fpage>78</fpage>
<lpage>89</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-888X2006000200078&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-888X2006000200078&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-888X2006000200078&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen ¿Cómo un grupo de células indiferenciadas pueden formar estructuras y tejidos altamente organizados y diferenciados?, ¿Cuál es la naturaleza de las señales que dictan estos eventos? ¿Cómo son los procesos del desarrollo que actúan para que las diferentes especies desarrollen estructuras similares pero adaptadas al medio en el que viven? Uno de los modelos que han permitido responder en parte a estas interrogantes es la extremidad embrionaria. A partir de los estudios en la extremidad embrionaria se han propuesto una serie de interesantes paradigmas que han cambiado la percepción de ver a los procesos del desarrollo como aislados y poco dinámicos. En esta revisión, destacamos aquellos estudios que han contribuido de manera amplia a entender la inducción de la formación de la extremidad y el establecimiento de los centros organizadores que controlan su morfogénesis, así como el patrón esquelético que incluye la diferenciación del cartílago y la muerte celular.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract How can a group of undifferentiated cells develop into complex structures and highly organized and differentiated tissues? What is the nature of the signals that dictate these events? Which developmental processes act so that different species can develop similar structures adapted to the environment where they live? A model that partly answers these questions is the embryonic limb. Limb bud studies have suggested interesting paradigms that have changed the perception of development as an isolated and not very dynamic process. The present work reviews the studies that have led to understand the induction of the limb bud and the establishment of the organizing centers that control limb morphogenesis, as well as the skeletal pattern that includes cartilage differentiation and cell death.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[AER]]></kwd>
<kwd lng="es"><![CDATA[condrogénesis]]></kwd>
<kwd lng="es"><![CDATA[extremidad embrionaria]]></kwd>
<kwd lng="es"><![CDATA[identidad de los dedos]]></kwd>
<kwd lng="es"><![CDATA[identidad de la extremidad]]></kwd>
<kwd lng="es"><![CDATA[muerte celular programada]]></kwd>
<kwd lng="es"><![CDATA[zona de progreso]]></kwd>
<kwd lng="es"><![CDATA[ZPA]]></kwd>
<kwd lng="en"><![CDATA[AER]]></kwd>
<kwd lng="en"><![CDATA[chondrogenesis]]></kwd>
<kwd lng="en"><![CDATA[limb bud]]></kwd>
<kwd lng="en"><![CDATA[digit identity]]></kwd>
<kwd lng="en"><![CDATA[limb identity]]></kwd>
<kwd lng="en"><![CDATA[programmed cell death]]></kwd>
<kwd lng="en"><![CDATA[progress zone]]></kwd>
<kwd lng="en"><![CDATA[ZPA]]></kwd>
</kwd-group>
</article-meta>
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