<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902017000400487</article-id>
<article-id pub-id-type="doi">10.29262/ram.v64i4.281</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Dermatitis atópica severa e hiper-IgE]]></article-title>
<article-title xml:lang="en"><![CDATA[Severe atopic dermatitis and hiper-IgE]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cid del Prado-Izquierdo]]></surname>
<given-names><![CDATA[María de la Luz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zarco-Cid del Prado]]></surname>
<given-names><![CDATA[Osvaldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Visoso-Salgado]]></surname>
<given-names><![CDATA[Ángel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Clínica de Asma, Alergia e Inmunología  ]]></institution>
<addr-line><![CDATA[Toluca Estado de México]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>64</volume>
<numero>4</numero>
<fpage>487</fpage>
<lpage>492</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902017000400487&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902017000400487&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902017000400487&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: la dermatitis atópica es una enfermedad cutánea compleja, inflamatoria y crónica, que ocurre típicamente en individuos con una historia personal o familiar de atopia. Se caracteriza por lesiones de dermatitis, prurito y piel seca (xerosis) que evolucionan con curso crónico y brotes intermitentes que alternan con periodos de remisión. La padecen entre 5 y 15 % de la población general, entre 10 y 20 % de la población pediátrica y entre 1 y 3 % de la población adulta.  Caso clínico: hombre de 19 años, con dermatitis atópica severa (SCORAD de 84.3) e hiper-IgE (34 400 UI/mL). Se prescribió deflazacort y uso de cremas cicatrizantes y emolientes, así como de gel libre de detergente, tratamiento con el cual no evolucionó favorablemente, por lo que se indicó la combinación de deflazacort, metotrexate, tacrolimus y factor de transferencia, con la cual se obtuvieron excelentes resultados.  Conclusión: en la literatura se describen numerosos algoritmos para el tratamiento de la DA, pero la evolución de la enfermedad es la que marca la pauta para el tratamiento que debe seguirse.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Atopic dermatitis (AD) is a chronic inflammatory and complex skin disease, typically occurring in individuals with a personal or family history of atopy. It is characterized by lesions of dermatitis, pruritus and dry skin (xerosis) that evolve with chronic course and intermittent outbreaks alternating with remission phases. AD appears from 5-15 % of the general population, 10-20 % of the pediatric population, and 1-3 % of the adult population.  Case report: A 19-year-old male patient with a severe AD (SCORAD of 84.3), and hyper-IgE (34 400 UI/mL), who was treated with deflazacort, Healing creams and emollients, as well as detergent-free gel. With which did not progress favorably, so a combinated therapy with deflazacort, methotrexate, tacrolimus, and transfer factor was prescribed, obtaining excellent results.  Conclusion: There are many algorithms reported in the literature for the treatment of AD, but the evolution of the disease is the only one that will give us the guidelines for the treatment to be followed.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Dermatitis atópica]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad inflamatoria crónica de la piel]]></kwd>
<kwd lng="es"><![CDATA[inmunoglobulina E]]></kwd>
<kwd lng="en"><![CDATA[Atopic dermatitis]]></kwd>
<kwd lng="en"><![CDATA[Chronic inflammatory skin disease]]></kwd>
<kwd lng="en"><![CDATA[Immunoglobulin E]]></kwd>
</kwd-group>
</article-meta>
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