<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-888X</journal-id>
<journal-title><![CDATA[TIP. Revista especializada en ciencias químico-biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[TIP]]></abbrev-journal-title>
<issn>1405-888X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Zaragoza]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-888X2021000100206</article-id>
<article-id pub-id-type="doi">10.22201/fesz.23958723e.2021.329</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[El receptor S1P1 de la esfingosina1-fosfato: avances en el conocimiento de su estructura, función e importancia biomédica]]></article-title>
<article-title xml:lang="en"><![CDATA[The S1P1 receptor for sphingosine 1-phosphate: advances in the understanding of it&#8217;s structure, function and biological importance]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Morales]]></surname>
<given-names><![CDATA[Juan Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Sáinz]]></surname>
<given-names><![CDATA[J. Adolfo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero-Ávila]]></surname>
<given-names><![CDATA[M. Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Instituto de Fisiología Celular Depto. de Biología Celular y Desarrollo]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>24</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-888X2021000100206&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-888X2021000100206&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-888X2021000100206&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La esfingosina1-fosfato (S1P) es un metabolito intermediario en el catabolismo de la esfingomielina y un &#8220;lípido bioactivo&#8221;, con la capacidad de funcionar como hormona local al modular las funciones de distintas células y tejidos; en las células regula una gran variedad de respuestas, como la migración, la diferenciación y la sobrevivencia y en los tejidos la angiogénesis, la cardiogénesis, el desarrollo de las extremidades, la formación del sistema linfático y nervioso, entre otros procesos. El receptor S1P1 es un miembro de la familia de receptores acoplados a proteínas G que media muchas de las acciones de la S1P. Este receptor tiene una gran importancia médica por estar involucrado en la patogenia de la esclerosis múltiple. En condiciones fisiológicas el receptor S1P1 se expresa en la superficie de los linfocitos y regula la salida de esas células de los ganglios linfáticos por quimiotaxis. Por otra parte, la esclerosis múltiple es una enfermedad crónica, autoinmune y neurodegenerativa del sistema nervioso central, asociada en muchos casos con una progresión irreversible que conduce a la discapacidad. En la patogenia de esta enfermedad, después de que los linfocitos salen de los ganglios linfáticos, se encuentran en el torrente sanguíneo y atraviesan la barrera hematoencefálica invaden el sistema nervioso central, favorecen la secreción de citocinas inflamatorias que activan a los macrófagos y a otras células, destruyendo las vainas de mielina; además, los linfocitos B producen anticuerpos contra los componentes de la mielina incrementando la desmielinización, el daño axonal y neuronal que caracterizan a los pacientes con esclerosis múltiple.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The sphingolipid, sphingosine 1-phosphate (S1P), induces a plethora of actions at levels of individual cells and tissues modulating cell proliferation and promoting survival; at the tissue level, S1P promotes angiogenesis, cardiogenesis, limb development, the formation of the lymphatic and nervous systems, among other functions. The S1P1 receptor is a seven transmembrane-spanning domain protein that mediates many of the actions of S1P. The S1P1 receptor is of great medical importance because it is involved in the pathophysiology of multiple sclerosis. Under physiological conditions, S1P1 is expressed on the lymphocyte&#8217;s surface and is essential in regulating egression from lymph nodes in response to the concentration gradients of this lipid among tissues. On the other hand, multiple sclerosis, a chronic, autoimmune, and neurodegenerative disease of the central nervous system, is associated, in many cases, with an irreversible progression and disability. In the pathogenesis of multiple sclerosis, after the lymphocytes leave the lymph nodes, they are found in the bloodstream, cross the blood-brain barrier and invade the central nervous system, favoring the secretion of inflammatory cytokines that activate macrophages, and other cells, destroying the myelin sheaths; besides, B lymphocytes produce antibodies against myelin components, leading to demyelination, and the axonal and neuronal damage that characterizes multiple sclerosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[lípido]]></kwd>
<kwd lng="es"><![CDATA[S1P1]]></kwd>
<kwd lng="es"><![CDATA[esclerosis múltiple]]></kwd>
<kwd lng="es"><![CDATA[FTY720-P]]></kwd>
<kwd lng="es"><![CDATA[sistema nervioso]]></kwd>
<kwd lng="en"><![CDATA[lipid]]></kwd>
<kwd lng="en"><![CDATA[S1P1]]></kwd>
<kwd lng="en"><![CDATA[multiple sclerosis]]></kwd>
<kwd lng="en"><![CDATA[FTY720-P]]></kwd>
<kwd lng="en"><![CDATA[nervous system]]></kwd>
</kwd-group>
</article-meta>
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