<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2954-4122</journal-id>
<journal-title><![CDATA[Archivos de neurociencias (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Arch. Neurocien. (Mex.)]]></abbrev-journal-title>
<issn>2954-4122</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez"]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2954-41222025000100044</article-id>
<article-id pub-id-type="doi">10.24875/anc.m24000031</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Hemorragia intracerebral asociada al uso de sildenafilo: reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Intracerebral hemorrhage associated with use of sildenafil: case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rico-Hernández]]></surname>
<given-names><![CDATA[Hugo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cano-Nigenda]]></surname>
<given-names><![CDATA[Vanessa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Huamaní-Saldaña]]></surname>
<given-names><![CDATA[Charles A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arauz]]></surname>
<given-names><![CDATA[Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mercado-Pompa]]></surname>
<given-names><![CDATA[Andrés A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Departamento de Farmacología Facultad de Medicina]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez Clínica de Enfermedad Vascular Cerebral ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<volume>30</volume>
<numero>1</numero>
<fpage>44</fpage>
<lpage>47</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2954-41222025000100044&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2954-41222025000100044&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2954-41222025000100044&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La hemorragia intracerebral es el resultado de la degeneración en las arteriolas penetrantes del parénquima cerebral. Este trabajo presenta el caso de un hombre de 47 años cuyo ictus hemorrágico presentaba una relación temporal directa con el consumo de sildenafilo. Se realizó tomografía computarizada de cráneo que corroboró la hemorragia ubicada en el parénquima cerebeloso con predominio vermiano y en el hemisferio izquierdo. La hemorragia intracerebral asociada al consumo de sildenafilo es un fenómeno muy poco frecuente cuya relación solo puede inferirse una vez descartadas las causas más frecuentes, tales como hipertensión, angiopatía amiloide cerebral y aneurismas. Sin embargo, solo puede catalogarse como agente causal si su consumo se realizó dentro de las 2 horas previas a la aparición de los síntomas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Intracerebral hemorrhage is the result of degeneration in penetrating arterioles of the brain parenchyma. This work presents the case of a 47-year-old man, whose hemorrhagic stroke has a direct temporal relationship with the consumption of sildenafil. A computed tomography of the skull was performed, corroborating the hemorrhage located in the cerebellar parenchyma, predominantly vermian and in the left hemisphere. Intracerebral hemorrhage associated with the use of sildenafil is a very rare phenomenon which its relationship can only be inferred once the most frequent causes such as hypertension, cerebral amyloid angiopathy or aneurysms have been ruled out. However, it could only be classified as a causative agent if it was consumed within the 2 hours prior to the onset of symptoms.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Hemorragia intracerebral]]></kwd>
<kwd lng="es"><![CDATA[Citrato de sildenafilo]]></kwd>
<kwd lng="es"><![CDATA[Inhibidor de la fosfodiesterasa 5]]></kwd>
<kwd lng="es"><![CDATA[Reacción adversa]]></kwd>
<kwd lng="es"><![CDATA[Microangiopatía hipertensiva]]></kwd>
<kwd lng="en"><![CDATA[Intracerebral hemorrhage]]></kwd>
<kwd lng="en"><![CDATA[Sildenafil citrate]]></kwd>
<kwd lng="en"><![CDATA[Phosphodiesterase 5 inhibitor]]></kwd>
<kwd lng="en"><![CDATA[Adverse reaction]]></kwd>
<kwd lng="en"><![CDATA[Hypertensive microangiopathy]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Caplan]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Stroke:etiology, classification, and epidemiology]]></article-title>
<source><![CDATA[UpToDate]]></source>
<year>2022</year>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rordorf]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[McDonald]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spontaneous intracerebral hemorrhage:pathogenesis, clinical features, and diagnosis]]></article-title>
<source><![CDATA[UpToDate]]></source>
<year>2023</year>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Snyder]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&gt;Androgens and the male reproductive tract]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Brunton]]></surname>
<given-names><![CDATA[LL]]></given-names>
</name>
<name>
<surname><![CDATA[Hilal-Dandan]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Knollmann]]></surname>
<given-names><![CDATA[BC]]></given-names>
</name>
</person-group>
<source><![CDATA[Goodman &amp;Gilman's:The Pharmacological Basis of Therapeutics]]></source>
<year>2017</year>
<edition>13th ed</edition>
<page-range>840</page-range><publisher-loc><![CDATA[New York, NY ]]></publisher-loc>
<publisher-name><![CDATA[McGraw-Hill]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="">
<source><![CDATA[Drug Result Page - Sildenafil Citrate - Dosing/Administration - FDA Uses]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lucchese]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Dhaliwal]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[Kaur]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Qi]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A case of recurrent lobar intracerebral hemorrhage in the setting of phosphodiesterase-5 inhibitor use]]></article-title>
<source><![CDATA[Missouri Medicine]]></source>
<year>2019</year>
<volume>116</volume>
<page-range>400</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Buxton]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Flannery]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Wild]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Bassi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sildenafil (Viagra)-induced spontaneous intracerebral haemorrhage]]></article-title>
<source><![CDATA[Br J Neurosurg]]></source>
<year>2001</year>
<volume>15</volume>
<page-range>347-9</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Samada]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Shiraishi]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Aoyagi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Momoi]]></surname>
<given-names><![CDATA[MY]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cerebral hemorrhage associated with sildenafil (Revatio) in an infant]]></article-title>
<source><![CDATA[Pediatr Cardiol]]></source>
<year>2009</year>
<volume>30</volume>
<page-range>998-9</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alpsan]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
<name>
<surname><![CDATA[Bebek]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Ciftci]]></surname>
<given-names><![CDATA[FD]]></given-names>
</name>
<name>
<surname><![CDATA[Coban]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Bahar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Tuncay]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intracerebral hemorrhage associated with sildenafil use:a case report]]></article-title>
<source><![CDATA[J Neurol]]></source>
<year>2008</year>
<volume>255</volume>
<page-range>932-3</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pharmacokinetics, efficacy, and safety of selective inhibitors of phosphodiesterase type 5 and sublingual apomorphine for the treatment of erectile dysfunction]]></article-title>
<source><![CDATA[Korean J Androl]]></source>
<year>2002</year>
<volume>20</volume>
<page-range>113-25</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
