<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-7203</journal-id>
<journal-title><![CDATA[Acta médica Grupo Ángeles]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. Grupo Ángeles]]></abbrev-journal-title>
<issn>1870-7203</issn>
<publisher>
<publisher-name><![CDATA[Grupo Ángeles, Servicios de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-72032022000100050</article-id>
<article-id pub-id-type="doi">10.35366/103556</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Estetrol: ¿un nuevo paradigma en terapia ginecológica?]]></article-title>
<article-title xml:lang="en"><![CDATA[Estetrol: a new paradigm in gynecological therapy?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Navarrete Horta]]></surname>
<given-names><![CDATA[Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guerrero Carreño]]></surname>
<given-names><![CDATA[Francisco Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valdés Aguerrebere]]></surname>
<given-names><![CDATA[Paulina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vázquez Estrada]]></surname>
<given-names><![CDATA[Leopoldo Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Angeles Lindavista  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Angeles Lindavista  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Médica Sur  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>20</volume>
<numero>1</numero>
<fpage>50</fpage>
<lpage>57</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-72032022000100050&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-72032022000100050&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-72032022000100050&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El estetrol (E4) es un estrógeno natural producido por el feto humano y que pasa a la sangre materna en niveles relativamente altos durante el embarazo. A lo largo de las últimas dos décadas, se ha demostrado que sus perfiles farmacodinámico y farmacocinético, su tolerabilidad y su margen de seguridad son muy favorables. En este sentido, E4 potencialmente representa un gran avance en la terapia ginecológica para la anticoncepción y el manejo de la menopausia; también muestra aplicabilidad en otros campos terapéuticos como: cánceres hormono-dependientes (mama y próstata), osteoporosis, neuroprotección, dolor muscular y cicatrización de heridas. Presentamos una revisión de la evidencia actual de esta &#8220;nueva&#8221; opción terapéutica hormonal cuya inclusión a la práctica clínica ginecológica parece inminente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Estetrol (E4) is a natural estrogen produced by the human fetus and passes into the maternal blood at relatively high levels during pregnancy. Over the past two decades, its pharmacodynamic and pharmacokinetic profiles, tolerability, and safety margin have been shown to be highly favorable. In this sense, E4 potentially represents a great advance in gynecological therapy such as contraception and the management of menopause. E4 also shows applicability in other therapeutic fields such as hormone-dependent cancers (breast and prostate), osteoporosis, neuroprotection, muscle pain, and wound healing. We present hereinafter the current evidence on this &#8220;new&#8221; hormonal therapy option whose inclusion in gynecological clinical practice seems imminent.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Estetrol]]></kwd>
<kwd lng="es"><![CDATA[E4]]></kwd>
<kwd lng="es"><![CDATA[anticoncepción]]></kwd>
<kwd lng="es"><![CDATA[menopausia]]></kwd>
<kwd lng="es"><![CDATA[terapia hormonal]]></kwd>
<kwd lng="en"><![CDATA[Estetrol]]></kwd>
<kwd lng="en"><![CDATA[E4]]></kwd>
<kwd lng="en"><![CDATA[contraception]]></kwd>
<kwd lng="en"><![CDATA[menopause]]></kwd>
<kwd lng="en"><![CDATA[hormonal therapy]]></kwd>
</kwd-group>
</article-meta>
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