<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-1146</journal-id>
<journal-title><![CDATA[Boletín médico del Hospital Infantil de México]]></journal-title>
<abbrev-journal-title><![CDATA[Bol. Med. Hosp. Infant. Mex.]]></abbrev-journal-title>
<issn>1665-1146</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-11462017000200122</article-id>
<article-id pub-id-type="doi">10.1016/j.bmhimx.2016.12.002</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Características citopatológicas de la leucemia aguda en el Hospital de Especialidades Pediátricas de Chiapas, México]]></article-title>
<article-title xml:lang="en"><![CDATA[Cytopathologic features of childhood acute leukemia at the Hospital de Especialidades Pediátricas, Chiapas, Mexico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lepe-Zúñiga]]></surname>
<given-names><![CDATA[José Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jerónimo-López]]></surname>
<given-names><![CDATA[Francisco Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Orantes]]></surname>
<given-names><![CDATA[Jorge Gregorio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de Especialidades Pediátricas Departamento de Investigación ]]></institution>
<addr-line><![CDATA[Tuxtla Gutiérrez Chiapas]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Especialidades Pediátricas Laboratorio de Patología Clínica ]]></institution>
<addr-line><![CDATA[Tuxtla Gutiérrez Chiapas]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<volume>74</volume>
<numero>2</numero>
<fpage>122</fpage>
<lpage>133</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-11462017000200122&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-11462017000200122&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-11462017000200122&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  Se desconocen las características citopatológicas de las leucemias agudas en pacientes de Chiapas, México, ya que es una población relativamente aislada con alto índice de consanguinidad, lo cual podría afectar la evolución y la respuesta terapéutica.  Métodos:  Se clasificaron morfológica, inmunofenotípica y genotípicamente 81 casos de leucemia aguda en pacientes atendidos en el Hospital de Especialidades Pediátricas de Chiapas, indicando riesgo al ingreso y situación al momento del estudio. Los resultados se comparan con información nacional e internacional pertinente.  Resultados:  Se encontró la siguiente proporción de tipos de leucemia aguda: leucemias B, 75.3%; mieloides, 16%; de células T, 3.7%; B-M, 3.7% y de células NK, 1.2%. Las alteraciones genéticas estuvieron presentes en 40.6% de las B y en 69% de las mieloides. La alteración genética se relacionó con la evolución del paciente a corto plazo en las leucemias tipo B; no así en las mieloides. En las B, los casos con el gen MLL alterado fallecieron en menos de un mes, los casos con la translocación t(1;19)(q23;p13) han tenido buena evolución, y aquellos con la t(12;21)(p13;q22) han tenido mala evolución a medio plazo. La hiperdiploidía se presentó en el 20% de los casos B; el 83% de ellos permanecen en remisión de 1 a 12 meses desde el diagnóstico. El 69% de los casos con leucemias mieloides falleció o abandonó el tratamiento en recaída de 15 días a 37 meses del diagnóstico.  Conclusiones:  La proporción de los diferentes tipos de leucemia aguda atendidas en el HEP es similar a la encontrada en otras partes del país. Su comportamiento y desenlace está relacionado con la presencia o ausencia de alteraciones genéticas específicas y no específicas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Background:  Childhood acute leukemia cytological features are unknown in Chiapas, Mexico. Defining these features is important because this is a relatively isolated population with high consanguinity index, and these aspects could determine differences in responses to treatment and outcome.  Methods:  Eighty-one childhood acute leukemia cases treated at the Hospital de Especialidades Pediátricas in Chiapas were characterized by morphology, immunophenotype, genotype, initial risk assignment and status at the time of the study.  Results:  The proportion of leukemic cell types found in this study was B cell, 75.3%; myeloid, 16%; T cell, 3.7% and NK 1.2%. In B cell leukemia, genetic alterations were present in 40.6% of cases and had a specific outcome regardless of initial risk assessment. Cases with MLL gene alteration died within a month from diagnosis. Translocations were present in 17.5% B cases; t(1;19) was present in those with a favorable outcome. The t(12;21) translocation was related to initial remission and midterm relapse and dead. Hyperdiploidy was present in 20% of B cell cases with good outcome. In 38.5%of myeloid cases were translocations and karyotypic abnormalities. Short-term outcome in this group has been poor; 69% have died or abandoned treatment in relapse from 15 days to 37 months after diagnosis.  Conclusions:  Relative frequency of different types of acute leukemia in patients treated at a tertiary level pediatric hospital in Chiapas, Mexico, was similar to the one found in other parts of the country. Patients&#8217; outcome, under a standardized treatment, differs according to the group, the subgroup and the presence and type of genetic alterations.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Leucemia aguda en la infancia]]></kwd>
<kwd lng="es"><![CDATA[Inmunofenotipo]]></kwd>
<kwd lng="es"><![CDATA[Genotipo]]></kwd>
<kwd lng="es"><![CDATA[Chiapas]]></kwd>
<kwd lng="es"><![CDATA[Minorías]]></kwd>
<kwd lng="en"><![CDATA[Childhood acute leukemia]]></kwd>
<kwd lng="en"><![CDATA[Immunophenotype]]></kwd>
<kwd lng="en"><![CDATA[Genotype]]></kwd>
<kwd lng="en"><![CDATA[Chiapas]]></kwd>
<kwd lng="en"><![CDATA[Minorities]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Decreto por el que se reforma y adiciona la Ley General de Salud]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fox-Quesada]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[Diario Oficial de la Federación]]></source>
<year>2003</year>
<volume>15</volume>
<page-range>46-58</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Decreto por el que se crea el Centro Regional de Alta Especialidad de Chiapas, como Organismo Descentralizado de la Administración Pública Federal]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fox-Quesada]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[Diario Oficial de la Federación]]></source>
<year>2006</year>
<volume>29</volume>
<page-range>76-8</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="">
<collab>Secretaría de Salud</collab>
<source><![CDATA[Protocolo de la atención para leucemia linfoblástica. Guía clínica y esquema de tratamiento]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="">
<collab>Secretaría de Salud</collab>
<source><![CDATA[Protocolos técnicos del FPGC. Seguro Popular. Enfermedades de Alto Costo]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[EuroFlow antibody panels for standardized n-dimensional flowcytometric immunophenotyping of normal, reactive and malignant leukocytes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[van Dongen]]></surname>
<given-names><![CDATA[JJM]]></given-names>
</name>
<name>
<surname><![CDATA[Lhermitte]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Böttcher]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Almeida]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[van der Velden]]></surname>
<given-names><![CDATA[VHJ]]></given-names>
</name>
<name>
<surname><![CDATA[Flores-Montero]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Leukemia]]></source>
<year>2012</year>
<volume>26</volume>
<page-range>1908-75</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL)]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Béné]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Castoldi]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Knapp]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Ludwig]]></surname>
<given-names><![CDATA[WD]]></given-names>
</name>
<name>
<surname><![CDATA[Matutes]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Orfao]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Leukemia]]></source>
<year>1995</year>
<volume>10</volume>
<page-range>1783-6</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Impact of immunophenotyping on management of acute leukemias]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Béné]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Bernier]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Castoldi]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Faure]]></surname>
<given-names><![CDATA[GC]]></given-names>
</name>
<name>
<surname><![CDATA[Knapp]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Ludwig]]></surname>
<given-names><![CDATA[WD]]></given-names>
</name>
</person-group>
<source><![CDATA[Haematologica]]></source>
<year>1999</year>
<volume>84</volume>
<page-range>1024-34</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abdul-Hamid]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Classification of acute leukemia&#8212;the scientist&#8217;s perspective and challenge]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Antica]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[InTech]]></source>
<year>2011</year>
</nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fritz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Percy]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Jack]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Shanmugaratnam]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Sobin]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Parkin]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
</person-group>
<source><![CDATA[International Classification of Diseases for Oncology. World Health Organization First Revision]]></source>
<year>2013</year>
<publisher-loc><![CDATA[Geneve ]]></publisher-loc>
<publisher-name><![CDATA[WHO Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Childhood acute leukemias are frequent in Mexico City: descriptive epidemiology]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez-Saldivar]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Fajardo-Gutiérrez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bernáldez-Ríos]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez-Avalos]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Medina-Sanson]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Espinosa-Hernández]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[BMC Cancer]]></source>
<year>2011</year>
<volume>11</volume>
<page-range>355</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[El niño de población abierta con cáncer en México. Consideraciones epidemiológicas]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rivera-Luna]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Cárdenas-Cardos]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Olaya-Vargas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Shalkow-Klincovstein]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez-García]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez-González]]></surname>
<given-names><![CDATA[OA]]></given-names>
</name>
</person-group>
<source><![CDATA[An Med (Mex)]]></source>
<year>2015</year>
<volume>60</volume>
<page-range>91-7</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Mixed lineage leukemia rearranged childhood pro-B and CD10-negative pre-B acute lymphoblastic leukemia constitute a distinct clinical entity]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Attarbaschi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mann]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Konig]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Steiner]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Strehl]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Schreiberhuber]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Clin Cancer Res]]></source>
<year>2006</year>
<volume>12</volume>
<page-range>2988-94</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Acute leukemia in early childhood]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Emerenciano]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Koifman]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Pombo-de-Oliveira]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
</person-group>
<source><![CDATA[Braz J Med Biol Res]]></source>
<year>2007</year>
<volume>40</volume>
<page-range>749-60</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Molecular genetics of B-precursor acute lymphoblastic leukemia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mullighan]]></surname>
<given-names><![CDATA[CG]]></given-names>
</name>
</person-group>
<source><![CDATA[J Clin Invest]]></source>
<year>2012</year>
<volume>122</volume>
<page-range>3407-15</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Prevalence of gene rearrangements in Mexican children with acute lymphoblastic leukemia: a population study&#8212;Report from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bekker-Méndez]]></surname>
<given-names><![CDATA[VC]]></given-names>
</name>
<name>
<surname><![CDATA[Miranda-Peralta]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Núñez-Enríquez]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Olarte-Carrillo]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Guerra-Castillo]]></surname>
<given-names><![CDATA[FX]]></given-names>
</name>
<name>
<surname><![CDATA[Pompa-Mera]]></surname>
<given-names><![CDATA[EN]]></given-names>
</name>
</person-group>
<source><![CDATA[BioMed Res Int]]></source>
<year>2014</year>
</nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Daigle]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
<name>
<surname><![CDATA[Olhava]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<name>
<surname><![CDATA[Therkelsen]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Majer]]></surname>
<given-names><![CDATA[CR]]></given-names>
</name>
<name>
<surname><![CDATA[Sneeringer]]></surname>
<given-names><![CDATA[CJ]]></given-names>
</name>
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Cancer Cell]]></source>
<year>2011</year>
<volume>20</volume>
<page-range>53-65</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[t(1;19)(q23;p13) TCF3/PBX1]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alonso]]></surname>
<given-names><![CDATA[CN]]></given-names>
</name>
</person-group>
<source><![CDATA[Atlas Genet Cytogenet Oncol Haematol]]></source>
<year>2013</year>
<volume>17</volume>
<page-range>45-7</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Results of therapy for acute lymphoblastic leukemia in black and white children]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pui]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Sandlund]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
<name>
<surname><![CDATA[Pei]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Rivera]]></surname>
<given-names><![CDATA[GK]]></given-names>
</name>
<name>
<surname><![CDATA[Howard]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
</person-group>
<source><![CDATA[JAMA]]></source>
<year>2003</year>
<volume>290</volume>
<page-range>2001-7</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children&#8217;s Cancer Group]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Uckun]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
<name>
<surname><![CDATA[Sensel]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
<name>
<surname><![CDATA[Sather]]></surname>
<given-names><![CDATA[HN]]></given-names>
</name>
<name>
<surname><![CDATA[Gaynon]]></surname>
<given-names><![CDATA[PS]]></given-names>
</name>
<name>
<surname><![CDATA[Arthur]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
<name>
<surname><![CDATA[Lange]]></surname>
<given-names><![CDATA[BJ]]></given-names>
</name>
</person-group>
<source><![CDATA[J Clin Oncol]]></source>
<year>1998</year>
<volume>16</volume>
<page-range>527-35</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[t(12;21)(p12;q22)]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huret]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Bernheim]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Atlas Genet Cytogenet Oncol Haematol]]></source>
<year>1997</year>
<volume>1</volume>
<page-range>19-20</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shurtleff]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Buijs]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Behm]]></surname>
<given-names><![CDATA[FG]]></given-names>
</name>
<name>
<surname><![CDATA[Rubnitz]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Raimondi]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
<name>
<surname><![CDATA[Hancock]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
</person-group>
<source><![CDATA[Leukemia]]></source>
<year>1995</year>
<volume>9</volume>
<page-range>1985-9</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children&#8217;s Cancer Group (CCG)]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schultz]]></surname>
<given-names><![CDATA[KR]]></given-names>
</name>
<name>
<surname><![CDATA[Pullen]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Sather]]></surname>
<given-names><![CDATA[HN]]></given-names>
</name>
<name>
<surname><![CDATA[Shuster]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Devidas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Borowitz]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Blood]]></source>
<year>2007</year>
<volume>109</volume>
<page-range>926-35</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A new partner gene fused to ABL1 in a t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Braekeleer]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Douet-Guilbert]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Le Bris]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Berthou]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Morel]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[De Braekeleer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Leukemia]]></source>
<year>2007</year>
<volume>21</volume>
<page-range>2220-1</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Leucemia linfoblástica aguda en niños]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Verduzco-Aguirre]]></surname>
<given-names><![CDATA[HC]]></given-names>
</name>
<name>
<surname><![CDATA[Verduzco-Rodríguez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[López-Ariz]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Hematol]]></source>
<year>2012</year>
<volume>13</volume>
<page-range>172-6</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cytogenetics in acute lymphoblastic leukemia in Mexican children: an institutional experience]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez-Vera]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Mújica-Sánchez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Carnevale]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rivera-Luna]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Paredes]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Arch Med Res]]></source>
<year>2001</year>
<volume>32</volume>
<page-range>202-7</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cytogenetics and molecular genetics of acute lymphoblastic leukemia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mrózek]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Harper]]></surname>
<given-names><![CDATA[DP]]></given-names>
</name>
<name>
<surname><![CDATA[Aplan]]></surname>
<given-names><![CDATA[PD]]></given-names>
</name>
</person-group>
<source><![CDATA[Hematol Oncol Clin North Am]]></source>
<year>2009</year>
<volume>23</volume>
<page-range>991-1010</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Chemoimmunotherapy as a new standard of care for Burkitt leukaemia/lymphoma]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jabbour]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Kantarjian]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet]]></source>
<year>2016</year>
<volume>387</volume>
<page-range>2360-1</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Incidence of childhood cancer among Mexican children registered under a public medical insurance program]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rivera-Luna]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Correa-González]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Altamirano-Alvarez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez-Zubieta]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Cárdenas-Cardós]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Escamilla-Asian]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Cancer]]></source>
<year>2013</year>
<volume>132</volume>
<page-range>1646-50</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Childhood leukemia incidence in California: high and rising in the Hispanic population]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Giddings]]></surname>
<given-names><![CDATA[BM]]></given-names>
</name>
<name>
<surname><![CDATA[Whitehead]]></surname>
<given-names><![CDATA[TP]]></given-names>
</name>
<name>
<surname><![CDATA[Metayer]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
</person-group>
<source><![CDATA[Cancer]]></source>
<year>2016</year>
<volume>122</volume>
<page-range>2867-75</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Karyotypic analysis predicts outcome of pre-remission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Slovak]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Kopecky]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Cassileth]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
<name>
<surname><![CDATA[Harrington]]></surname>
<given-names><![CDATA[DH]]></given-names>
</name>
<name>
<surname><![CDATA[Theil]]></surname>
<given-names><![CDATA[KS]]></given-names>
</name>
<name>
<surname><![CDATA[Mohamed]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Blood]]></source>
<year>2000</year>
<volume>96</volume>
<page-range>4075-83</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Pediatric AML: from biology to cinical management]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[de Rooij]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Zwaan]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[van den Heuvel-Eibrink]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[J Clin Med]]></source>
<year>2015</year>
<volume>4</volume>
<page-range>127-49</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Mixed phenotype acute leukemia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Weinberg]]></surname>
<given-names><![CDATA[OK]]></given-names>
</name>
<name>
<surname><![CDATA[Seetharam]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ren]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Alizadeh]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Arber]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Clin Pathol]]></source>
<year>2014</year>
<volume>142</volume>
<page-range>803-8</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wei]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Zou]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[An]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Wan]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[BMC Pediatr]]></source>
<year>2015</year>
<volume>15</volume>
<page-range>80</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Genomic profiling of B-progenitor acute lymphoblastic leukemia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mullighan]]></surname>
<given-names><![CDATA[CG]]></given-names>
</name>
</person-group>
<source><![CDATA[Best Pract Res Clin Haematol]]></source>
<year>2011</year>
<volume>24</volume>
<page-range>489-503</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Individualized therapy for childhood acute lymphoblastic leukemia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Raetz]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Bhojwani]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Min]]></surname>
<given-names><![CDATA[D-J]]></given-names>
</name>
<name>
<surname><![CDATA[Carroll]]></surname>
<given-names><![CDATA[WL]]></given-names>
</name>
</person-group>
<source><![CDATA[Personalized Med]]></source>
<year>2005</year>
<volume>2</volume>
<page-range>349-61</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
