<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2444-6483</journal-id>
<journal-title><![CDATA[Endoscopia]]></journal-title>
<abbrev-journal-title><![CDATA[Endoscopia]]></abbrev-journal-title>
<issn>2444-6483</issn>
<publisher>
<publisher-name><![CDATA[Asociación Mexicana de Endoscopia Gastrointestinal A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2444-64832025000200048</article-id>
<article-id pub-id-type="doi">10.24875/end.24000015</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Carcinoma neuroendocrino de células grandes en el estómago. Reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Large cell neuroendocrine carcinoma of the stomach. Case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cortés-Juárez]]></surname>
<given-names><![CDATA[Katya]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz-Ballesteros]]></surname>
<given-names><![CDATA[Eduardo J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castro-Sánchez]]></surname>
<given-names><![CDATA[Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Sosa]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valdez-Ocrospoma]]></surname>
<given-names><![CDATA[Danery]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cortés-Paz]]></surname>
<given-names><![CDATA[Denice]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Servicio de Gastroenterología Servicio de Gastroenterología ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Servicio de Oncología Servicio de Oncología ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Servicio de Patología Servicio de Patología ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Ángeles Puebla Servicio de Radiología ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>37</volume>
<numero>2</numero>
<fpage>48</fpage>
<lpage>50</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2444-64832025000200048&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2444-64832025000200048&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2444-64832025000200048&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El carcinoma neuroendocrino de células grandes es una neoplasia maligna con baja incidencia. En este reporte presentamos el caso de un carcinoma neuroendocrino de células grandes en el estómago y una breve descripción del abordaje multidisciplinario. Presentamos el caso de un paciente con dolor epigástrico, saciedad precoz y pérdida de peso de un mes de evolución, con reporte tomográfico contrastado de una tumoración de aspecto polipoide en estómago de 13.6 × 8.8 cm, a quien se le realizó una endoscopia superior, en la cual se halló una tumoración que se extendía y deformaba la mitad del cuerpo gástrico hasta la curvatura menor, con crecimiento tumoral intrínseco y extrínseco, de aspecto cerebroide con bordes mal definidos y zonas de ulceración. Por medio de histopatología se diagnosticó carcinoma neuroendocrino de células grandes, invasor, ulcerado, grado 3 (OMS). Se iniciaron ciclos de quimioterapia a base de etopósido y carboplatino. De acuerdo con la literatura, el carcinoma neuroendocrino es un tumor raro y agresivo que generalmente se diagnostica de forma incidental en estadios avanzados. Su pronóstico es malo, con una sobrevida de 11 a 12 meses en estadios avanzados, con cirugía la sobrevida a 5 años alcanza hasta el 25.6%.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Large cell neuroendocrine carcinoma is a malignant neoplasm with a low incidence. In this report we present a case of a large cell neuroendocrine carcinoma in the stomach and a brief description of the multidisciplinary approach. We present a patient with epigastric pain, early satiety and weight loss with one month of evolution, contrasted CT scan report with a polypoid tumor lesion in the stomach measuring 13.6 × 8.8 cm, who underwent an upper endoscopy, finding a tumor that extended and deformed the middle of the gastric body to the lesser curvature, with intrinsic and extrinsic tumor growth, a cerebroid appearance and poorly defined borders, with areas of ulceration. Histopathology reported invasive, ulcerated, large cell neuroendocrine carcinoma, grade 3 (WHO). Cycles of chemotherapy based on etoposide and carboplatin were started. According to literature, neuroendocrine carcinoma is a rare and aggressive tumor that is generally diagnosed incidentally in advanced stages. The prognosis is poor, with a survival of 11 to 12 months in advanced stages, with surgery reaching a 5-year survival of up to 25.6%.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Carcinoma neuroendocrino]]></kwd>
<kwd lng="es"><![CDATA[Endoscopia]]></kwd>
<kwd lng="es"><![CDATA[Tumor gástrico]]></kwd>
<kwd lng="es"><![CDATA[Ki-67]]></kwd>
<kwd lng="es"><![CDATA[Gastrectomía]]></kwd>
<kwd lng="en"><![CDATA[Neuroendocrine carcinoma]]></kwd>
<kwd lng="en"><![CDATA[Endoscopy]]></kwd>
<kwd lng="en"><![CDATA[Gastric tumor]]></kwd>
<kwd lng="en"><![CDATA[Ki-67. Gastrectomy]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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