<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2594-2166</journal-id>
<journal-title><![CDATA[Medicina y ética]]></journal-title>
<abbrev-journal-title><![CDATA[Med. ética]]></abbrev-journal-title>
<issn>2594-2166</issn>
<publisher>
<publisher-name><![CDATA[Universidad Anáhuac México, Facultad de Bioética]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2594-21662018000401181</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Editing genético (edición genética): ¿nueva cuestión bioética?]]></article-title>
<article-title xml:lang="en"><![CDATA[Gene editing: a new issue for bioethics?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Refolo]]></surname>
<given-names><![CDATA[Pietro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pascali]]></surname>
<given-names><![CDATA[Vincenzo L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Spagnolo]]></surname>
<given-names><![CDATA[Antonio G.]]></given-names>
</name>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Católica del Sacro Cuore Facultad de Medicina y Cirugía &#8220;A. Gemelli&#8221; Instituto de Bioética y Humanidades Médicas]]></institution>
<addr-line><![CDATA[Roma ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Università Cattolica del Sacro Cuore Facultad de Medicina y Cirugía &#8220;A. Gemelli&#8221; Instituto de Salud Pública]]></institution>
<addr-line><![CDATA[Roma ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>29</volume>
<numero>4</numero>
<fpage>1181</fpage>
<lpage>1223</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2594-21662018000401181&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2594-21662018000401181&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2594-21662018000401181&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Modificaciones controladas en el genoma son posibles, por medio de diversas técnicas, desde los años 70. Nucleasa con dedo de zinc, nucleasa TALE, pero sobre todo CRISPR-Cas9 son técnicas de editing genético (edición genética) que han hecho más simple efectuarlas. El sistema CRISPR-Cas9, en particular, se está demostrando extremadamente ventajoso en términos de accesibilidad, eficiencia y versatilidad. Los objetivos de la presente contribución consisten en: 1. reconstruir los &#8220;hechos&#8221; sobresalientes que han determinado el surgimiento del tópico del &#8220;editing genético (edición genética)&#8221;; 2. intentar dar una respuesta a un primer y fundamental interrogante acerca de la originalidad de los dilemas éticos suscitados por aquél con particular referencia al CRISPR-Cas9. La conclusión es que, en la situación actual, el uso de estas nuevas técnicas no suscita cuestiones éticas nuevas. La única excepción parecería estar dada por el particular tipo de mutaciones inducidas por estas técnicas, inconfundibles a largo plazo de aquéllas producidas por la naturaleza, hecho que está ya determinando algunas dificultades en la clasificación de los OGM obtenidos por medio de estas técnicas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Controlled genome mutations are made possible through several techniques since the &#8217;70s. Zinc finger nucleases, TALE nucleases and above all CRISPR-Cas9 system are &#8220;gene editing&#8221; techniques which have made mutations easier. Particularly, CRISPR-Cas9 system seems to be extremely profitable in terms of accessibility, efficiency and versatility. The aims of the present article are: 1. to reconstruct the main &#8220;facts&#8221; about the birth of the topic on &#8220;gene editing&#8221;; to seek to answer a first question about the novelty of issues raised by this topic. Our conclusion is that, from an ethical point of view, using these techniques does not raise new ethical questions. Perhaps, the only exception refers to the specific mutations produced through these techniques which cannot be distinguished from natural mutations and makes GMO classification more difficult.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[CRISPR-Cas9]]></kwd>
<kwd lng="es"><![CDATA[editing genético]]></kwd>
<kwd lng="es"><![CDATA[ingeniería genética]]></kwd>
<kwd lng="en"><![CDATA[CRISPR-Cas9]]></kwd>
<kwd lng="en"><![CDATA[gene editing]]></kwd>
<kwd lng="en"><![CDATA[genetic engineering]]></kwd>
</kwd-group>
</article-meta>
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