<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092023000300166</article-id>
<article-id pub-id-type="doi">10.35366/111291</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[VO2máx como marcador pronóstico de mortalidad en pacientes con choque séptico en unidad de terapia intensiva]]></article-title>
<article-title xml:lang="en"><![CDATA[Maximun oxygen uptake as a pronostic marker of mortality in patients with septic shock in intensive care unit]]></article-title>
<article-title xml:lang="pt"><![CDATA[VO2max como marcador prognóstico de mortalidade em pacientes com choque séptico na unidade de terapia intensiva]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quezada Rentería]]></surname>
<given-names><![CDATA[Ricardo Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tapia Perales]]></surname>
<given-names><![CDATA[Juan Gamaliel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez García]]></surname>
<given-names><![CDATA[Víctor Hugo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moran Guel]]></surname>
<given-names><![CDATA[Elida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de Especialidades No. 71  ]]></institution>
<addr-line><![CDATA[Torreón Coahuila]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>37</volume>
<numero>3</numero>
<fpage>166</fpage>
<lpage>177</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092023000300166&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092023000300166&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092023000300166&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[resumen está disponible en el texto completo]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  septic shock is a state of imbalance between oxygen supply and demand in the organism, dysregulation increases progressive cellular damage that ends in multiple organ failure; knowing and using preventive maneuvers allows avoiding further damage. Oxygen transport presents both the oxygen delivery component (DO2) and the rate of oxygen consumption (VO2). Low oxygen availability is called dysoxia, and its clinical expression is the presence of multiorgan dysfunction. It may be due to inadequate oxygen supply or a defect in oxygen utilization in the mitochondria, which is called cytopathic hypoxia. VO2max (maximal oxygen uptake) is the ability to carry and consume oxygen during a stress event and can be a useful tool for early detection of patients with more severe disease.  Objective:  to determine the maximum oxygen consumption (VO2) in patients with septic shock criteria hospitalized in the intensive care unit (ICU) as a predictor of mortality.  Material and methods:  single-center, descriptive prospective cohort analysis study, patients with diagnosis of septic shock were included which were admitted to ICU during December 2021-June 2022, mortality risk variables were studied, reason for ICU discharge, sequential organ failure assessment scale (SOFA), assessment scale for severe and chronic diseases (APACHE), VO2max by Niels Uth formula VO2max = 15 × (maximum heart rate for age/basal heart rate). Sample size was calculated with expected proportion formula with a sample of n = 80. At admission, heart rate was identified to calculate VO2max based on the formula VO2max = 15 × (maximum heart rate for age/basal heart rate), then SOFA and APACHE II mortality scales were calculated, and subsequently follow-up assessment was performed 12 hours after diagnosis of septic shock, calculating VO2max, and outcome was followed up at discharge.  Results:  a complete analysis was performed using the SPSS 22.0.0.0 statistical package. It was divided into two groups for analysis. One group consisted of patients who survived and were discharged due to improvement and the other consisted of patients who died. The analysis of VO2max at 12 hours was divided into two risk groups using 19 mL/kg/min as the cohort point. A significant statistical difference was found with a p of 0.001. Of the patients in the low-risk group, 44 (100% of the patients in this group) were discharged due to improvement, and of the patients in the high-risk group at 12 hours, 2.3% were discharged due to improvement and 42 patients were discharged due to death (97.7% of the patients in the high-risk group). With a 47% risk difference in risk of death by maintaining a VO2max below 19 mL/kg/min at 12 hours and a VO2max above 19 mL/kg/h has a 51% risk difference for patient survival, with a sensitivity of 100% and a specificity of 76% with an RR of 0.74 with a p of 0.001.  Conclusion:  VO2max could be a useful tool to identify patients with adequate resuscitation. This study suggests that an increase in VO2max at 12 hours above 19 mL/kg/min represents adequate resuscitation with a decrease in mortality of the patient with septic shock.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  o choque séptico é um estado de desequilíbrio entre a oferta e a demanda de oxigênio no corpo, a desregulação aumenta o dano celular progressivo que termina na falência de múltiplos órgãos, conhecer e usar manobras preventivas permite evitar danos posteriores. O transporte de oxigênio apresenta tanto o componente de disponibilidade (DO2) quanto a taxa de consumo deste (VO2). A baixa disponibilidade de oxigênio é chamada de disoxia, e sua expressão clínica é a presença de disfunção de múltiplos órgãos. Pode ser devido ao suprimento inadequado de oxigênio ou a um defeito na utilização de oxigênio nas mitocôndrias, o que é chamado de hipóxia citopática. O VO2max é a capacidade de transportar e consumir oxigênio durante um evento de estresse e pode ser uma ferramenta útil para a detecção precoce de pacientes com doenças mais graves.  Objetivo:  determinar o consumo máximo de oxigênio (VO2) em pacientes com critérios de choque séptico hospitalizados na unidade de cuidados intensivos como preditor de mortalidade.  Material e métodos:  estudo de coorte prospectivo unicêntrico e descritivo, foram incluídos pacientes com diagnóstico de choque séptico internados na unidade de terapia intensiva no período de dezembro de 2021 a junho de 2022. Foram estudadas as variáveis &#8203;&#8203;de risco de mortalidade, motivo da alta da UTI, pontuação da escala de falha orgânica secuencial (SOFA), escala de avaliação de doenças graves e crônicas (APACHE), VO2 max pela fórmula de Niels Uth VO2max = 15 × (frequência cardíaca máxima para a idade/frequência cardíaca basal). O tamanho da amostra foi calculado usando a fórmula da proporção esperada com uma amostra de n = 80 no momento da admissão, a frequência cardíaca na admissão foi identificada para calcular o VO2max com base na fórmula do VO2max = 15 × (frequência cardíaca máxima para idade/frequência cardíaca inicial), posteriormente foram calculadas as escalas de mortalidade SOFA e APACHE II e a avaliação de acompanhamento foi realizada 12 horas após o diagnóstico de choque séptico, calculando o VO2 max e monitorando seu resultado na alta.  Resultados:  realizou-se uma análise completa usando o pacote estatístico SPSS 22.0.0. Foi dividido em 2 grupos para análise. Um grupo formado pelos pacientes que sobreviveram e receberam alta por melhora e o outro pelos pacientes que faleceram. Na análise do VO2max em 12 horas, dividiu-se em dois grupos de risco utilizando como ponto de coorte 19 mL/kg/min, encontrou-se uma diferença estatisticamente significativa com p de 0.001 dos pacientes que estão dentro do grupo de baixo risco grupo tiveram alta 44 pacientes por melhora equivalente a 100% dos pacientes deste grupo e dos pacientes que estavam no grupo de alto risco em 12 horas, obteve-se 1 alta por melhora equivalente a 2.3% e 42 pacientes tiveram alta por óbito equivalente a 97.7/% dos pacientes do grupo de alto risco. Com uma diferença de risco de 47% no risco de morte ao manter um VO2max abaixo de 19 mL/kg/min em 12 horas e um VO2max acima de 19 mL/kg/h, há uma diferença de risco de 51% para a sobrevida dos pacientes, com uma sensibilidade de 100% e uma especificidade de 76% com um RR de 0.74 com um p de 0.001.  Conclusão:  o VO2max pode ser uma ferramenta útil para identificar pacientes com ressuscitação adequada, este estudo sugere que o aumento do VO2max em 12 horas acima de 19 mL/kg/min representa uma ressuscitação adequada com diminuição da mortalidade do paciente com choque séptico.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[choque séptico]]></kwd>
<kwd lng="es"><![CDATA[VO2máx]]></kwd>
<kwd lng="es"><![CDATA[disponibilidad de oxígeno]]></kwd>
<kwd lng="en"><![CDATA[septic shock]]></kwd>
<kwd lng="en"><![CDATA[VO2max]]></kwd>
<kwd lng="en"><![CDATA[oxygen availability]]></kwd>
<kwd lng="pt"><![CDATA[choque séptico]]></kwd>
<kwd lng="pt"><![CDATA[VO2max]]></kwd>
<kwd lng="pt"><![CDATA[disponibilidade de oxigênio]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rhodes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Evans]]></surname>
<given-names><![CDATA[LE]]></given-names>
</name>
<name>
<surname><![CDATA[Alhazzani]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016]]></article-title>
<source><![CDATA[Crit Care Med]]></source>
<year>2017</year>
<volume>45</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>486-552</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Pasquale]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Moss]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
<name>
<surname><![CDATA[Cerutti]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hemorrhage prediction models in surgical intensive care: bedside monitoring data adds information to lab values]]></article-title>
<source><![CDATA[IEEE J Biomed Health Inform]]></source>
<year>2017</year>
<volume>21</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1703-10</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hall]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
</person-group>
<source><![CDATA[Guyton and hall textbook of medical physiology]]></source>
<year>2011</year>
<edition>3th</edition>
<publisher-name><![CDATA[Elsevier: Saunders]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Belletti]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Landoni]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Lomivorotov]]></surname>
<given-names><![CDATA[VV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Adrenergic downregulation in critical care: molecular mechanisms and therapeutic evidence]]></article-title>
<source><![CDATA[J Cardiothorac Vasc Anesth]]></source>
<year>2020</year>
<volume>34</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1023-41</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vasudevan]]></surname>
<given-names><![CDATA[NT]]></given-names>
</name>
<name>
<surname><![CDATA[Mohan]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Goswami]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
<name>
<surname><![CDATA[Naga Prasad]]></surname>
<given-names><![CDATA[SV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Regulation of &#946;-adrenergic receptor function: an emphasis on receptor resensitization]]></article-title>
<source><![CDATA[Cell Cycle]]></source>
<year>2011</year>
<volume>10</volume>
<numero>21</numero>
<issue>21</issue>
<page-range>3684-91</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rockman]]></surname>
<given-names><![CDATA[HA]]></given-names>
</name>
<name>
<surname><![CDATA[Koch]]></surname>
<given-names><![CDATA[WJ]]></given-names>
</name>
<name>
<surname><![CDATA[Lefkowitz]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Seven-transmembrane-spanning receptors and heart function]]></article-title>
<source><![CDATA[Nature]]></source>
<year>2002</year>
<volume>415</volume>
<numero>6868</numero>
<issue>6868</issue>
<page-range>206-12</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferguson]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling]]></article-title>
<source><![CDATA[Pharmacol Rev]]></source>
<year>2001</year>
<volume>53</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-24</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chapleau]]></surname>
<given-names><![CDATA[MW]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Meyrelles]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Ma]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Abboud]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanisms determining sensitivity of baroreceptor afferents in health and disease]]></article-title>
<source><![CDATA[Ann N Y Acad Sci]]></source>
<year>2001</year>
<volume>940</volume>
<page-range>1-19</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rubulotta]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
<name>
<surname><![CDATA[Ramsay]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Parker]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An international survey: public awareness and perception of sepsis]]></article-title>
<source><![CDATA[Crit Care Med]]></source>
<year>2009</year>
<volume>37</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>167-70</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Singer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Deutschman]]></surname>
<given-names><![CDATA[CS]]></given-names>
</name>
<name>
<surname><![CDATA[Seymour]]></surname>
<given-names><![CDATA[CW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The third international consensus definitions for sepsis and septic shock (sepsis-3)]]></article-title>
<source><![CDATA[JAMA]]></source>
<year>2016</year>
<volume>315</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>801-10</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kalantari]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mallemat]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Weingart]]></surname>
<given-names><![CDATA[SD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis definitions: the search for gold and what CMS got wrong]]></article-title>
<source><![CDATA[West J Emerg Med]]></source>
<year>2017</year>
<volume>18</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>951-6</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lv]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pathophysiology of sepsis-induced myocardial dysfunction]]></article-title>
<source><![CDATA[Mil Med Res]]></source>
<year>2016</year>
<volume>3</volume>
<page-range>30</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sevilla]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[O&#8217;Horo]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Velagapudi]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Pulido]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Correlation of left ventricular systolic dysfunction determined by low ejection fraction and 30-day mortality in patients with severe sepsis and septic shock: a systematic review and meta-analysis]]></article-title>
<source><![CDATA[J Crit Care]]></source>
<year>2014</year>
<volume>29</volume>
<page-range>495-9</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Romero M Del]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Cabrera]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Villagómez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Méndez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Guzmán]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Solache]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Disfunción ventricular asociada a sepsis]]></article-title>
<source><![CDATA[Rev Asoc Mex Med Crit y Ter Int]]></source>
<year>2009</year>
<volume>23</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>10-5</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rhodes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Evans Le, Alhazzani]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016]]></article-title>
<source><![CDATA[Intensive Care Med]]></source>
<year>2017</year>
<volume>43</volume>
<page-range>304-77</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vincent]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<source><![CDATA[The cardiovascular management of sepsis. year book of intensive care and emergency medicine]]></source>
<year>2008</year>
<publisher-loc><![CDATA[Germany ]]></publisher-loc>
<publisher-name><![CDATA[Spinger]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Walley]]></surname>
<given-names><![CDATA[KR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis-induced myocardial dysfunction]]></article-title>
<source><![CDATA[Curr Opin Crit Care]]></source>
<year>2018</year>
<volume>24</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>292-9</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Andresen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Regueira]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Disfunción miocárdica en la sepsis]]></article-title>
<source><![CDATA[Rev Med Chile]]></source>
<year>2010</year>
<volume>138</volume>
<page-range>888-96</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nagueh]]></surname>
<given-names><![CDATA[SF]]></given-names>
</name>
<name>
<surname><![CDATA[Smiseth]]></surname>
<given-names><![CDATA[OA]]></given-names>
</name>
<name>
<surname><![CDATA[Appleton]]></surname>
<given-names><![CDATA[CP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging]]></article-title>
<source><![CDATA[J Am Soc Echocardiogr]]></source>
<year>2016</year>
<volume>29</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>277-314</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Suarez]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Lopez]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Mancebo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Zapata]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[diastolic dysfunction in the critically ill patient]]></article-title>
<source><![CDATA[Med Intensiva]]></source>
<year>2016</year>
<volume>40</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>499-510</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Peña-Juarez]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Garrido-García]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[Zapata-Martínez]]></surname>
<given-names><![CDATA[SG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[miocardiopatía séptica en pacientes pediátricos: fisiopatología y presentación clínica]]></article-title>
<source><![CDATA[Acta Colomb Cuid Intensivo]]></source>
<year>2018</year>
<volume>18</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>179-89</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fenton]]></surname>
<given-names><![CDATA[KE]]></given-names>
</name>
<name>
<surname><![CDATA[Parker]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[cardiac function and dysfunction in sepsis]]></article-title>
<source><![CDATA[Clin Chest Med]]></source>
<year>2016</year>
<volume>37</volume>
<page-range>289-98</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kakihana]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Ito]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Nakahara]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Yamaguchi]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Yasuda]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis-induced myocardial dysfunction: pathophysiology and management]]></article-title>
<source><![CDATA[J Intensive Care]]></source>
<year>2016</year>
<volume>4</volume>
<page-range>22</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hochstadt]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Meroz]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Landesberg]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Myocardial dysfunction in severe sepsis and septic shock: ¿more question tan answers?]]></article-title>
<source><![CDATA[J Cardiothorac Vasc Anesth]]></source>
<year>2011</year>
<volume>25</volume>
<page-range>526-35</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parrillo]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Burch]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Shelhamer Jh, Parker]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Netanson]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Schuette]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A circulating myocardial depressant substance in humans with septic shock]]></article-title>
<source><![CDATA[J Clin Invest]]></source>
<year>1985</year>
<volume>76</volume>
<page-range>1539-53</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Balija]]></surname>
<given-names><![CDATA[TM]]></given-names>
</name>
<name>
<surname><![CDATA[Lowry]]></surname>
<given-names><![CDATA[SF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipopolysaccharide and sepsis-associated myocardial dysfunction]]></article-title>
<source><![CDATA[Curr Opin Infect Dis]]></source>
<year>2011</year>
<volume>24</volume>
<page-range>248-53</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Carr]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Goyal]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gaieski]]></surname>
<given-names><![CDATA[DF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis: the inflammatory foundation of pathophysiology and therapy]]></article-title>
<source><![CDATA[Hosp Pract (1995)]]></source>
<year>2011</year>
<volume>39</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>99-112</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Bd]]></surname>
<given-names><![CDATA[Bissell]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Misdirected sympathy: the role of sympatholysis in sepsis and septic shock]]></article-title>
<source><![CDATA[J Intensive Care Med]]></source>
<year>2018</year>
<volume>33</volume>
<page-range>74-86</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ostrowski]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
<name>
<surname><![CDATA[Gaini]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Pedersen]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Johansson]]></surname>
<given-names><![CDATA[PI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sympathoadrenal activation and endothelial damage in patients with varying degrees of acute infectious disease: an observational study]]></article-title>
<source><![CDATA[J Crit Care]]></source>
<year>2015</year>
<volume>30</volume>
<page-range>90-6</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cariou]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Pinsky]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
<name>
<surname><![CDATA[Monchi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Is myocardial adrenergic responsiveness depressed in human septic shock?]]></article-title>
<source><![CDATA[Intensive Care Med]]></source>
<year>2008</year>
<volume>34</volume>
<page-range>917-22</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rudiger]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Beta-block the septic heart]]></article-title>
<source><![CDATA[Crit Care Med]]></source>
<year>2010</year>
<volume>38</volume>
<page-range>s608-12</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schmidt]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Kurt]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Holcherl]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Bucher]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of NF-kappaB activity prevents downregulation of alpha1-adrenergic receptors and circulatory failure during CLP-induced sepsis]]></article-title>
<source><![CDATA[Shock]]></source>
<year>2009</year>
<volume>32</volume>
<page-range>239-46</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ackland]]></surname>
<given-names><![CDATA[GL]]></given-names>
</name>
<name>
<surname><![CDATA[Kazymov]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Marina]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Singer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gourine]]></surname>
<given-names><![CDATA[AV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Peripheral neural detection of danger-associated and pathogen-associated molecular patterns]]></article-title>
<source><![CDATA[Crit Care Med]]></source>
<year>2013</year>
<volume>41</volume>
<page-range>e85-92</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Godin]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Tg]]></surname>
<given-names><![CDATA[Buchman]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Uncoupling of biological oscillators]]></article-title>
<source><![CDATA[Crit Care Med]]></source>
<year>1996</year>
<volume>24</volume>
<page-range>1107-16</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sharshar]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Gray]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[De La Grandmaison]]></surname>
<given-names><![CDATA[Gl]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2003</year>
<volume>362</volume>
<page-range>1799-805</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nardocci]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Abarzúa]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide]]></article-title>
<source><![CDATA[J Neuroimmunol]]></source>
<year>2015</year>
<volume>278</volume>
<page-range>44-52</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ramchandra]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Wan]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Sg]]></surname>
<given-names><![CDATA[Hood]]></given-names>
</name>
<name>
<surname><![CDATA[Frithiof]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Bellomo]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[May]]></surname>
<given-names><![CDATA[CN]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Septic shock induces distinct changes in sympathetic nerve activity to the heart and kidney in conscious sheep]]></article-title>
<source><![CDATA[Am J Physiol Integr Comp Physiol]]></source>
<year>2009</year>
<volume>297</volume>
<page-range>r1247-53</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vayssettes-Courchay]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Bouysset]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Tj]]></surname>
<given-names><![CDATA[Verbeuren]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sympathetic activation and tachycardia in lipopolysaccharide treated rats are temporally correlated and unrelated to the baroreflex]]></article-title>
<source><![CDATA[Auton Neurosci]]></source>
<year>2005</year>
<volume>120</volume>
<page-range>35-45</page-range></nlm-citation>
</ref>
<ref id="B39">
<label>39</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pavlov]]></surname>
<given-names><![CDATA[VA]]></given-names>
</name>
<name>
<surname><![CDATA[Tracey]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The cholinergic anti-infammatory pathway]]></article-title>
<source><![CDATA[Brain Behav Immun]]></source>
<year>2005</year>
<volume>19</volume>
<page-range>493-9</page-range></nlm-citation>
</ref>
<ref id="B40">
<label>40</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tracey]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The inflammatory reflex]]></article-title>
<source><![CDATA[Nature]]></source>
<year>2002</year>
<volume>420</volume>
<page-range>853-9</page-range></nlm-citation>
</ref>
<ref id="B41">
<label>41</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bravi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Longtin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Seely]]></surname>
<given-names><![CDATA[AJE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Review and classification of variability analysis techniques with clinical applications]]></article-title>
<source><![CDATA[Biomed Eng Online]]></source>
<year>2011</year>
<volume>10</volume>
<page-range>90</page-range></nlm-citation>
</ref>
<ref id="B42">
<label>42</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jarkovska]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Valesova]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Chvojka]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heart rate variability in porcine progressive peritonitis-induced sepsis]]></article-title>
<source><![CDATA[Front Physiol]]></source>
<year>2016</year>
<volume>6</volume>
<page-range>412</page-range></nlm-citation>
</ref>
<ref id="B43">
<label>43</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fairchild]]></surname>
<given-names><![CDATA[KD]]></given-names>
</name>
<name>
<surname><![CDATA[Saucerman]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Raynor]]></surname>
<given-names><![CDATA[LL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Endotoxin depresses heart rate variability in mice: cytokine and steroid effects]]></article-title>
<source><![CDATA[Am J Physiol Integr Comp Physiol]]></source>
<year>2009</year>
<volume>297</volume>
<page-range>r1019-27</page-range></nlm-citation>
</ref>
<ref id="B44">
<label>44</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Venditti]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Di Stefano]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Di Meo]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mitochondrial metabolism of reactive oxygen species]]></article-title>
<source><![CDATA[Mitochondrion]]></source>
<year>2013</year>
<volume>13</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>71-82</page-range></nlm-citation>
</ref>
<ref id="B45">
<label>45</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gifford]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Garten]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[Nelson]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Symmorphosis and skeletal muscle VO2 max: in vivo and in vitro measures reveal differing constraints in the exercise? trained and untrained human]]></article-title>
<source><![CDATA[J Physiol]]></source>
<year>2016</year>
<volume>594</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1741-51</page-range></nlm-citation>
</ref>
<ref id="B46">
<label>46</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lundby]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Montero]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Crosstalk opposing view: diffusion limitation of O2 from microvessels into muscle does not contribute to the limitation of VO2max]]></article-title>
<source><![CDATA[J Physiol]]></source>
<year>2015</year>
<volume>593</volume>
<numero>17</numero>
<issue>17</issue>
<page-range>3759-61</page-range></nlm-citation>
</ref>
<ref id="B47">
<label>47</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fink]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cytopathic hypoxia. mitochondrial dysfunction as a mechanism contributing to organ dysfunction in sepsis]]></article-title>
<source><![CDATA[Crit Care Clin]]></source>
<year>2001</year>
<volume>17</volume>
<page-range>219-37</page-range></nlm-citation>
</ref>
<ref id="B48">
<label>48</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koutlianos]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Dimitros]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Metaxas]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Cansiz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Deligiannis]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kouidi]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Indirect estimation of VO2max in athletes by ACSM&#8217;s equation: valid or not?]]></article-title>
<source><![CDATA[Hippokratia]]></source>
<year>2013</year>
<volume>17</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>136-40</page-range></nlm-citation>
</ref>
<ref id="B49">
<label>49</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Elliott]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
<name>
<surname><![CDATA[Skowno]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Prabhu]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Noakes]]></surname>
<given-names><![CDATA[TD]]></given-names>
</name>
<name>
<surname><![CDATA[Ansley]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evidence of cardiac functional reserve upon exhaustion during incremental exercise to determine VO2max]]></article-title>
<source><![CDATA[Br J Sports Med]]></source>
<year>2015</year>
<volume>49</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>128-32</page-range></nlm-citation>
</ref>
<ref id="B50">
<label>50</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bazerbashi]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Merriman]]></surname>
<given-names><![CDATA[KW]]></given-names>
</name>
<name>
<surname><![CDATA[Toale]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Low tissue oxygen saturation at emergency center triage is predictive of intensive care unit admission]]></article-title>
<source><![CDATA[J Crit Care]]></source>
<year>2014</year>
<volume>29</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>775-9</page-range></nlm-citation>
</ref>
<ref id="B51">
<label>51</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Malekmohammad]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ahmadi-Nejad]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Adimi]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Jamaati]]></surname>
<given-names><![CDATA[HR]]></given-names>
</name>
<name>
<surname><![CDATA[Marashian]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of maximum O2 consumption: using ergo-spirometry in severe heart failure]]></article-title>
<source><![CDATA[Acta Med Iran]]></source>
<year>2012</year>
<volume>50</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>619-23</page-range></nlm-citation>
</ref>
<ref id="B52">
<label>52</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Annane]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Bellissant]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Cavaillon]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Septic shock]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2005</year>
<volume>365</volume>
<numero>9453</numero>
<issue>9453</issue>
<page-range>63-78</page-range></nlm-citation>
</ref>
<ref id="B53">
<label>53</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Makey]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Berger]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
<name>
<surname><![CDATA[Cabral]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[Celli]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Folch]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Whyte]]></surname>
<given-names><![CDATA[RI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Maximal oxygen uptake--risk predictor of NSCLC resection in patients with comorbid emphysema: lessons from NETT]]></article-title>
<source><![CDATA[Semin Thorac Cardiovasc Surg]]></source>
<year>2015</year>
<volume>27</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>225-31</page-range></nlm-citation>
</ref>
<ref id="B54">
<label>54</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bolliger]]></surname>
<given-names><![CDATA[CT]]></given-names>
</name>
<name>
<surname><![CDATA[Jordan]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Soler]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Exercise capacity as a predictor of postoperative complications in lung resection candidates]]></article-title>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>1995</year>
<volume>151</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1472-80</page-range></nlm-citation>
</ref>
<ref id="B55">
<label>55</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Licker]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Schnyder]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Frey]]></surname>
<given-names><![CDATA[JG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Impact of aerobic exercise capacity and procedure-related factors in lung cancer surgery]]></article-title>
<source><![CDATA[Eur Respir J]]></source>
<year>2011</year>
<volume>37</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1189-98</page-range></nlm-citation>
</ref>
<ref id="B56">
<label>56</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cabezas]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
<name>
<surname><![CDATA[Meleán]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[Torrealba]]></surname>
<given-names><![CDATA[HE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Consumo máximo de oxígeno (vo2max) para predecir riesgos postoperatorios en cirugía abdominal electiva]]></article-title>
<source><![CDATA[Revista de la Facultad de Medicina]]></source>
<year>2001</year>
<volume>24</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>163-71</page-range></nlm-citation>
</ref>
<ref id="B57">
<label>57</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Astorino]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[DeRevere]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Anderson]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Blood lactate concentration is not related to the increase in cardiorespiratory fitness induced by high intensity interval training]]></article-title>
<source><![CDATA[Int J Environ Res Public Health]]></source>
<year>2019</year>
<volume>16</volume>
<numero>16</numero>
<issue>16</issue>
<page-range>2845</page-range></nlm-citation>
</ref>
<ref id="B58">
<label>58</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vincent]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[de Mendonça]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cantraine]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Moreno]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Takala]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Suter]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on &#8220;sepsis-related problems&#8221; of the European Society of Intensive Care Medicine]]></article-title>
<source><![CDATA[Crit Care Med]]></source>
<year>1998</year>
<volume>26</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1793-800</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
