<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092016000200130</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Glicocálix. Una estructura a considerar en el enfermo grave]]></article-title>
<article-title xml:lang="en"><![CDATA[Glycocalyx. A structure to consider in the critically ill patient]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carrillo Esper]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zepeda Mendoza]]></surname>
<given-names><![CDATA[Adriana Denise]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores Rivera]]></surname>
<given-names><![CDATA[Oscar Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz Girón Gidi]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Martínez]]></surname>
<given-names><![CDATA[Itzel Monserrat]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Araiza Garaygordobil]]></surname>
<given-names><![CDATA[Diego]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Academia Nacional de Medicina Academia Mexicana de Cirugía ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Fundación Clínica Médica Sur  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2016</year>
</pub-date>
<volume>30</volume>
<numero>2</numero>
<fpage>130</fpage>
<lpage>136</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092016000200130&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092016000200130&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092016000200130&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Las células endoteliales conforman el recubrimiento interno del corazón, vasos sanguíneos y linfáticos. La porción apical de las células endoteliales contiene glicocálix, una red compleja de macromoléculas, incluyendo proteínas de unión, proteoglicanos y glicoproteínas. Esta compleja red recubre las células endoteliales y sus hendiduras en su segmento luminal. El glicocálix tiene un papel fundamental en la fisiología microvascular y endotelial, en particular, en la regulación del tono microvascular y la permeabilidad endotelial, el mantenimiento de la presión oncótica a través de la barrera endotelial, la regulación de la adhesión y migración de leucocitos e inhibición de trombosis intravascular. Mediante estos mecanismos, el glicocálix contribuye a la regulación del flujo sanguíneo y asegura las funciones metabólicas y hemodinámicas locales de los órganos. El objetivo de este trabajo es revisar los conceptos actuales relacionados con la función y disfunción del glicocálix y su impacto en el enfermo grave.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Endothelial cells line the inner portion of the heart, blood vessels, and lymphatic vessels. The apical side of the endothelial cells is the site for glycocalyx, which is a complex network of macromolecules, including cell-bound proteoglycans and sialoproteins. This complex network envelops endothelial cells on their luminal side and inside clefts. The glycocalyx plays a key role in microvascular and endothelial physiology, in particular in regulating microvascular tone and endothelial permeability, maintaining an oncotic gradient across the endothelial barrier, regulating adhesion/migration of leukocytes, and inhibiting intravascular thrombosis. Acting through this mechanism, the glycocalyx contributes to the regulation of the local blood flow of organs and acts as an effector of metabolic coupling between organ function and local hemodynamics. The aim of this paper is to review current concepts related to function and dysfunction of glycocalyx and its impact in the critically ill.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Glicocálix]]></kwd>
<kwd lng="es"><![CDATA[endotelio]]></kwd>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[Glycocalyx]]></kwd>
<kwd lng="en"><![CDATA[endothelium]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
</kwd-group>
</article-meta>
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